猪流行性腹泻病毒及其卵黄抗体研究进展
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摘要
猪流行性腹泻病毒是引起仔猪病毒性腹泻甚至死亡的关键诱因,而安全高效的抗猪流行性腹泻病毒卵黄抗体具有降低仔猪腹泻率、死亡率等优点已应用于生猪养殖。本文总结了近年来猪流行性腹泻病毒的致病机理及其卵黄抗体的制备与应用效果的研究进展,为卵黄抗体在防治猪流行性腹泻上的应用提供理论基础和技术指导。
Porcine epidemic diarrhea virus is a key cause of viral diarrhea in and even death of piglets. Therefore, the safe and efficient anti-swine epidemic diarrhea virus, yolk antibody, has been proved to have the advantages of reducing the diarrhea rate and mortality of piglets, and has been widely used in pig breeding practice. In this paper, the results of researches on the pathogenic mechanism of piglet epidemic diarrhea virus and on the preparation and application of yolk antibody are summarized, which provides a theoretical basis and technical guidance for the prevention and treatment of swine epidemic diarrhea.
Porcine epidemic diarrhea virus is a key cause of viral diarrhea in and even death of piglets. Therefore, the safe and efficient anti-swine epidemic diarrhea virus, yolk antibody, has been proved to have the advantages of reducing the diarrhea rate and mortality of piglets, and has been widely used in pig breeding practice. In this paper, the results of researches on the pathogenic mechanism of piglet epidemic diarrhea virus and on the preparation and application of yolk antibody are summarized, which provides a theoretical basis and technical guidance for the prevention and treatment of swine epidemic diarrhea.
引文
[1] 罗银昌.猪流行性腹泻病的预防及治疗措施[J].今日畜牧兽医,2011(03):27-28.
[2] 谢志刚.猪流行性腹泻的诊断及其中西医疗法[J].今日畜牧兽医,2010(03):32.
[3] Li W,Li H,Liu Y,et al.New variants of porcine epidemic diarrhea virus,China,2011[J].Emerg Infect Dis,2012,18(8):1350-1353.
[4] Puranaveja S,Poolperm P,Lertwatcharasrakul P,et al.Chinese-like strain of porcine epidemic diarrhea virus,Thailand[J].Emerg Infect Dis,2009,15(7):1112-1115.
[5] Chen J,Sun D,Wang C,et al.Molecular characterization and phylogenetic analysis of membrane protein genes of porcine epidemic diarrhea virus isolates in China[J].VIRUS GENES,2008,36(2):355-364.
[6] Huang Y W,Dickerman A W,Piňeyro P,et al.Origin,evolution,and genotyping of emergent porcine epidemic diarrhea virus strains in the United States[J].Mbio,2013,4(5):713-737.
[7] 秦红丽.《猪病学》第八版已面世[J].畜牧兽医科技信息,2001(01):23.
[8] 张明,鞠明卫,戴画.猪流行性腹泻及其防治方法[J].中国畜牧兽医文摘,2014(11):171-172.
[9] Kocherhans R,Bridgen A,Ackermann M,et al.Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequence[J].Virus Genes,2001,23(2):137-144.
[10] Lee S,Lee C.Outbreak-related porcine epidemic diarrhea virus strains similar to US strains,South Korea,2013[J].Emerg Infect Dis,2014,20(7):1223-1226.
[11] Perlman S,Netland J.Coronaviruses post-SARS:update on replication and pathogenesis[J].Nat Rev Microbiol,2009,7(6):439-450.
[12] Brian D A,BARIC R S.Coronavirus genome structure and replication[J].Curr Top Microbiol Immunol,2005,287:1-30.
[13] Kang T J,Seo J E,Kim D H,et al.Cloning and sequence analysis of the Korean strain of spike gene of porcine epidemic diarrhea virus and expression of its neutralizing epitope in plants[J].Protein Expr Purif,2005,41(2):378-383.
[14] Lee D K K N.The N-terminal region of the porcine epidemic diarrhea virus spike protein is important for the receptor binding[J].Korean Journal of Microbiology & Biotechnology,2011.
[15] Chang S H,Bae J L,Kang T J,et al.Identification of the epitope region capable of inducing neutralizing antibodies against the porcine epidemic diarrhea virus[J].Mol Cells,2002,14(2):295-299.
[16] Lee D K,Park C K,Kim S H,et al.Heterogeneity in spike protein genes of porcine epidemic diarrhea viruses isolated in Korea[J].Virus Res,2010,149(2):175-182.
[17] Bosch B J,van der Zee R,de Haan C A,et al.The coronavirus spike protein is a class I virus fusion protein:structural and functional characterization of the fusion core complex[J].J Virol,2003,77(16):8801-8811.
[18] Chen Y,Shi Y,Deng H,et al.Characterization of the porcine epidemic diarrhea virus codon usage bias[J].Infect Genet Evol,2014,28:95-100.
[19] 刘政龙,柴家前,王金良,等.猪流行性腹泻病毒S1基因的截段克隆表达及其在卵黄抗体制备上的应用[J].中国兽医学报,2016(09):1489-1493.
[20] 姜艳平,葛俊伟,汪淼,等.猪流行性腹泻病毒S基因片段的原核表达及其表达产物的反应原性[J].中国兽医科学,2009(07):602-607.
[21] 李好磊,李叶珍,赵顾,等.猪流行性腹泻病毒N基因重组真核质粒构建及其表达[J].浙江农业学报,2017(07):1103-1109.
[22] 郑逢梅,赵军,霍金耀,等.PEDV流行株N基因主要抗原表位原核表达及ELISA方法的建立[J].中国兽医学报,2014(03):371-378.
[23] Li Y,Wu Q,Huang L,et al.An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine[J].Nat Commun,2018,9(1):3811.
[24] 李清晖.仔猪常见腹泻病的鉴别诊断与防治[J].畜牧与饲料科学,2014(09):113-114.
[25] 王靖,赵建国.中国卵黄抗体饲料添加剂的研究进展[J].中国畜牧兽医,2014(03):146-150.
[26] Lee E N,Sunwoo H H,Menninen K,et al.In vitro studies of chicken egg yolk antibody (IgY) against Salmonella enteritidis and Salmonella typhimurium[J].Poult Sci,2002,81(5):632-641.
[27] Spillner E,Braren I,Greunke K,et al.Avian IgY antibodies and their recombinant equivalents in research,diagnostics and therapy[J].Biologicals,2012,40(5):313-322.
[28] Xu Y,Li X,Jin L,et al.Application of chicken egg yolk immunoglobulins in the control of terrestrial and aquatic animal diseases:a review[J].Biotechnol Adv,2011,29(6):860-868.
[29] Mine Y,Kovacs-nolan J.Chicken egg yolk antibodies as therapeu-tics in enteric infectious disease:a review[J].J Med Food,2002,5(3):159-169.
[30] 程志燕.抗猪流行性腹泻病毒卵黄抗体治疗效果研究[J].农业与技术,2017(22):96.
[31] 李冰,张显浩,裴仉福,等.抗猪流行性腹泻病毒卵黄抗体的制备及应用[J].中国畜牧兽医,2014(10):68-72.
[32] 杜季梅.仔猪病毒性腹泻流行病学调查及卵黄抗体在PEDV防治中的应用[D].河南农业大学,2013.
[33] 刘文娟,吴健敏,陆芹章,等.抗猪病毒性腹泻卵黄抗体的研制及纯化[J].黑龙江畜牧兽医,2010(19):144-146.
[34] Michalczyk R,Unkefer C J,Bacik J P,et al.Chicken egg yolk antibodies,production and application[J].Springer Lab Manuals,2001,10(18):5673-5678.
[35] 胡青松,李吕木,张小飞,等.猪流行性腹泻病毒3种抗原卵黄抗体的制备[J].西北农林科技大学学报(自然科学版),2015(11):35-40.
[36] 雷丹,李安琪,罗素贤,等.抗猪流行性腹泻病毒变异株卵黄抗体的制备、纯化及其活性影响因素的研究[J].中国畜牧兽医,2018(08):2293-2302.
[37] Sun D B,Feng L,Shi H Y,et al.Spike protein region (aa 636789) of porcine epidemic diarrhea virus is essential for induction of neutralizing antibodies[J].Acta Virol,2007,51(3):149-156.
[38] Lee D H,Jeon Y S,Park C K,et al.Immunoprophylactic effect of chicken egg yolk antibody (IgY) against a recombinant S1 domain of the porcine epidemic diarrhea virus spike protein in piglets[J].Arch Virol,2015,160(9):2197-2207.
[39] Kweon C H,Kwon B J,Woo S R,et al.Immunoprophylactic effect of chicken egg yolk immunoglobulin (Ig Y) against porcine epidemic diarrhea virus (PEDV) in piglets.[J].Journal of Veterinary Medical Science,2000,62(9):961-964.
[40] 崔焕忠,姜海龙,张加力,等.抗猪传染性胃肠炎病毒与猪流行性腹泻病毒卵黄抗体制备及其临床应用研究[J].中国畜牧兽医,2012(06):173-175.
[41] 胡青松.抗猪腹泻卵黄抗体添加剂的初步研究[D].合肥:安徽农业大学,2014.
[42] 凌刚.抗PEDV高免卵黄抗体的制备及其初步应用[D].合肥:安徽农业大学,2016.
[43] 潘孝成,赵瑞宏,沈学怀,等.猪流行性腹泻病毒卵黄抗体的制备与应用[J].养猪,2016(03):119-120.
[44] 李冰,张显浩,裴仉福,等.抗猪流行性腹泻病毒卵黄抗体的制备及应用[J].中国畜牧兽医,2014(10):68-72.
[45] 宋维平,徐福洲,王金洛,等.抗猪流行性腹泻病毒卵黄抗体治疗效果研究[J].华北农学报,2003(01):114-115.
[46] 贺娟娟.抗猪流行性腹泻病毒高免卵黄抗体的制备及临床应用研究[J].当代畜禽养殖业,2018(03):10-11.
[47] 周正.抗猪流行性腹泻病毒卵黄抗体治疗效果研究[J].兽医导刊,2017(4):218.
[48] Mahdavi A H,Rahmani H R,Nili N,et al.Effects of dietary egg yolk antibody powder on growth performance,intestinal Escherichia coli colonization,and immunocompetence of challenged broiler chicks[J].Poult Sci,2010,89(3):484-494.
[2] 谢志刚.猪流行性腹泻的诊断及其中西医疗法[J].今日畜牧兽医,2010(03):32.
[3] Li W,Li H,Liu Y,et al.New variants of porcine epidemic diarrhea virus,China,2011[J].Emerg Infect Dis,2012,18(8):1350-1353.
[4] Puranaveja S,Poolperm P,Lertwatcharasrakul P,et al.Chinese-like strain of porcine epidemic diarrhea virus,Thailand[J].Emerg Infect Dis,2009,15(7):1112-1115.
[5] Chen J,Sun D,Wang C,et al.Molecular characterization and phylogenetic analysis of membrane protein genes of porcine epidemic diarrhea virus isolates in China[J].VIRUS GENES,2008,36(2):355-364.
[6] Huang Y W,Dickerman A W,Piňeyro P,et al.Origin,evolution,and genotyping of emergent porcine epidemic diarrhea virus strains in the United States[J].Mbio,2013,4(5):713-737.
[7] 秦红丽.《猪病学》第八版已面世[J].畜牧兽医科技信息,2001(01):23.
[8] 张明,鞠明卫,戴画.猪流行性腹泻及其防治方法[J].中国畜牧兽医文摘,2014(11):171-172.
[9] Kocherhans R,Bridgen A,Ackermann M,et al.Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequence[J].Virus Genes,2001,23(2):137-144.
[10] Lee S,Lee C.Outbreak-related porcine epidemic diarrhea virus strains similar to US strains,South Korea,2013[J].Emerg Infect Dis,2014,20(7):1223-1226.
[11] Perlman S,Netland J.Coronaviruses post-SARS:update on replication and pathogenesis[J].Nat Rev Microbiol,2009,7(6):439-450.
[12] Brian D A,BARIC R S.Coronavirus genome structure and replication[J].Curr Top Microbiol Immunol,2005,287:1-30.
[13] Kang T J,Seo J E,Kim D H,et al.Cloning and sequence analysis of the Korean strain of spike gene of porcine epidemic diarrhea virus and expression of its neutralizing epitope in plants[J].Protein Expr Purif,2005,41(2):378-383.
[14] Lee D K K N.The N-terminal region of the porcine epidemic diarrhea virus spike protein is important for the receptor binding[J].Korean Journal of Microbiology & Biotechnology,2011.
[15] Chang S H,Bae J L,Kang T J,et al.Identification of the epitope region capable of inducing neutralizing antibodies against the porcine epidemic diarrhea virus[J].Mol Cells,2002,14(2):295-299.
[16] Lee D K,Park C K,Kim S H,et al.Heterogeneity in spike protein genes of porcine epidemic diarrhea viruses isolated in Korea[J].Virus Res,2010,149(2):175-182.
[17] Bosch B J,van der Zee R,de Haan C A,et al.The coronavirus spike protein is a class I virus fusion protein:structural and functional characterization of the fusion core complex[J].J Virol,2003,77(16):8801-8811.
[18] Chen Y,Shi Y,Deng H,et al.Characterization of the porcine epidemic diarrhea virus codon usage bias[J].Infect Genet Evol,2014,28:95-100.
[19] 刘政龙,柴家前,王金良,等.猪流行性腹泻病毒S1基因的截段克隆表达及其在卵黄抗体制备上的应用[J].中国兽医学报,2016(09):1489-1493.
[20] 姜艳平,葛俊伟,汪淼,等.猪流行性腹泻病毒S基因片段的原核表达及其表达产物的反应原性[J].中国兽医科学,2009(07):602-607.
[21] 李好磊,李叶珍,赵顾,等.猪流行性腹泻病毒N基因重组真核质粒构建及其表达[J].浙江农业学报,2017(07):1103-1109.
[22] 郑逢梅,赵军,霍金耀,等.PEDV流行株N基因主要抗原表位原核表达及ELISA方法的建立[J].中国兽医学报,2014(03):371-378.
[23] Li Y,Wu Q,Huang L,et al.An alternative pathway of enteric PEDV dissemination from nasal cavity to intestinal mucosa in swine[J].Nat Commun,2018,9(1):3811.
[24] 李清晖.仔猪常见腹泻病的鉴别诊断与防治[J].畜牧与饲料科学,2014(09):113-114.
[25] 王靖,赵建国.中国卵黄抗体饲料添加剂的研究进展[J].中国畜牧兽医,2014(03):146-150.
[26] Lee E N,Sunwoo H H,Menninen K,et al.In vitro studies of chicken egg yolk antibody (IgY) against Salmonella enteritidis and Salmonella typhimurium[J].Poult Sci,2002,81(5):632-641.
[27] Spillner E,Braren I,Greunke K,et al.Avian IgY antibodies and their recombinant equivalents in research,diagnostics and therapy[J].Biologicals,2012,40(5):313-322.
[28] Xu Y,Li X,Jin L,et al.Application of chicken egg yolk immunoglobulins in the control of terrestrial and aquatic animal diseases:a review[J].Biotechnol Adv,2011,29(6):860-868.
[29] Mine Y,Kovacs-nolan J.Chicken egg yolk antibodies as therapeu-tics in enteric infectious disease:a review[J].J Med Food,2002,5(3):159-169.
[30] 程志燕.抗猪流行性腹泻病毒卵黄抗体治疗效果研究[J].农业与技术,2017(22):96.
[31] 李冰,张显浩,裴仉福,等.抗猪流行性腹泻病毒卵黄抗体的制备及应用[J].中国畜牧兽医,2014(10):68-72.
[32] 杜季梅.仔猪病毒性腹泻流行病学调查及卵黄抗体在PEDV防治中的应用[D].河南农业大学,2013.
[33] 刘文娟,吴健敏,陆芹章,等.抗猪病毒性腹泻卵黄抗体的研制及纯化[J].黑龙江畜牧兽医,2010(19):144-146.
[34] Michalczyk R,Unkefer C J,Bacik J P,et al.Chicken egg yolk antibodies,production and application[J].Springer Lab Manuals,2001,10(18):5673-5678.
[35] 胡青松,李吕木,张小飞,等.猪流行性腹泻病毒3种抗原卵黄抗体的制备[J].西北农林科技大学学报(自然科学版),2015(11):35-40.
[36] 雷丹,李安琪,罗素贤,等.抗猪流行性腹泻病毒变异株卵黄抗体的制备、纯化及其活性影响因素的研究[J].中国畜牧兽医,2018(08):2293-2302.
[37] Sun D B,Feng L,Shi H Y,et al.Spike protein region (aa 636789) of porcine epidemic diarrhea virus is essential for induction of neutralizing antibodies[J].Acta Virol,2007,51(3):149-156.
[38] Lee D H,Jeon Y S,Park C K,et al.Immunoprophylactic effect of chicken egg yolk antibody (IgY) against a recombinant S1 domain of the porcine epidemic diarrhea virus spike protein in piglets[J].Arch Virol,2015,160(9):2197-2207.
[39] Kweon C H,Kwon B J,Woo S R,et al.Immunoprophylactic effect of chicken egg yolk immunoglobulin (Ig Y) against porcine epidemic diarrhea virus (PEDV) in piglets.[J].Journal of Veterinary Medical Science,2000,62(9):961-964.
[40] 崔焕忠,姜海龙,张加力,等.抗猪传染性胃肠炎病毒与猪流行性腹泻病毒卵黄抗体制备及其临床应用研究[J].中国畜牧兽医,2012(06):173-175.
[41] 胡青松.抗猪腹泻卵黄抗体添加剂的初步研究[D].合肥:安徽农业大学,2014.
[42] 凌刚.抗PEDV高免卵黄抗体的制备及其初步应用[D].合肥:安徽农业大学,2016.
[43] 潘孝成,赵瑞宏,沈学怀,等.猪流行性腹泻病毒卵黄抗体的制备与应用[J].养猪,2016(03):119-120.
[44] 李冰,张显浩,裴仉福,等.抗猪流行性腹泻病毒卵黄抗体的制备及应用[J].中国畜牧兽医,2014(10):68-72.
[45] 宋维平,徐福洲,王金洛,等.抗猪流行性腹泻病毒卵黄抗体治疗效果研究[J].华北农学报,2003(01):114-115.
[46] 贺娟娟.抗猪流行性腹泻病毒高免卵黄抗体的制备及临床应用研究[J].当代畜禽养殖业,2018(03):10-11.
[47] 周正.抗猪流行性腹泻病毒卵黄抗体治疗效果研究[J].兽医导刊,2017(4):218.
[48] Mahdavi A H,Rahmani H R,Nili N,et al.Effects of dietary egg yolk antibody powder on growth performance,intestinal Escherichia coli colonization,and immunocompetence of challenged broiler chicks[J].Poult Sci,2010,89(3):484-494.