中药及其复方抗皮肤光老化的机制及应用研究进展
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摘要
皮肤光老化是由于皮肤长期接受日光照射所引起的损害,属于外源性老化,是引起皮肤衰老的重要原因之一,主要的症状表现为皮肤干燥、粗糙、松弛、皱纹产生,局部出现色素沉着等。引起皮肤光老化的机制多种多样且极其复杂,主要涉及氧化应激、细胞凋亡、基质金属蛋白酶的作用、炎症反应等方面,而皮肤光老化的防治方法主要包括防晒剂、抗氧化剂和抗炎制剂的使用等。近年来,皮肤光老化的防治与改善已成为国际上的热点问题,因此,开发具有确切抗光老化作用的药物并阐明其抗光老化的作用机制是目前亟待解决的问题。临床上虽然维甲酸等药物可改善皮肤光老化,但长期大量使用会出现中枢神经系统的副作用,并且大部分药物对皮肤有较强刺激及损伤。中药具有取材天然,作用平稳,毒副作用小等优势,并且中药及其复方在中医美容应用历史悠久、疗效确切且具有独特的作用,本文意在探讨近年来中药抗皮肤光老化的机制以及现代应用研究进展,以期为探究皮肤光老化的机制与防治工作提供一些参考。
Skin photoaging is caused by long-term exposure to sunlight. It is a kind of exogenous aging and one of the important causes of skin aging. The main symptoms include dry skin,roughness,sagging,wrinkles and localized pigmentation. There are diverse and complex mechanisms for causing skin photoaging,mainly involving oxidative stress,apoptosis,the role of matrix metalloproteinases,inflammatory reactions. The prevention and treatment methods of skin photoaging mainly include sunscreens, antioxidants and anti-inflammatory preparations. In recent years,the prevention and improvement of skin photoaging have become hotspots in the world. Therefore, the development of drugs with a defined anti-photoaging effect and clear anti-photoaging mechanism is urgent. Clinically,although retinoic acid and other drugs can alleviate skin photoaging,long-term use can cause side effects on central nervous system,and most of them have a strong irritation and damage to the skin. Traditional Chinese medicine( TCM) has the advantages of natural material,stable action,less toxic and side effects; furthermore,TCM and its compound have a long history in curative application,with a unique effect.This paper explores the anti-skin photoaging mechanism of TCM in recent years,its modern application and study progress,in order to provide some reference for exploring the mechanism and prevention of skin photoaging.
Skin photoaging is caused by long-term exposure to sunlight. It is a kind of exogenous aging and one of the important causes of skin aging. The main symptoms include dry skin,roughness,sagging,wrinkles and localized pigmentation. There are diverse and complex mechanisms for causing skin photoaging,mainly involving oxidative stress,apoptosis,the role of matrix metalloproteinases,inflammatory reactions. The prevention and treatment methods of skin photoaging mainly include sunscreens, antioxidants and anti-inflammatory preparations. In recent years,the prevention and improvement of skin photoaging have become hotspots in the world. Therefore, the development of drugs with a defined anti-photoaging effect and clear anti-photoaging mechanism is urgent. Clinically,although retinoic acid and other drugs can alleviate skin photoaging,long-term use can cause side effects on central nervous system,and most of them have a strong irritation and damage to the skin. Traditional Chinese medicine( TCM) has the advantages of natural material,stable action,less toxic and side effects; furthermore,TCM and its compound have a long history in curative application,with a unique effect.This paper explores the anti-skin photoaging mechanism of TCM in recent years,its modern application and study progress,in order to provide some reference for exploring the mechanism and prevention of skin photoaging.
引文
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