腰椎脂肪含量、R2~*与骨密度及年龄的相关性
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摘要
目的分析腰椎脂肪含量(FF)、R2~*与骨密度(BMD)及年龄的相关性,探讨腰椎FF与R2~*的诊断价值。资料与方法测定65例符合条件的研究对象L1、L2、L3、L4椎体的FF、R2~*,对各椎体间的FF及R2~*进行单因素分析。分析L1～L4椎体FF及R2~*分别与BMD及年龄的相关性及FF与R2~*的相关性。结果 L1、L2、L3、L4椎体的BMD、FF、R2~*比较,差异均无统计学意义(P>0.05)。L1～L4椎体平均BMD与FF呈负相关(r=-0.411,P=0.001),与R2~*呈正相关(r=0.395,P=0.001)。年龄与BMD呈负相关(r=-0.405,P=0.001),与FF呈正相关(r=0.578,P=0.000);而R2~*与年龄无相关性(r=-0.014,P=0.911)。L1～L4椎体平均FF与R2~*无相关性(r=-0.11,P=0.382)。结论定量分析腰椎FF及R2~*有助于评价骨强度,具有潜在的诊断骨质疏松的能力。
Purpose To analyze the correlation between the fat fraction(FF) and R2~* values(R2~*) in the lumbar and bone mineral density(BMD) and age, and to investigate the diagnostic value of lumbar FF and R2~*. Materials and Methods The FF and R2~* in L1,L2, L3 and L4 vertebral bodies of the 65 patients who met the study criteria were measured and univariate analysis was performed on FF and R2~* between the vertebral bodies. The FF and R2~* in L1-L4 vertebral bodies were respectively correlated with BMD and age. Then the correlation between FF and R2~* was analyzed. Results There was no significant difference in BMD, FF and R2~* between L1, L2,L3 and L4 vertebral bodies(P>0.05). The mean BMD was significantly negatively correlated with FF in L1-L4 vertebral bodies(r=-0.411, P=0.001) while the mean BMD was significantly positively correlated with R2~*(r=0.395, P=0.001). There was a significantly negative correlation between age and BMD(r=-0.405, P=0.001) while there was a significantly positive correlation between age and FF(r=0.578, P=0.000). The R2~* had no correlation with age(r=-0.014, P=0.911). The mean FF in L1-L4 vertebral bodies had no correlation with R2~*(r=-0.11, P=0.382). Conclusion Quantitative analysis of lumbar FF and R2~* helps to assess bone strength and has the potential to diagnose osteoporosis.
Purpose To analyze the correlation between the fat fraction(FF) and R2~* values(R2~*) in the lumbar and bone mineral density(BMD) and age, and to investigate the diagnostic value of lumbar FF and R2~*. Materials and Methods The FF and R2~* in L1,L2, L3 and L4 vertebral bodies of the 65 patients who met the study criteria were measured and univariate analysis was performed on FF and R2~* between the vertebral bodies. The FF and R2~* in L1-L4 vertebral bodies were respectively correlated with BMD and age. Then the correlation between FF and R2~* was analyzed. Results There was no significant difference in BMD, FF and R2~* between L1, L2,L3 and L4 vertebral bodies(P>0.05). The mean BMD was significantly negatively correlated with FF in L1-L4 vertebral bodies(r=-0.411, P=0.001) while the mean BMD was significantly positively correlated with R2~*(r=0.395, P=0.001). There was a significantly negative correlation between age and BMD(r=-0.405, P=0.001) while there was a significantly positive correlation between age and FF(r=0.578, P=0.000). The R2~* had no correlation with age(r=-0.014, P=0.911). The mean FF in L1-L4 vertebral bodies had no correlation with R2~*(r=-0.11, P=0.382). Conclusion Quantitative analysis of lumbar FF and R2~* helps to assess bone strength and has the potential to diagnose osteoporosis.
引文
[1]陈慧莹,袁慧书.磁共振脂肪定量技术在骨骼疾病中的应用与展望.磁共振成像,2014,5(2):150-155.
[2]Blake GM,Griffith JF,Yeung DK,et al.Effect of increasing vertebral marrow fat content on BMD measurement,T-score status and fracture risk prediction by DXA.Bone,2009,44(3):495-501.
[3]李轶雯,袁慧书.磁共振脂肪定量技术在骨质疏松症中的应用.中国医学影像学杂志,2017,51(1):52-55.
[4]Shen W,Scherzer R,Gantz M,et al.Relationship between MRI-measured bone marrow adipose tissue and hip and spine bone mineral density in African-American and Caucasian participants:the CARDIA study.J Clin Endocrinol Metab,2012,97(4):1337-1346.
[5]Kühn JP,Hernando D,Meffert PJ,et al.Proton-density fat fraction and simultaneous R2*stimation as an MRI tool for assessment of osteoporosis.Eur Radiol,2013,23(12):3432-3439.
[6]Argyropoulou MI,Astrakas L.MRI evaluation of tissue Iron burden in patients withβ-thalassaemia major.Pediatr Radiol,2007,37(37):1191-1200.
[7]代岳,王姗,徐慧婷,等.IDEAL-IQ技术对不同年龄椎体骨髓脂肪含量的定量评价.中国医学计算机成像杂志,2017,23(2):161-165.
[8]张伟,王兵,张林林,等.绝经后股骨颈骨折股骨头骨铁含量、血清铁蛋白与骨密度相关性研究.中华骨科杂志,2014,34(1):39-47.
[9]刘栋,孙永明,华俊,等.胸、腰椎骨质疏松性骨折患者椎体骨铁含量、血清铁蛋白与骨密度的相关性.中华骨质疏松和骨矿盐疾病杂志,2017,10(2):104-109.
[10]张勇,程晓光,于爱红,等.腰椎椎体骨髓脂肪含量与骨密度,年龄关系的定量影像评估.中华放射学杂志,2017,51(10):771-776.
[11]彭鹏,黄仲奎,龙莉玲,等.地中海贫血患者心脏、肝脏铁沉积的MRI定量研究.中华放射学杂志,2012,46(3):244-247.
[12]张晓东,赵文吉,陈焱君,等.腹部脂肪及年龄对女性腰椎骨质密度影响协同作用分析.中国医学影像学杂志,2016,25(11):843-846.
[13]Ojanen X,Borra RJ,Havu M,et al.Comparison of vertebral bone marrow fat assessed by 1H MRS and inphase and outof-phase MRI among family members.Osteoporos Int,2014,25(2):653-662.
[2]Blake GM,Griffith JF,Yeung DK,et al.Effect of increasing vertebral marrow fat content on BMD measurement,T-score status and fracture risk prediction by DXA.Bone,2009,44(3):495-501.
[3]李轶雯,袁慧书.磁共振脂肪定量技术在骨质疏松症中的应用.中国医学影像学杂志,2017,51(1):52-55.
[4]Shen W,Scherzer R,Gantz M,et al.Relationship between MRI-measured bone marrow adipose tissue and hip and spine bone mineral density in African-American and Caucasian participants:the CARDIA study.J Clin Endocrinol Metab,2012,97(4):1337-1346.
[5]Kühn JP,Hernando D,Meffert PJ,et al.Proton-density fat fraction and simultaneous R2*stimation as an MRI tool for assessment of osteoporosis.Eur Radiol,2013,23(12):3432-3439.
[6]Argyropoulou MI,Astrakas L.MRI evaluation of tissue Iron burden in patients withβ-thalassaemia major.Pediatr Radiol,2007,37(37):1191-1200.
[7]代岳,王姗,徐慧婷,等.IDEAL-IQ技术对不同年龄椎体骨髓脂肪含量的定量评价.中国医学计算机成像杂志,2017,23(2):161-165.
[8]张伟,王兵,张林林,等.绝经后股骨颈骨折股骨头骨铁含量、血清铁蛋白与骨密度相关性研究.中华骨科杂志,2014,34(1):39-47.
[9]刘栋,孙永明,华俊,等.胸、腰椎骨质疏松性骨折患者椎体骨铁含量、血清铁蛋白与骨密度的相关性.中华骨质疏松和骨矿盐疾病杂志,2017,10(2):104-109.
[10]张勇,程晓光,于爱红,等.腰椎椎体骨髓脂肪含量与骨密度,年龄关系的定量影像评估.中华放射学杂志,2017,51(10):771-776.
[11]彭鹏,黄仲奎,龙莉玲,等.地中海贫血患者心脏、肝脏铁沉积的MRI定量研究.中华放射学杂志,2012,46(3):244-247.
[12]张晓东,赵文吉,陈焱君,等.腹部脂肪及年龄对女性腰椎骨质密度影响协同作用分析.中国医学影像学杂志,2016,25(11):843-846.
[13]Ojanen X,Borra RJ,Havu M,et al.Comparison of vertebral bone marrow fat assessed by 1H MRS and inphase and outof-phase MRI among family members.Osteoporos Int,2014,25(2):653-662.