膳食纤维和肠道菌群与肥胖关系的研究进展
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摘要
肥胖症是很多疾病的危险因素,对社会造成严重的经济负担。既往对肥胖症的研究主要集中于相关并发症的预防,对肥胖本身的预防重视不足。近年来,随着宏基因组学的发展,人们逐渐认识到膳食纤维、肠道菌群与肥胖之间的关联性,尤其是因果关系及其产生的分子机制和基因水平的变化。随着人们生活水平的提高,膳食结构和肠道菌群的改变以及更多膳食结构的选择使膳食纤维和肠道菌群对预防肥胖的作用备受关注。
Obesity is a risk factor for many diseases,which causes serious economic burden to society. Previous studies on obesity mainly focused on the prevention of related complications,while insufficient attention was paid to the prevention of obesity itself. In recent years,with the development of macrogenomics,people have gradually realized the relationship between dietary fiber,intestinal flora and obesity,especially the causal relationship,its molecular mechanism and gene level changes. With the improvement of living standards,the changes of dietary structure and intestinal flora,and more choices of dietary structures,the role of dietary fiber and intestinal flora in preventing obesity has attracted much attention.
Obesity is a risk factor for many diseases,which causes serious economic burden to society. Previous studies on obesity mainly focused on the prevention of related complications,while insufficient attention was paid to the prevention of obesity itself. In recent years,with the development of macrogenomics,people have gradually realized the relationship between dietary fiber,intestinal flora and obesity,especially the causal relationship,its molecular mechanism and gene level changes. With the improvement of living standards,the changes of dietary structure and intestinal flora,and more choices of dietary structures,the role of dietary fiber and intestinal flora in preventing obesity has attracted much attention.
引文
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[18]Turnbaugh PJ,Ley RE,Mahowald MA,et al.An obesity-associated gut microbiome with increased capacity for energy harvest[J].Nature,2006,444(7122):1027-1031.
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[26]Wu GD,Compher C,Chen EZ,et al.Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production[J].Gut,2016,65(1):63-72.
[27]De Filippo C,Cavalieri D,Di Paola M,et al.Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa[J].Proc Natl Acad Sci U S A,2010,107(33):14691-14696.
[28]Rampelli S,Schnorr SL,Consolandi C,et al.Metagenome Sequencing of the Hadza Hunter-Gatherer Gut Microbiota[J].Curr Biol,2015,25(13):1682-1693.
[29]Guo Y,Wang Z,Chen L,et al.Diet induced maternal obesity affects offspring gut microbiota and persists into young adulthood[J].Food Funct,2018,9(8):4317-4327.
[30]Sonnenburg JL,Xu J,Leip DD,et al.Glycan foraging in vivo by an intestine-adapted bacterial symbiont[J].Science,2005,307(5717):1955-1959.
[31]Fernandes J,Su W,Rahat-Rozenbloom S,et al.Adiposity,gut microbiota and faecal short chain fatty acids are linked in adult humans[J].Nutr Diabetes,2014,4:e121.
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[33]Lin HV,Frassetto A,Kowalik EJ Jr,et al.Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms[J].PLo SOne,2012,7(4):e35240.
[34]Braune J,Weyer U,Hobusch C,et al.IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity[J].J Immunol,2017,198(7):2927-2934.
[35]Mengel E,Tillmann V,Remmel L,et al.Changes in inflammatory markers in estonian pubertal boys with different BMI values and increments:A 3-Year Follow-Up Study[J].Obesity(Silver Spring),2017,25(3):600-607.
[36]Bidu C,Escoula Q,Bellenger S,et al.The Transplantation ofω3PUFA-Altered Gut Microbiota of fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders[J].Diabetes,2018,67(8):1512-1523.
[37]Brahe LK,Astrup A,Larsen LH.Is butyrate the link between diet,intestinal microbiota and obesity-related metabolic diseases?[J].Obes Rev,2013,14(12):950-959.
[38]Louis P,Young P,Holtrop G,et al.Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyrylCoA:Acetate CoA-transferase gene[J].Environ Microbiol,2010,12(2):304-314.
[39]Cani PD,Possemiers S,Van de Wiele T,et al.Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability[J].Gut,2009,58(8):1091-1103.
[40]Zou J,Chassaing B,Singh V,et al.Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health[J].Cell Host Microbe,2018,10,23(1):41-53.e4.
[41]Kang Y,Li Y,Du Y,et al.Konjaku flour reduces obesity in mice by modulating the composition of the gut microbiota[J].Int JObes(Lond),2018.[2018-10-16].https://www.nature.com/articles/s41366-018-0187-x.[published online ahead of Sep 21,2018].
[42]Rojano-Rodriguez ME,Beristain-Hernandez JL,Zavaleta-Villa B,et al.Leptin receptor gene polymorphisms and morbid obesity in Mexican patients[J].Hereditas,2016,153:2.
[43]Hsiao TJ,Lin E.Association of a common rs9939609 variant in the fat mass and obesity-associated(FTO)gene with obesity and metabolic phenotypes in a Taiwanese population:A replication study[J].J Genet,2016,95(3):595-601.
[44]Drew JE,Reichardt N,Williams LM,et al.Dietary fibers inhibit obesity in mice,but host responses in the cecum and liver appear unrelated to fiber-specific changes in cecal bacterial taxonomic composition[J].Sci Rep,2018,8(1):15566.
[45]Lu HY,Zeng H,Zhang L,et al.Fecal fermentation products of common bean-derived fiber inhibit C/EBPαand PPARγexpression and lipid accumulation but stimulate PPARδand UCP2 expression in the adipogenesis of 3T3-L1 cells[J].J Nutr Biochem,2018,60:9-15.
[46]Bendall CL,Mayr HL,Opie RS,et al.Central obesity and the Mediterranean diet:A systematic review of intervention trials[J].Crit Rev Food Sci Nutr,2017,17:1-15.
[47]Bonaccio M,Di Castelnuovo A,Costanzo S,et al.Nutrition knowledge is associated with higher adherence to Mediterranean diet and lower prevalence of obesity.Results from the Moli-sani study[J].Appetite,2013,68:139-146.
[48]Garcia-Mantrana I,Selma-Royo M,Alcantara C,et al.Shifts on Gut Microbiota Associated to Mediterranean Diet Adherence and Specific Dietary Intakes on General Adult Population[J].Front Microbiol,2018,9:890.
[2]Friedrich MJ.Assessing and Addressing Global Malnutrition[J].JAMA,2015,313(3):235.
[3]Van Gaal LF,Maggioni AP.Overweight,obesity,and outcomes:Fat mass and beyond[J].Lancet,2014,383(9921):935-936.
[4]Shihab HM,Meoni LA,Chu AY,et al.Body mass index and risk of incident hypertension over the life course:The Johns Hopkins Precursors Study[J].Circulation,2012,126(25):2983-2989.
[5]Abdullah A,Peeters A,de Courten M,et al.The magnitude of association between overweight and obesity and the risk of diabetes:A meta-analysis of prospective cohort studies[J].Diabetes Res Clin Pract,2010,89(3):309-319.
[6]Bhaskaran K,Douglas I,Forbes H,et al.Body-mass index and risk of 22 specific cancers:A population-based cohort study of5.24 million UK adults[J].Lancet,2014,384(9945):755-765.
[7]Grover SA,Kaouache M,Rempel P,et al.Years of life lost and healthy life-years lost from diabetes and cardiovascular disease in overweight and obese people:A modelling study[J].Lancet Diabetes Endocrinol,2015,3(2):114-122.
[8]Tucker LA,Thomas KS.Increasing total fiber intake reduces risk of weight and fat gains in women[J].J Nutr,2009,139(3):576-581.
[9]Zhang J,Wang H,Wang Y,et al.Dietary patterns and their associations with childhood obesity in China[J].Br J Nutr,2015,113(12):1978-1984.
[10]Franzosa EA,Hsu T,Sirota-Madi A,et al.Sequencing and beyond:Integrating molecular`omics'for microbial community profiling[J].Nat Rev Microbiol,2015,13(6):360-372.
[11]Di Baise JK,Frank DN,Mathur R,et al.Impact of the gut microbiota on the development of obesity:Current concepts[J].Am J Gastroenterol,2012,Suppl 1(1):22-27.
[12]Thompson SV,Hannon BA,An R,et al.Effects of isolated soluble fiber supplementation on body weight,glycemia,and insulinemia in adults with overweight and obesity:A systematic review and meta-analysis of randomized controlled trials[J].Am J Clin Nutr,2017,106(6):1514-1528.
[13]Bckhed F,Manchester JK,Semenkovich CF,et al.Mechanisms underlying the resistance to diet-induced obesity in germ-free mice[J].Proc Natl Acad Sci U S A,2007,104(3):979-984.
[14]Lin Y,Huybrechts I,Vereecken C,et al.Dietary fiber intake and its association with indicators of adiposity and serum biomarkers in European adolescents:The HELENA study[J].Eur J Nutr,2015,54(5):771-782.
[15]Haller D,H9rmannsperger G.Interaction between humans and intestinal bacteria as a determinant for intestinal health:Intestinal microbiome and inflammatory bowel diseases[J].Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz,2015,58(2):159-165.
[16]Tabibian JH,Varghese C,LaRusso NF,et al.The enteric microbiome in hepatobiliary health and disease[J].Liver Int,2016,36(4):480-487.
[17]Turnbaugh PJ,Hamady M,Yatsunenko T,et al.A core gut microbiome in obese and lean twins[J].Nature,2009,457(7228):480-484.
[18]Turnbaugh PJ,Ley RE,Mahowald MA,et al.An obesity-associated gut microbiome with increased capacity for energy harvest[J].Nature,2006,444(7122):1027-1031.
[19]Thaiss CA,Itav S,Rothschild D,et al.Persistent microbiome alterations modulate the rate of post-dieting weight regain[J/OL].Nature,2016.[2018-05-15].https://www.nature.com/articles/nature20796.[published online ahead of Nov 24,2016].
[20]Borgeraas H,Johnson LK,Skattebu J,et al.Effects of probiotics on body weight,body mass index,fat mass and fat percentage in subjects with overweight or obesity:A systematic review and metaanalysis of randomized controlled trials[J].Obes Rev,2018,19(2):219-232.
[21]Miller DS,Mumford P,Stock MJ.Gluttony.2.Thermogenesis in overeating man[J].Am J Clin Nutr,1967,20(11):1223-1229.
[22]Walker AW,Ince J,Duncan SH,et al.Dominant and diet-responsive groups of bacteria within the human colonic microbiota[J].ISME J,2011,5(2):220-230.
[23]Wu GD,Chen J,Hoffmann C,et al.Linking long-term dietary patterns with gut microbial enterotypes[J].Science,2011,334(6052):105-108.
[24]John GK,Wang L,Nanavati J,et al.Dietary Alteration of the Gut Microbiome and Its Impact on Weight and Fat Mass:A Systematic Review and Meta-Analysis[J].Genes(Basel),2018,9(3).pii:E167.
[25]David LA,Maurice CF,Carmody RN,et al.Diet rapidly and reproducibly alters the human gut microbiome[J].Nature,2014,505(7484):559-563.
[26]Wu GD,Compher C,Chen EZ,et al.Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production[J].Gut,2016,65(1):63-72.
[27]De Filippo C,Cavalieri D,Di Paola M,et al.Impact of diet in shaping gut microbiota revealed by a comparative study in children from Europe and rural Africa[J].Proc Natl Acad Sci U S A,2010,107(33):14691-14696.
[28]Rampelli S,Schnorr SL,Consolandi C,et al.Metagenome Sequencing of the Hadza Hunter-Gatherer Gut Microbiota[J].Curr Biol,2015,25(13):1682-1693.
[29]Guo Y,Wang Z,Chen L,et al.Diet induced maternal obesity affects offspring gut microbiota and persists into young adulthood[J].Food Funct,2018,9(8):4317-4327.
[30]Sonnenburg JL,Xu J,Leip DD,et al.Glycan foraging in vivo by an intestine-adapted bacterial symbiont[J].Science,2005,307(5717):1955-1959.
[31]Fernandes J,Su W,Rahat-Rozenbloom S,et al.Adiposity,gut microbiota and faecal short chain fatty acids are linked in adult humans[J].Nutr Diabetes,2014,4:e121.
[32]Louis P,Scott KP,Duncan SH,et al.Understanding the effects of diet on bacterial metabolism in the large intestine[J].J Appl Microbiol,2007,102(5):1197-1208.
[33]Lin HV,Frassetto A,Kowalik EJ Jr,et al.Butyrate and propionate protect against diet-induced obesity and regulate gut hormones via free fatty acid receptor 3-independent mechanisms[J].PLo SOne,2012,7(4):e35240.
[34]Braune J,Weyer U,Hobusch C,et al.IL-6 Regulates M2 Polarization and Local Proliferation of Adipose Tissue Macrophages in Obesity[J].J Immunol,2017,198(7):2927-2934.
[35]Mengel E,Tillmann V,Remmel L,et al.Changes in inflammatory markers in estonian pubertal boys with different BMI values and increments:A 3-Year Follow-Up Study[J].Obesity(Silver Spring),2017,25(3):600-607.
[36]Bidu C,Escoula Q,Bellenger S,et al.The Transplantation ofω3PUFA-Altered Gut Microbiota of fat-1 Mice to Wild-Type Littermates Prevents Obesity and Associated Metabolic Disorders[J].Diabetes,2018,67(8):1512-1523.
[37]Brahe LK,Astrup A,Larsen LH.Is butyrate the link between diet,intestinal microbiota and obesity-related metabolic diseases?[J].Obes Rev,2013,14(12):950-959.
[38]Louis P,Young P,Holtrop G,et al.Diversity of human colonic butyrate-producing bacteria revealed by analysis of the butyrylCoA:Acetate CoA-transferase gene[J].Environ Microbiol,2010,12(2):304-314.
[39]Cani PD,Possemiers S,Van de Wiele T,et al.Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability[J].Gut,2009,58(8):1091-1103.
[40]Zou J,Chassaing B,Singh V,et al.Fiber-Mediated Nourishment of Gut Microbiota Protects against Diet-Induced Obesity by Restoring IL-22-Mediated Colonic Health[J].Cell Host Microbe,2018,10,23(1):41-53.e4.
[41]Kang Y,Li Y,Du Y,et al.Konjaku flour reduces obesity in mice by modulating the composition of the gut microbiota[J].Int JObes(Lond),2018.[2018-10-16].https://www.nature.com/articles/s41366-018-0187-x.[published online ahead of Sep 21,2018].
[42]Rojano-Rodriguez ME,Beristain-Hernandez JL,Zavaleta-Villa B,et al.Leptin receptor gene polymorphisms and morbid obesity in Mexican patients[J].Hereditas,2016,153:2.
[43]Hsiao TJ,Lin E.Association of a common rs9939609 variant in the fat mass and obesity-associated(FTO)gene with obesity and metabolic phenotypes in a Taiwanese population:A replication study[J].J Genet,2016,95(3):595-601.
[44]Drew JE,Reichardt N,Williams LM,et al.Dietary fibers inhibit obesity in mice,but host responses in the cecum and liver appear unrelated to fiber-specific changes in cecal bacterial taxonomic composition[J].Sci Rep,2018,8(1):15566.
[45]Lu HY,Zeng H,Zhang L,et al.Fecal fermentation products of common bean-derived fiber inhibit C/EBPαand PPARγexpression and lipid accumulation but stimulate PPARδand UCP2 expression in the adipogenesis of 3T3-L1 cells[J].J Nutr Biochem,2018,60:9-15.
[46]Bendall CL,Mayr HL,Opie RS,et al.Central obesity and the Mediterranean diet:A systematic review of intervention trials[J].Crit Rev Food Sci Nutr,2017,17:1-15.
[47]Bonaccio M,Di Castelnuovo A,Costanzo S,et al.Nutrition knowledge is associated with higher adherence to Mediterranean diet and lower prevalence of obesity.Results from the Moli-sani study[J].Appetite,2013,68:139-146.
[48]Garcia-Mantrana I,Selma-Royo M,Alcantara C,et al.Shifts on Gut Microbiota Associated to Mediterranean Diet Adherence and Specific Dietary Intakes on General Adult Population[J].Front Microbiol,2018,9:890.