摘要
目的:建立聚羟基烷酸酯可吸收骨钉、骨板细菌内毒素检查方法。方法:通过不同方法制备供试品浸提液,按《中国药典》2010年版(二部)细菌内毒素检查法进行试验。结果:聚羟基烷酸酯可吸收骨钉、骨板在0.2 g·m L~(-1)浓度37±1℃温度下浸提1 h对细菌内毒素检查无干扰。结论:采用细菌内毒素检查法检测聚羟基烷酸酯可吸收骨钉、骨板的细菌内毒素是可行的。
Objective: To establish bacterial endotoxin test for polyhydroxyalkanoates absorbable bone screws and bone plates. Methods: The samples were prepared by different methods and measured according to Ch P. 2010 VolumeⅡ. Results: There was no influence when the polyhydroxyalkanoates absorbable bone screws and bone plates were extracted with 1h at the concentration of 0.2 g˙m L-1 and in the temperature of 37±1℃ for bacterial endotoxin test. Conclusion: It is feasible to detect the polyhydroxyalkanoates absorbable bone screws and bone plates by the method of bacterial endotoxin test.
引文
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