2009-2017年宜宾市新发现HIV/AIDS病例首次CD4+T淋巴细胞检测及分析
|
摘要
目的通过对2009-2017年宜宾市可追踪到的新报告HIV/AIDS病例进行首次CD4+T淋巴细胞检测,了解并评估其免疫水平及疾病进展情况,为宜宾市艾滋病防治工作提供科学依据。方法使用单平台流式细胞仪对5 916例HIV/AIDS病例进行首次CD4+T淋巴细胞检测,所得资料采用SPSS 17.0进行单、多因素和χ~2分析。结果 2009-2017年宜宾市可追踪到的新发现HIV/AIDS病例首次CD4+T淋巴细胞检测中位数为248个/μl,不同性别(F=27.769,P<0.01)、不同年龄组间(F=90.095,P<0.01)CD4+T淋巴细胞计数差异有统计学意义。38.91%的病例首次CD4+T淋巴细胞≤200个/μl。结论 2009-2017年宜宾市可追踪到的新发现HIV/AIDS病例中超过1/3已进入艾滋病期,应加强宣传干预,扩大检测覆盖面,尽早发现、尽早治疗,加强随访,提高患者生活质量并减少传播。
Objective Through the first CD4 + T lymphocyte test in newly detected HIV/AIDS cases in Yibin from 2009 to 2017,to understand and assess their immunity levels and disease progression and provide a scientific basis for prevention and treatment of AIDS. Methods The first CD4 + T lymphocyte test was conducted among 5 916 HIV/AIDS cases using single-platform flow cytometers,and univariate,multi-variate and χ~2 analyses of the data were performed using SPSS 17.0 software.Results The median number of CD4 + T lymphocytes in the first test among newly detected HIV/AIDS cases in Yibin City during 2009 to 2017 was 248 cells/μc. There were significant differences in number of CD4+T lymphocytes between different genders(F=27.769,P<0.01) and age groups(F=90.095,P<0.01). The number of CD4+T lymphocytes in the first test was≤200 cells/μl in38.91% of the cases. Conclusion More than 1/3 of the newly detected HIV/AIDS cases in Yibin City in 2009 to 2017 have entered the AIDS period. Propaganda and intervention should be enhanced and the coverage of testing should be expanded for early discovery and early treatment; follow-up should be enhanced to improve patients' quality of life and reduce transmission.
Objective Through the first CD4 + T lymphocyte test in newly detected HIV/AIDS cases in Yibin from 2009 to 2017,to understand and assess their immunity levels and disease progression and provide a scientific basis for prevention and treatment of AIDS. Methods The first CD4 + T lymphocyte test was conducted among 5 916 HIV/AIDS cases using single-platform flow cytometers,and univariate,multi-variate and χ~2 analyses of the data were performed using SPSS 17.0 software.Results The median number of CD4 + T lymphocytes in the first test among newly detected HIV/AIDS cases in Yibin City during 2009 to 2017 was 248 cells/μc. There were significant differences in number of CD4+T lymphocytes between different genders(F=27.769,P<0.01) and age groups(F=90.095,P<0.01). The number of CD4+T lymphocytes in the first test was≤200 cells/μl in38.91% of the cases. Conclusion More than 1/3 of the newly detected HIV/AIDS cases in Yibin City in 2009 to 2017 have entered the AIDS period. Propaganda and intervention should be enhanced and the coverage of testing should be expanded for early discovery and early treatment; follow-up should be enhanced to improve patients' quality of life and reduce transmission.
引文
[1]骆玉萍,陈晓能,刘思超.艾滋病相关支原体感染对患者免疫功能的影响[J].中国医学工程,2017,25(2):92-94.
[2]中华人民共和国为卫生部,联合国艾滋病规划署,世界卫生组织. 2011年中国艾滋病疫情估计[J].中国艾滋病性病,2012,18(1):1-5.
[3]马宁,康续,赵砚,等.辽宁省2013年新报告HIV/AIDS病人首次CD4+T细胞检测状况分析[J].中国艾滋病性病,2016,22(5):328-330.
[4]代娣,尚红,姜拥军,等.我国HIV/AIDS患者外周血CD4+T淋巴细胞凋亡与疾病进展的相关性分析[J].中国免疫学杂志,2006,22(12):1156-1157.
[5]Mellors JW,Munoz A,Giorgi JV,et al. Plasma viral load and CD4+T lymphocytes as prognostic markers of HIV-1 infection[J]. Annals of Internal Medicine,1997,126(12):946-954.
[6]汤后林,毛宇嵘,肖瑶,等. 2010年全国新发现HIV/AIDS病例首次CD4检测现状分析[J].中国艾滋病性病,2012,18(4):218-233.
[7]叶润华,段松,项丽芬,等.云南省德宏州无抗病毒治疗史的HIV感染者CD4+T淋巴细胞计数自然变化及其影响因素[J].中华流行病学杂志,2011,32(9):882-887.
[8]贾青,吴建英,马韶辉,等.青海省641例新发现HIV抗体阳性者首次CD4+T淋巴细胞检测结果分析[J].现代预防医学,2017,44(10):1871-1907.
[9]刘曦,李春娜,丁立,等. CD4细胞计数与HIV相关症状及机会性感染的相关性分析[J].中国艾滋病性病,2012,18(11):767-769.
[10]王爱霞,王福生,王清月,等.艾滋病诊疗指南[J].中国感染与化疗杂志,2006,6(4):265-278.
[11]董潇潇,许文炯,董晓庆,等.2014-2015年南京市新发现HIV/AIDS病例首次T淋巴细胞亚群的检测分析[J].中国医学创新,2016,13(32):28-61.
[12]李春雷.2004-2013年宜宾市HIV/AIDS病例流行特征分析[J].职业卫生与病伤,2015,30(5):275-277.
[13]黑发欣,王璐,秦倩倩,等.中国50岁以上人群艾滋病疫情特点及流行因素分析[J].中华流行病学杂志,2011,32(5):526-527.
[14]郑武,笪琴,汤恒,等.湖北省2003-2015年艾滋病抗病毒治疗死亡病例流行病学分析[J].中国热带医学,2017,17(10):1002-1026.
[2]中华人民共和国为卫生部,联合国艾滋病规划署,世界卫生组织. 2011年中国艾滋病疫情估计[J].中国艾滋病性病,2012,18(1):1-5.
[3]马宁,康续,赵砚,等.辽宁省2013年新报告HIV/AIDS病人首次CD4+T细胞检测状况分析[J].中国艾滋病性病,2016,22(5):328-330.
[4]代娣,尚红,姜拥军,等.我国HIV/AIDS患者外周血CD4+T淋巴细胞凋亡与疾病进展的相关性分析[J].中国免疫学杂志,2006,22(12):1156-1157.
[5]Mellors JW,Munoz A,Giorgi JV,et al. Plasma viral load and CD4+T lymphocytes as prognostic markers of HIV-1 infection[J]. Annals of Internal Medicine,1997,126(12):946-954.
[6]汤后林,毛宇嵘,肖瑶,等. 2010年全国新发现HIV/AIDS病例首次CD4检测现状分析[J].中国艾滋病性病,2012,18(4):218-233.
[7]叶润华,段松,项丽芬,等.云南省德宏州无抗病毒治疗史的HIV感染者CD4+T淋巴细胞计数自然变化及其影响因素[J].中华流行病学杂志,2011,32(9):882-887.
[8]贾青,吴建英,马韶辉,等.青海省641例新发现HIV抗体阳性者首次CD4+T淋巴细胞检测结果分析[J].现代预防医学,2017,44(10):1871-1907.
[9]刘曦,李春娜,丁立,等. CD4细胞计数与HIV相关症状及机会性感染的相关性分析[J].中国艾滋病性病,2012,18(11):767-769.
[10]王爱霞,王福生,王清月,等.艾滋病诊疗指南[J].中国感染与化疗杂志,2006,6(4):265-278.
[11]董潇潇,许文炯,董晓庆,等.2014-2015年南京市新发现HIV/AIDS病例首次T淋巴细胞亚群的检测分析[J].中国医学创新,2016,13(32):28-61.
[12]李春雷.2004-2013年宜宾市HIV/AIDS病例流行特征分析[J].职业卫生与病伤,2015,30(5):275-277.
[13]黑发欣,王璐,秦倩倩,等.中国50岁以上人群艾滋病疫情特点及流行因素分析[J].中华流行病学杂志,2011,32(5):526-527.
[14]郑武,笪琴,汤恒,等.湖北省2003-2015年艾滋病抗病毒治疗死亡病例流行病学分析[J].中国热带医学,2017,17(10):1002-1026.