绝经后女性铁蓄积与骨代谢及机体炎症反应的相关性研究
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摘要
目的研究绝经后女性铁蓄积与骨代谢及机体炎症反应的相关性。方法将117名绝经后女性体检者按照骨密度(bone mineral density,BMD)值分成3组:骨量正常组(T≥-1)、骨量减少组(-2.5 Objective To study the correlation between iron excess and bone metabolism and inflammatory response in postmenopausal women. Methods A total of117 postmenopausal women were divided into normal(T≥-1), bone loss(BL)(-2.5
引文
[1] Rishi G,Secondes ES,Wallace DF,et al.Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2 [J].American Journal of Physiology,Gastrointestinal and Liver Physiology,2016,310(3):G171-G180.
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[3] Katsumata SI,Katsumata-Tsuboi R,Uehara M,et al.Severe iron deficiency decreases both bone formation and bone resorption in rats [J].Journal of Nutrition,2009,139(2):238-243.
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[7] Xiao W,Beibei F,Guangsi S,et al.Iron overload increases osteoclastogenesis and aggravates the effects of ovariectomy on bone mass [J].Journal of Endocrinology,2015,226(3):121-134.
[8] Chen B,Yan YL,Liu C,et al.Therapeutic effect of deferox-amine on iron overload-induced inhibition of osteogenesis in a zebrafish model [J].Calcified Tissue International,2014,94(3):353-360.
[9] Tella SH,Gallagher JC.Prevention and treatment of postmenopausal osteoporosis [J].Journal of Steroid Biochemistry and Molecular Biology,2014(142):155-170.
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[12] Wynnyckyj C,Omelon S,Savage K,et al.Grynpas,a new tool to assess the mechanical properties of bone due to collagen degradation [J].Bone,2009,44(5):840-848.
[13] Muiznieks LD,Keeley FW.Molecular assembly and mechanical properties of the extracellular matrix:a fibrous protein perspective [J].Biochimica et Biophysica Acta—Molecular Basis of Disease,2013,1832(7):866-875.
[14] Leeming DJ,Bay-Jensen AC,Vassiliadis E,et al.Post-translational modifications of the extracellular matrix are key events in cancer progression:opportunities for biochemical marker development [J].Biomarkers,2011,16(3):193-205.
[15] Dragsb?k K,Neergaard JS,Hansen HB,et al.Matrix metalloproteinase mediated type I collagen degradation—An independent risk factor for mortality in women [J].EBioMedicine,2015,2(7):723-729.
[16] Liu Y,Ke XY,Tian L,et al.Relationship between Bone Markers and the progression of multiple myeloma [J].Zhongguo ShiYanXueYeXue ZaZhi,2016,24(5):1433-1436.
[17] 欧阳辉,何雪常,沈龙彬,等.运动对类风湿关节炎伴骨质疏松患者的骨密度及骨代谢的影响[J].中国骨质疏松杂志,2018,24(2):174-180.
[18] Koivula MK,Risteli L,Risteli J.Measurement of aminoterminal propeptide of type I procollagen (PINP) in serum [J].Clinical Biochemistry,2012,45(12):920-927.
[19] Herrmann M,Seibel M.The amino- and carboxyterminal cross-linked telopeptides of collagen type I,NTX-I and CTX-I:a comparative review [J].Clinica Chimica Acta,2008,393(2):57-75.
[20] Jung K,Lein M.Bone turnover markers in serum and urine as diagnostic,prognostic and monitoring biomarkers of bone metastasis [J].Biochimica et Biophysica Acta—Reviews on Cancer,2014,1846(2):425-438.
[21] Osorio R,Yamauti M,Osorio E,et al.Zinc reduces collagen degradation in demineralized human dentin explants [J].Journal of Dentistry,2011,39(2):148-153.
[22] LaFleur J,McAdam-Marx C,Kirkness C,et al.Clinical risk factors for fracture in postmenopausal osteo-porotic women:a review of the recent literature [J].Annals of Pharmacotherapy,2008,42(3):375-386.
[23] Stamm TA,Pieber K,Crevenna R,et al.Impairment in the activities of daily living in older adults with and without osteoporosis,osteoarthritis and chronic back pain:a secondary analysis of population-based health survey data [J].BMC Musculoskeletal Disorders,2016,17(1):139.
[24] Qi H,Bao J,An G,et al.Association between the metabolome and bone mineral density in pre- and post-menopausal Chinese women using GC-MS [J].Molecular Biosystems,2016,12(7):2265-2275.
[25] Wan X,Zhao Y,Burge R,et al.Actions of osteoporosis treatments on bone histomorphometric remodeling:a two-fold principal component analysis [J].Osteoporosis International,2013,24(12):3011-3019.
[26] Lahdenper¨a M,Mar KU,Lummaa V.Reproductive cessation and post-reproductive lifespan in Asian elephants and pre-industrial humans [J].Frontiers in Zoology,2014,11(1):54.
[27] Maciejewska K,Drzazga Z,Kaszuba M.Role of trace elements (Zn,Sr,Fe) in bone development:energy dispersive X-ray fluorescence study of rat bone and tooth tissue [J].Bio Factors,2014,40(4):425-435.
[28] Balogh E,Tolnai E,Nagy B,et al.Iron overload inhibits osteogenic commitment and differentiation of mesenchymal stem cells via the induction of ferritin [J].Biochimica et Biophysica Acta—Molecular Basis of Disease,2016,1862(9):1640-1649.
[29] Okabe H,Suzuki T,Uehara E,et al.The bone marrow hematopoietic microenvironment is impaired in iron-overloaded mice [J].European Journal of Haematology,2014,93(2):118-128.
[30] Thanakun S,Pornprasertsuk-Damrongsri S,Izumi Y.C-reactive protein levels and the association of carotid artery calcification with tooth loss [J].Oral Diseases,2017,23(1):69-77.
[31] 刘文华,汤珊珊,黄哲人,等.绝经后女性同型半胱氨酸、脂质水平、CRP、NLR与骨质减少的关系[J].国际妇产科学杂志,2016,43(1):103-106.
[2] Bourre JM.Effects of nutrients (in food) on the structure and function of the nervous system:update on dietary requirements for brain [J].The Journal of Nutrition,Health and Aging,2006,10(5):377-385.
[3] Katsumata SI,Katsumata-Tsuboi R,Uehara M,et al.Severe iron deficiency decreases both bone formation and bone resorption in rats [J].Journal of Nutrition,2009,139(2):238-243.
[4] Amelio PD,Cristofaro MA,Tamone C,et al.Role of iron metabolism and oxidative damage in postmenopausal bone loss[J].Bone,2008,43(6):1010-1015.
[5] Messer JG,Kilbarger AK,Erikson KM,et al.Iron overload alters iron-regulatory genes and proteins,down-regulates osteoblastic phenotype,and is associated with apoptosis in fetal rat calvaria cultures [J].Bone,2009,45(5):972-979.
[6] Yamasaki K,Hagiwara H.Excess iron inhibits osteoblast metabolism [J].Oxicology Letters,2009,191(2-3):211-215.
[7] Xiao W,Beibei F,Guangsi S,et al.Iron overload increases osteoclastogenesis and aggravates the effects of ovariectomy on bone mass [J].Journal of Endocrinology,2015,226(3):121-134.
[8] Chen B,Yan YL,Liu C,et al.Therapeutic effect of deferox-amine on iron overload-induced inhibition of osteogenesis in a zebrafish model [J].Calcified Tissue International,2014,94(3):353-360.
[9] Tella SH,Gallagher JC.Prevention and treatment of postmenopausal osteoporosis [J].Journal of Steroid Biochemistry and Molecular Biology,2014(142):155-170.
[10] Chen B,Li GF,Shen Y,et al.Reducing iron accumulation:a potential approach for the prevention and treatment of postmenopausal osteoporosis [J].Experimental and Therapeutic Medicine,2015,10(1):7-11.
[11] Ferreira AM,Gentile P,Chiono V,et al.Collagen for bone tissue regeneration [J].Acta Biomaterialia,2012,8(9):3191-3200.
[12] Wynnyckyj C,Omelon S,Savage K,et al.Grynpas,a new tool to assess the mechanical properties of bone due to collagen degradation [J].Bone,2009,44(5):840-848.
[13] Muiznieks LD,Keeley FW.Molecular assembly and mechanical properties of the extracellular matrix:a fibrous protein perspective [J].Biochimica et Biophysica Acta—Molecular Basis of Disease,2013,1832(7):866-875.
[14] Leeming DJ,Bay-Jensen AC,Vassiliadis E,et al.Post-translational modifications of the extracellular matrix are key events in cancer progression:opportunities for biochemical marker development [J].Biomarkers,2011,16(3):193-205.
[15] Dragsb?k K,Neergaard JS,Hansen HB,et al.Matrix metalloproteinase mediated type I collagen degradation—An independent risk factor for mortality in women [J].EBioMedicine,2015,2(7):723-729.
[16] Liu Y,Ke XY,Tian L,et al.Relationship between Bone Markers and the progression of multiple myeloma [J].Zhongguo ShiYanXueYeXue ZaZhi,2016,24(5):1433-1436.
[17] 欧阳辉,何雪常,沈龙彬,等.运动对类风湿关节炎伴骨质疏松患者的骨密度及骨代谢的影响[J].中国骨质疏松杂志,2018,24(2):174-180.
[18] Koivula MK,Risteli L,Risteli J.Measurement of aminoterminal propeptide of type I procollagen (PINP) in serum [J].Clinical Biochemistry,2012,45(12):920-927.
[19] Herrmann M,Seibel M.The amino- and carboxyterminal cross-linked telopeptides of collagen type I,NTX-I and CTX-I:a comparative review [J].Clinica Chimica Acta,2008,393(2):57-75.
[20] Jung K,Lein M.Bone turnover markers in serum and urine as diagnostic,prognostic and monitoring biomarkers of bone metastasis [J].Biochimica et Biophysica Acta—Reviews on Cancer,2014,1846(2):425-438.
[21] Osorio R,Yamauti M,Osorio E,et al.Zinc reduces collagen degradation in demineralized human dentin explants [J].Journal of Dentistry,2011,39(2):148-153.
[22] LaFleur J,McAdam-Marx C,Kirkness C,et al.Clinical risk factors for fracture in postmenopausal osteo-porotic women:a review of the recent literature [J].Annals of Pharmacotherapy,2008,42(3):375-386.
[23] Stamm TA,Pieber K,Crevenna R,et al.Impairment in the activities of daily living in older adults with and without osteoporosis,osteoarthritis and chronic back pain:a secondary analysis of population-based health survey data [J].BMC Musculoskeletal Disorders,2016,17(1):139.
[24] Qi H,Bao J,An G,et al.Association between the metabolome and bone mineral density in pre- and post-menopausal Chinese women using GC-MS [J].Molecular Biosystems,2016,12(7):2265-2275.
[25] Wan X,Zhao Y,Burge R,et al.Actions of osteoporosis treatments on bone histomorphometric remodeling:a two-fold principal component analysis [J].Osteoporosis International,2013,24(12):3011-3019.
[26] Lahdenper¨a M,Mar KU,Lummaa V.Reproductive cessation and post-reproductive lifespan in Asian elephants and pre-industrial humans [J].Frontiers in Zoology,2014,11(1):54.
[27] Maciejewska K,Drzazga Z,Kaszuba M.Role of trace elements (Zn,Sr,Fe) in bone development:energy dispersive X-ray fluorescence study of rat bone and tooth tissue [J].Bio Factors,2014,40(4):425-435.
[28] Balogh E,Tolnai E,Nagy B,et al.Iron overload inhibits osteogenic commitment and differentiation of mesenchymal stem cells via the induction of ferritin [J].Biochimica et Biophysica Acta—Molecular Basis of Disease,2016,1862(9):1640-1649.
[29] Okabe H,Suzuki T,Uehara E,et al.The bone marrow hematopoietic microenvironment is impaired in iron-overloaded mice [J].European Journal of Haematology,2014,93(2):118-128.
[30] Thanakun S,Pornprasertsuk-Damrongsri S,Izumi Y.C-reactive protein levels and the association of carotid artery calcification with tooth loss [J].Oral Diseases,2017,23(1):69-77.
[31] 刘文华,汤珊珊,黄哲人,等.绝经后女性同型半胱氨酸、脂质水平、CRP、NLR与骨质减少的关系[J].国际妇产科学杂志,2016,43(1):103-106.