摘要
目的:通过检测肿瘤出芽、淋巴结转移以及血管内皮生长因子-C(VEGF-C)表达水平,分析口腔癌中肿瘤出芽与VEGF-C表达及淋巴结转移的相关关系,为临床治疗提供理论参考。方法:选取2009年1月-2013年1月4年间在我院接受诊治且资料完整63例口腔癌患者作为研究对象,观察肿瘤出芽、VEGF-C表达和淋巴结转移情况,分析相互之间的相关关系。结果:本次纳入研究的患者中,检出肿瘤出芽患者40例,所占比例为63.5%,VEGF-C表达阳性患者39例,阳性率率为61.9%,淋巴结转移患者40例,转移率为63.5%;肿瘤出芽与淋巴结转移的符合率为84.1%,肿瘤出芽与VEGF-C的表达符合率为79.4%,VEGF-C的表达与淋巴结转移发生的符合率为76.2%。肿瘤出芽与淋巴结转移呈正相关,经Spear相关分析,r=0.932,P<0.05,与VEGF-C的表达也呈正相关,经Spear相关分析,r=0.897,P<0.05。结论:肿瘤出芽与VEGF-C的表达水平和淋巴结转移均呈正相关关系,可用于预测判断口腔癌淋巴结转移情况。
Objective: To analysis the relation of tumour budding,VEGF-C expression and lymph node metastasis by detection tumour budding,lymph node metastasis and vascular endothelial growth factor C(VEGF-C) expression level in oral carcinoma,and provide reference for clinical treatment.Methods: 63 cases of oral cancer patients who accept the diagnosis and treatment in our hospital between 2009.1 and 2013.1,and all the data integrity as the research object,to observe the tumor budding,VEGF-C expression and lymph node metastasis,and analysis of the relationship between each other.Results: The patients included in the study,the positive ratio of tumor budding,VEGF-C expression and lymph node metastasis was 40(63.5%),39(61.9%) and 40(63.5%).The accuracy of tumor budding and lymph node metastasis was 84.1%,The accuracy of tumor budding and the expression of VEGF-C coincidence rate was 79.4%,The accuracy of the expression of VEGF-C with lymph node metastasis coincidence rate was 76.2%.Budding of tumor and lymph node metastasis were positively correlated,r = 0.932,and the expression of VEGF-C were positively correlated,r = 0.897.Tumour budding was positively correlated with lymph node metastasis or VEGF-C expression,r=0.932,P<0.05 or r=0.897,P<0.05.Conclusion: Tumour budding was positively correlated with lymph node metastasis and VEGF-C expression,and can be used to predict lymph node metastasis in oral carcinoma.
引文
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