复发性流产的中西医研究进展
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摘要
近年,复发性流产发生率日益增多,免疫性因素导致的复发性流产也日益突出,已经引起临床的重视。复发性流产的不良生育现状是育龄期及高龄产妇所面临的严峻问题,所以在中西医两方面寻求一种安全有效的治疗方案是目前生殖医学科及妇产科亟待解决的问题。本文就近年来复发性流产的中西医临床研究进展进行了综述。
In recent years, the incidence of recurrent spontaneous abortion has increased, and recurrent abortion caused by immune factors has become increasingly prominent, which has drawn everyone 's attentioncon stantly. The poor fertility status of recurrent abortion is a serious situation faced by women in the reproductive period and older women. Therefore, seeking a safe and effective treatment plan in both traditional Chinese and Western medicine is an urgent problem to be solved in the reproductive medicine department and obstetrics and gynecology.This article reviews the recent advances in clinical research of traditional Chinese and Western medicine for recurrent spontaneous abortion in recent years.
In recent years, the incidence of recurrent spontaneous abortion has increased, and recurrent abortion caused by immune factors has become increasingly prominent, which has drawn everyone 's attentioncon stantly. The poor fertility status of recurrent abortion is a serious situation faced by women in the reproductive period and older women. Therefore, seeking a safe and effective treatment plan in both traditional Chinese and Western medicine is an urgent problem to be solved in the reproductive medicine department and obstetrics and gynecology.This article reviews the recent advances in clinical research of traditional Chinese and Western medicine for recurrent spontaneous abortion in recent years.
引文
[1]杜惠兰.中西医结合妇产科学[M].北京:中国中医药出版社,2012:235-241.
[2] Mei S,Tan J,Chen H,et al. Changes of CD4+CD25high regulatory T cells and FOXP3 expression in unexplained recurrent spontaneous abortion patients[J]. Fertil Steril,2010(94):2244-2247.
[3] Beaman KD,Ntrivalas E,Mallers TM,et al. Immune etiologyofrecurrent pregnancy loss and its diagnosis[J]. Am J Reprod Immunol,2012(67):319-325.
[4] Practice Committee of American Society for Reproductive Medicine.Definitions of infertility and recurrent pregnancy loss:a committee opinion[J].Fertil Steril,2013,99(1):63.
[5] Branch D W,Gibson M,Silver R M. Clinical practice.Recurrent miscarriage[J]. N Engl J Med,2010,363:1740-1747.
[6]张玉珍.中医妇科学[M].北京:中国中医药出版社,2011:219-224.
[7]沈华,韩丽娟,张文红.复发性流产的中医治疗进展[J].世界中西医结合杂志,2014,9(6):674-676.
[8]高冲,刘璐,胡爱菊,等.活血化瘀药的药理作用研究进展[J].药物评价研究,2013,36(1):64-68.
[9]郜洁,曾蕾,曹蕾,等.罗颂平教授治疗反复自然流产经验介绍[J].新中医,2008,40(11):12-14.
[10]徐峻苗,傅萍.中医药孕前调治对封闭抗体低下性复发性流产的影响[J].中华中医药学刊,2013,31(6):1311-1313.
[11]李静益,傅萍.傅萍治疗封闭抗体低下性复发性自然流产的经验[J].浙江中医杂志,2013,48(6):401.
[12]傅萍,周菲菲,盛晓园. 221例复发性流产患者中医证候分布规律研究[J].中华中医药学刊,2012,30(4):803-805.
[13]吕丽兰.安胎防漏汤治疗习惯性流产100例[J].实用中医药杂志,2013,29(6):437.
[14]白云.补肾化瘀法治疗原因不明复发性流产临床研究[J].辽宁中医药大学学报,2013,15(4):30-31.
[15]冯晓玲,杜昊,王玲.补肾活血方治疗Th1/Th2失衡不明原因复发性流产的应用研究[J].中医药学报,2013,41(3):140-141.
[16]刘娟,梁瑞宁,范培.补肾活血法对多囊卵巢综合征并复发性流产患者早期自然流产影响的临床观察[J].中国妇幼保健,2013,28(7):1150-1151.
[17]于宝萍.益肾固冲汤治疗胎漏胎动不安滑胎156例[J].光明中医,2013,28(6):1176-1178.
[18]李春梅.中医辨证治疗习惯性流产78例[J].中国民间疗法,2013,21(9):26.
[19]陆启滨.抗心磷脂抗体阳性先兆流产的病因病机探析[J].中华中医药学刊,2008,26(6):1127-1129.
[20]侯哲,孔欣,张婧辉,等.反复自然流产患者封闭抗体检测与免疫治疗分析[J].武警医学,2011,22(3):240-241.
[21]张艳华,刘梅梅,李佩玲.淋巴细胞主动免疫联合丙种球蛋白治疗复发性流产的研究[J].国际免疫杂志,2012,35(5):398-402.
[22]中华医学会风湿病学分会.抗磷脂综合征诊断和治疗指南[J].中华风湿病学杂志,2011,15(6):407-410.
[23] Alijotas-Reig J. Treatment of refractory obstetric antiphospholipid syndrome:the state of the art and new trends in the therapeutic man-agement[J]. Lupus,2013,22(1):6-17.
[24]鲍粉红,赵可宁.封闭抗体不足性反复自然流产治疗研究[J].长春中医药大学学报,2012,28(5):831-833.
[25]黄肖利,梅端容,黄毅. 218对反复自然流产或胚胎停育史夫妇细胞遗传学分析[J].国际检验医学杂志,2013,34(22):3021,3023.
[26]俞菁,龚波,侯雅萍,等.自然流产夫妇人群中染色体平衡易位与倒位的临床分析[J].中国优生与遗传杂志,2016,24(4):54-56.
[27] Acien P.Reproductive performance ofwomen with uterine malformations[J].Hum Peprod,2013,8(1):122-126.
[28]周冒秀,付锦华.环孢素A治疗难治性免疫性复发性流产的可行性分析[J].中华临床医师杂志(电子版),2014,8(18):3376-3378.
[29]周先韦,李伟莉,汪春,等.补肾安胎冲剂联合免疫疗法治疗反复自然流产40例[J].安徽中医学院学报,2011,30(1):27-29.
[30]诸莉莉.异体淋巴细胞主动免疫治疗复发性流产护理观察[J].医学信息,2017,30(20):142-143.
[31]邹琳,彭彩玲,许丽华,等. 321例复发性流产患者采用丈夫或无关个体淋巴细胞免疫治疗的临床分析[J].中国妇幼保健,2014,29(24):3951-3952.
[32]麦明琴,吴菁,魏然,等.复发性流产的免疫治疗效果分析[J].中国优生与遗传杂志,2010,18(7):68-69.
[33]董枫.免疫治疗反复自然流产的效果分析[J].中国实用医药,2014,9(13):124-125.
[34] Calleja-Agius J. Brincat MP. Recurrent miscarriages:what is the role of cytokines[J].Gynecol Endocfinol,2008,24(12):663-668.
[35] American college of obstetricians and gynecologists. ACOG practice bulletin NO.142:Cerclage for the management of cervical insuffiency[J].ObstetGynecol,2014,123(2):372-379.
[36]罗庚秋.中西医结合治疗习惯性流产的疗效观察[J].临床合理用药杂志,2013,6(3):78-79.
[37]中华医学会内分泌分会.妊娠和产后甲状腺疾病诊疗指南[J].中华内分泌代谢杂志,2012,28(5):353-367.
[38] Kiesewetter H,Radtke H,Becker R,et a1. Risk pregnancies and how to treat them[J]. Hamostaseologie,2012,32:90-94.
[39] Nakano Y,Akechi T,Furukawa T A,et a1. Cognitive behavior therapy for psychological distress in patients withrecurrentmiscarriage[J]. Psychol Res Behav Manag,2013,6(19):37-43.
[2] Mei S,Tan J,Chen H,et al. Changes of CD4+CD25high regulatory T cells and FOXP3 expression in unexplained recurrent spontaneous abortion patients[J]. Fertil Steril,2010(94):2244-2247.
[3] Beaman KD,Ntrivalas E,Mallers TM,et al. Immune etiologyofrecurrent pregnancy loss and its diagnosis[J]. Am J Reprod Immunol,2012(67):319-325.
[4] Practice Committee of American Society for Reproductive Medicine.Definitions of infertility and recurrent pregnancy loss:a committee opinion[J].Fertil Steril,2013,99(1):63.
[5] Branch D W,Gibson M,Silver R M. Clinical practice.Recurrent miscarriage[J]. N Engl J Med,2010,363:1740-1747.
[6]张玉珍.中医妇科学[M].北京:中国中医药出版社,2011:219-224.
[7]沈华,韩丽娟,张文红.复发性流产的中医治疗进展[J].世界中西医结合杂志,2014,9(6):674-676.
[8]高冲,刘璐,胡爱菊,等.活血化瘀药的药理作用研究进展[J].药物评价研究,2013,36(1):64-68.
[9]郜洁,曾蕾,曹蕾,等.罗颂平教授治疗反复自然流产经验介绍[J].新中医,2008,40(11):12-14.
[10]徐峻苗,傅萍.中医药孕前调治对封闭抗体低下性复发性流产的影响[J].中华中医药学刊,2013,31(6):1311-1313.
[11]李静益,傅萍.傅萍治疗封闭抗体低下性复发性自然流产的经验[J].浙江中医杂志,2013,48(6):401.
[12]傅萍,周菲菲,盛晓园. 221例复发性流产患者中医证候分布规律研究[J].中华中医药学刊,2012,30(4):803-805.
[13]吕丽兰.安胎防漏汤治疗习惯性流产100例[J].实用中医药杂志,2013,29(6):437.
[14]白云.补肾化瘀法治疗原因不明复发性流产临床研究[J].辽宁中医药大学学报,2013,15(4):30-31.
[15]冯晓玲,杜昊,王玲.补肾活血方治疗Th1/Th2失衡不明原因复发性流产的应用研究[J].中医药学报,2013,41(3):140-141.
[16]刘娟,梁瑞宁,范培.补肾活血法对多囊卵巢综合征并复发性流产患者早期自然流产影响的临床观察[J].中国妇幼保健,2013,28(7):1150-1151.
[17]于宝萍.益肾固冲汤治疗胎漏胎动不安滑胎156例[J].光明中医,2013,28(6):1176-1178.
[18]李春梅.中医辨证治疗习惯性流产78例[J].中国民间疗法,2013,21(9):26.
[19]陆启滨.抗心磷脂抗体阳性先兆流产的病因病机探析[J].中华中医药学刊,2008,26(6):1127-1129.
[20]侯哲,孔欣,张婧辉,等.反复自然流产患者封闭抗体检测与免疫治疗分析[J].武警医学,2011,22(3):240-241.
[21]张艳华,刘梅梅,李佩玲.淋巴细胞主动免疫联合丙种球蛋白治疗复发性流产的研究[J].国际免疫杂志,2012,35(5):398-402.
[22]中华医学会风湿病学分会.抗磷脂综合征诊断和治疗指南[J].中华风湿病学杂志,2011,15(6):407-410.
[23] Alijotas-Reig J. Treatment of refractory obstetric antiphospholipid syndrome:the state of the art and new trends in the therapeutic man-agement[J]. Lupus,2013,22(1):6-17.
[24]鲍粉红,赵可宁.封闭抗体不足性反复自然流产治疗研究[J].长春中医药大学学报,2012,28(5):831-833.
[25]黄肖利,梅端容,黄毅. 218对反复自然流产或胚胎停育史夫妇细胞遗传学分析[J].国际检验医学杂志,2013,34(22):3021,3023.
[26]俞菁,龚波,侯雅萍,等.自然流产夫妇人群中染色体平衡易位与倒位的临床分析[J].中国优生与遗传杂志,2016,24(4):54-56.
[27] Acien P.Reproductive performance ofwomen with uterine malformations[J].Hum Peprod,2013,8(1):122-126.
[28]周冒秀,付锦华.环孢素A治疗难治性免疫性复发性流产的可行性分析[J].中华临床医师杂志(电子版),2014,8(18):3376-3378.
[29]周先韦,李伟莉,汪春,等.补肾安胎冲剂联合免疫疗法治疗反复自然流产40例[J].安徽中医学院学报,2011,30(1):27-29.
[30]诸莉莉.异体淋巴细胞主动免疫治疗复发性流产护理观察[J].医学信息,2017,30(20):142-143.
[31]邹琳,彭彩玲,许丽华,等. 321例复发性流产患者采用丈夫或无关个体淋巴细胞免疫治疗的临床分析[J].中国妇幼保健,2014,29(24):3951-3952.
[32]麦明琴,吴菁,魏然,等.复发性流产的免疫治疗效果分析[J].中国优生与遗传杂志,2010,18(7):68-69.
[33]董枫.免疫治疗反复自然流产的效果分析[J].中国实用医药,2014,9(13):124-125.
[34] Calleja-Agius J. Brincat MP. Recurrent miscarriages:what is the role of cytokines[J].Gynecol Endocfinol,2008,24(12):663-668.
[35] American college of obstetricians and gynecologists. ACOG practice bulletin NO.142:Cerclage for the management of cervical insuffiency[J].ObstetGynecol,2014,123(2):372-379.
[36]罗庚秋.中西医结合治疗习惯性流产的疗效观察[J].临床合理用药杂志,2013,6(3):78-79.
[37]中华医学会内分泌分会.妊娠和产后甲状腺疾病诊疗指南[J].中华内分泌代谢杂志,2012,28(5):353-367.
[38] Kiesewetter H,Radtke H,Becker R,et a1. Risk pregnancies and how to treat them[J]. Hamostaseologie,2012,32:90-94.
[39] Nakano Y,Akechi T,Furukawa T A,et a1. Cognitive behavior therapy for psychological distress in patients withrecurrentmiscarriage[J]. Psychol Res Behav Manag,2013,6(19):37-43.