促精宝汤治疗弱精症65例临床观察
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摘要
目的:探讨促精宝汤治疗弱精症的临床疗效及其作用机制。方法:将131例弱精症患者随机分为2组,治疗组65例采用促精宝汤治疗,对照组66例采用复方玄驹胶囊治疗。结果:总有效率治疗组为90. 8%,对照组为81. 8%,组间比较,差异有统计学意义(P <0. 05);治疗组在改善患者精液量、精子密度、精子活率、a级精子和b级精子、精浆超氧化物歧化酶同工酶(SOD)、丙二醛(MDA)、一氧化氮(NO)含量等方面均明显优于对照组,差异均有统计学意义(P <0. 05)。结论:促精宝汤治疗弱精症的临床疗效显著,其作用机制可能与提高SOD含量、降低MDA与NO的表达有关。
Objective: To investigate the clinical effect of Cujingbao decoction in the treatment of asthenozoospermia and its mechanism of action. Methods: A total of 131 patients with asthenozoospermia were divided into treatment group with 65 patients and control group with 66 patients. The patients in the treatment group were given Cujingbao decoction,and those in the control group were given compound Xuanju capsules. Results: There was a significant difference in overall response rate between the treatment group and the control group( 90. 8% vs81. 8%,P < 0. 05). Compared with the control group,the treatment group had significantly greater improvements in semen volume,sperm density,sperm motility rate,the numbers of grade A and B sperms,and the content of superoxide dismutase( SOD),malondialdehyde( MDA),and nitric oxide( NO) in seminal plasma( P < 0. 05). Conclusion:Cujingbao decoction has a marked clinical effect in the treatment of asthenozoospermia,possibly by increasing the content of SOD and reducing the expression of MDA and NO.
Objective: To investigate the clinical effect of Cujingbao decoction in the treatment of asthenozoospermia and its mechanism of action. Methods: A total of 131 patients with asthenozoospermia were divided into treatment group with 65 patients and control group with 66 patients. The patients in the treatment group were given Cujingbao decoction,and those in the control group were given compound Xuanju capsules. Results: There was a significant difference in overall response rate between the treatment group and the control group( 90. 8% vs81. 8%,P < 0. 05). Compared with the control group,the treatment group had significantly greater improvements in semen volume,sperm density,sperm motility rate,the numbers of grade A and B sperms,and the content of superoxide dismutase( SOD),malondialdehyde( MDA),and nitric oxide( NO) in seminal plasma( P < 0. 05). Conclusion:Cujingbao decoction has a marked clinical effect in the treatment of asthenozoospermia,possibly by increasing the content of SOD and reducing the expression of MDA and NO.
引文
[1]石安惠,牟杰,聂滨.少弱精症不育患者和正常生育男性的精浆生化结果分析[J].中国现代医生,2009,47(31):4-5,8.
[2]曹亮,马静,杨倩倩,等.补肾法治疗少弱精症的系统评价[J].中医药导报,2016,22(23):77-84.
[3]徐福平,张栋武,罗家怡,等.中医治疗弱精症患者与精子活动力的临床研究[J].中国医学创新,2017,14(20):85-89.
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[11]马亮,刘华剑,南亚昀,等.金匮肾气丸对腺嘌呤致不育大鼠精子质量与肾脏功能的影响[J].中国实验方剂学杂志,2011,17(8):184-186.
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[13]王忠民,王明闯,张菲菲.促精宝胶囊治疗弱精症临床疗效观察[J].世界中西医结合杂志,2014,9(1):82-85.
[14]张子钰,姜辉,安春娜,等.中国弱精症患者精液氧化损伤评价[J].中国新药杂志,2013,22(13):1556-1559,1570.
[15]金保方.聚精丸对弱精症精液NO、SOD、M2(细胞成分DNA)的作用机制研究[D]:南京:南京中医药大学,2004.
[16]徐洋涛,张瑜,许跃军,等.复方玄驹胶囊对弱精症患者精液质量、精子功能形态及精浆一氧化氮水平的影响[J].中国医药导报,2017,14(5):121-124.
[17]王志峰.弱精症患者血清和精浆中NO对精子活力的影响[D].广州:暨南大学,2006.
[2]曹亮,马静,杨倩倩,等.补肾法治疗少弱精症的系统评价[J].中医药导报,2016,22(23):77-84.
[3]徐福平,张栋武,罗家怡,等.中医治疗弱精症患者与精子活动力的临床研究[J].中国医学创新,2017,14(20):85-89.
[4]袁卓珺,秦国政,张云龙,等. 86例少弱精症患者中医体质类型初探[J].云南中医中药杂志,2009,30(7):4-5.
[5]世界卫生组织.人类精液及精子-宫颈黏液相互作用实验室检验手册[M].北京:人民卫生出版社,2001:25.
[6]国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994.
[7]樊士申.地黄益精方治疗少精、弱精症138例[J].新中医,2007,39(5):62-63.
[8]李振华,曲夷.姜建国运用五子衍宗丸治疗弱精症经验[J].山东中医杂志,2017,36(5):396-397.
[9]张小庆,孙丹杰.五子衍宗丸联合复方玄驹胶囊治疗少弱精症患者30例疗效观察[J].中国性科学,2017,26(2):88-90.
[10]张春和,李焱风,秦国政,等.自拟黄地助育汤治疗少弱精症男性不育150例疗效观察[J].云南中医中药杂志,2013,34(4):33-34,89.
[11]马亮,刘华剑,南亚昀,等.金匮肾气丸对腺嘌呤致不育大鼠精子质量与肾脏功能的影响[J].中国实验方剂学杂志,2011,17(8):184-186.
[12]吴国琳,李天一,余国友,等.复方玄驹胶囊对不育症大鼠精子质量及生殖激素的影响[J].西部中医药,2013,26(2):12-14.
[13]王忠民,王明闯,张菲菲.促精宝胶囊治疗弱精症临床疗效观察[J].世界中西医结合杂志,2014,9(1):82-85.
[14]张子钰,姜辉,安春娜,等.中国弱精症患者精液氧化损伤评价[J].中国新药杂志,2013,22(13):1556-1559,1570.
[15]金保方.聚精丸对弱精症精液NO、SOD、M2(细胞成分DNA)的作用机制研究[D]:南京:南京中医药大学,2004.
[16]徐洋涛,张瑜,许跃军,等.复方玄驹胶囊对弱精症患者精液质量、精子功能形态及精浆一氧化氮水平的影响[J].中国医药导报,2017,14(5):121-124.
[17]王志峰.弱精症患者血清和精浆中NO对精子活力的影响[D].广州:暨南大学,2006.