玻璃体液化与玻璃体超微空间结构改变的研究进展
摘要
<正>玻璃体是一种少细胞而富含水分的细胞外基质(含水为98%)[1],呈透明的凝胶状态,主要由纤细的胶原结构和亲水的透明质酸和很少的玻璃体细胞组成玻璃体凝胶。除了在眼球发育中发挥重要的作用外,还能对视网膜和晶状体起到减震、支持作用,并能阻止大分子物质和细胞进入玻璃体,而维持其透明。玻璃体有其特殊的超微结构,该超微结构变化与年龄的增长明显相关,最终导致玻璃体液化[2]。本文就玻璃体液化与玻璃体超微空间结构改变的研究进展作一综述。
引文
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[13]Goldenberg D T,Giblin F J,Cheng M,et al.Posterior vitreous detachment with microplasmin alters the retinal penetration of intravitreal bevacizumab(Avastin)in ra-bbit eyes[J].Retina,2011,31(2):393-400.
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[15]Al Kahtani E,Alkatan H M.Surgical treatment and hist-opathology of a symptomatic free-floating primary pig-ment epithelial iris cyst in the anterior vitreous[J].Middle East Afr J Ophthalmol,2011,18(4):331-332.
[16]Jin H X,Song W Y,Xin Z M,et al.Effects of cumulus cells on vitreous cryopreservation of human matureoocytes and clinical pregnancy outcomes[J].Reprod Sci,2012,19(2):216-220.
[17]Fernández Mdel P,Villegas V M,Armando L O.Vitr-eous cultures and antibiotic analysis in Puerto Rican endophthalmitis patients[J].P R Health Sci J,2011,30(4):198-202.
[18]Matsuo T,Ichimura K.Immunocytochemical diagnosis as inflammation by vitrectomy cell blocks in patients with vitreous opacity[J].Ophthalmology,2012,119(4):827-837.
[19]Rossi T,Querzoli G,Pasqualitto G,et al.Ultrasound ima-ging velocimetry of the human vitreous[J].Exp Eye Res,2012,99:98-104.
[20]Benitez Herreros J,Lopez Guajardo L,Camara Gonzalez C,et al.Effect of interposition maneuver during cannula removal on vitreous incarceration rate in vitrectomized eyes measured by ultrasound biomicroscopy[J].Curr Eye Res,2012,37(9):809-812.
[2]Hong S M,Yang Y S.A potential role of crystallin in the vitreous bodies of rats after ischemia-reperfusion injury[J].Korean J Ophthalmol,2012,26(4):248-254.
[3]Shields C L,Romanelli Gobbi M,Lally S E,et al.Vitreous asteroid hyalosis prolapse into the anterior chamber simulating iris metastasis[J].Middle East Afr J Ophthal-mol,2012,19(3):346-348.
[4]Rishi P,Mathur G,Rishi E.Fractured Ozurdex TM imp-lant in the vitreous cavity[J].Indian J Ophthalmol,2012,60(4):337-338.
[5]Hwang Y H,Kim Y Y.Effect of peripapillary vitreous op-acity on retinal nerve fiber layer thickness measurem-ent using optical coherence tomography[J].Arch Ophthal-mol,2012,130(6):789-792.
[6]Labat Robert J,Pouliquen Y,Robert L.Eye connective ti-ssues:cornea and vitreous body[J].Biol Aujourdhui,2012,206(2):145-160.
[7]Wang H,Feng L,Hu J W,et al.Characterisation of the vitreous proteome in proliferative diabetic retinopathy[J].Proteome Sci,2012,10(1):15.
[8]Walia S,Clermont A C,Gao B B,et al.Vitreous proteo-mics and diabetic retinopathy[J].Semin Ophthalmol,2010,25(5/6):289-294.
[9]Sanches L R,Seulin S C,Leyton V,et al.Determination of opiates in whole blood and vitreous humor:a study of the matrix effect and an experimental design to optimize con-ditions for the enzymatic hydrolysis of glucuronides[J].J Anal Toxicol,2012,36(3):162-170.
[10]Abrishami M,Moosavi M N,Shoeibi N,et al.Intravitreal tissue plasminogen activator to treat refractory diabetic macular edema by induction of posterior vitreous detachment[J].Retina,2011,31(10):2065-2070.
[11]Schramm C,Spitzer M S,Henke Fahle S,et al.The cro-sslinked biopolymer hyaluronic acid as an artificial vitr-eous substitute[J].Invest Ophthalmol Vis Sci,2012,53(2):613-621.
[12]Gawecki M,Doroszkiewicz M,Rydzewski J.Age related macular degeneration and presence of posterior vitreous detachment[J].Klin Oczna,2010,112(7/9):210-212.
[13]Goldenberg D T,Giblin F J,Cheng M,et al.Posterior vitreous detachment with microplasmin alters the retinal penetration of intravitreal bevacizumab(Avastin)in ra-bbit eyes[J].Retina,2011,31(2):393-400.
[14]Noma H,Funatsu H,Mimura T,et al.Vitreous inflam-matory factors and serous retinal detachment in central retinal vein occlusion:a case control series[J].J Infla-mm(Lond),2011,8:38.
[15]Al Kahtani E,Alkatan H M.Surgical treatment and hist-opathology of a symptomatic free-floating primary pig-ment epithelial iris cyst in the anterior vitreous[J].Middle East Afr J Ophthalmol,2011,18(4):331-332.
[16]Jin H X,Song W Y,Xin Z M,et al.Effects of cumulus cells on vitreous cryopreservation of human matureoocytes and clinical pregnancy outcomes[J].Reprod Sci,2012,19(2):216-220.
[17]Fernández Mdel P,Villegas V M,Armando L O.Vitr-eous cultures and antibiotic analysis in Puerto Rican endophthalmitis patients[J].P R Health Sci J,2011,30(4):198-202.
[18]Matsuo T,Ichimura K.Immunocytochemical diagnosis as inflammation by vitrectomy cell blocks in patients with vitreous opacity[J].Ophthalmology,2012,119(4):827-837.
[19]Rossi T,Querzoli G,Pasqualitto G,et al.Ultrasound ima-ging velocimetry of the human vitreous[J].Exp Eye Res,2012,99:98-104.
[20]Benitez Herreros J,Lopez Guajardo L,Camara Gonzalez C,et al.Effect of interposition maneuver during cannula removal on vitreous incarceration rate in vitrectomized eyes measured by ultrasound biomicroscopy[J].Curr Eye Res,2012,37(9):809-812.