A comparative study of assembly and disassembly process of dimeric and monomeric cyanine dyes with DNA templates

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英文篇名：A comparative study of assembly and disassembly process of dimeric and monomeric cyanine dyes with DNA templates 作者：Lijia ; Yu ; Qianfan ; Yang ; Yalin ; Tang 英文作者：Lijia Yu;Qianfan Yang;Yalin Tang;National Center of Occupational Safety and Health,State Administration of Work Safety;College of Chemistry, Sichuan University;Beijing National Laboratory for Molecular Science, Center for Molecular Science, State Key Laboratory for Structural Chemistry for Unstable and State Species, Institute of Chemistry, Chinese Academy of Sciences; 英文关键词：Cyanine dye;;Supramolecular assembly;;DNA templates;;G-quadruplex;;c-myc 中文刊名：FXKB 英文刊名：中国化学快报(英文版) 机构：National Center of Occupational Safety and Health,State Administration of Work Safety;College of Chemistry, Sichuan University;Beijing National Laboratory for Molecular Science, Center for Molecular Science, State Key Laboratory for Structural Chemistry for Unstable and State Species, Institute of Chemistry, Chinese Academy of Sciences; 出版日期：2019-03-15 出版单位：Chinese Chemical Letters 年：2019 期：v.30 基金：financially supported by General Program of the National Natural Science Foundation of China(Nos. 21472197. 21675126 and 21778058);; "Science and Technology Service Network Initiative" of the Chinese Academy of Sciences 语种：英文; 页：FXKB201903036 页数：4 CN：03 ISSN：11-2710/O6 分类号：182-185

摘要

Cyanine dyes have attracted more and more interest due to their controllable assembly and disassembly process with biomolecular templates. The self-assembly of cyanine dye not only depend on the environment, but also on their structures. Here, we report assembly and disassembly of two cyanine dyes,a dimeric cyaine dye(TC-P4) and its corresponding monomer(TC). In PBS, these dyes could form aggregates. The parallel c-myc G-quadruplex as a template causes the transformation of TC-P4 from Haggregates to dimer and monomer; while duplex and single-stranded DNAs could not. The interaction between these DNAs motifs and TC could all induce the appearance of monomer band. Parallel c-myc Gquadruplex could enhance the fluorescence intensity of TC-P4 and TC. The self-assembly and disassembly of TC and TC-P4 could be regulated and used as probes for G-quadruplex recognition from duplex and single-stranded DNAs in solution.
        Cyanine dyes have attracted more and more interest due to their controllable assembly and disassembly process with biomolecular templates. The self-assembly of cyanine dye not only depend on the environment, but also on their structures. Here, we report assembly and disassembly of two cyanine dyes,a dimeric cyaine dye(TC-P4) and its corresponding monomer(TC). In PBS, these dyes could form aggregates. The parallel c-myc G-quadruplex as a template causes the transformation of TC-P4 from Haggregates to dimer and monomer; while duplex and single-stranded DNAs could not. The interaction between these DNAs motifs and TC could all induce the appearance of monomer band. Parallel c-myc Gquadruplex could enhance the fluorescence intensity of TC-P4 and TC. The self-assembly and disassembly of TC and TC-P4 could be regulated and used as probes for G-quadruplex recognition from duplex and single-stranded DNAs in solution.

引文

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