哺乳动物雌性生殖系统β-防御素的研究进展
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摘要
防御素(beta-defensian,BD)在哺乳动物雌性生殖系统中广泛表达,在免疫、预防生殖道感染及胎儿正常发育等方面起到重要作用。主要对哺乳动物β-防御素在哺乳动物雌性生殖系统组织中的分布、作用及其调控进行了综述,并对其应用前景进行了展望,以期更好地揭示β-防御素在雌性生殖系统中的影响,从而为β-防御素的进一步研究提供理论依据。
Beta-defensin has been found to be widely expressed in the female reproductive system of mammals, which plays an important role in immunity, prevention of reproductive tract infection and normal fetal development. In this paper, the distribution,function and regulation of beta-defensin in female mammalian reproductive system were reviewed, and its application was prospected, in hoping to provide references for better reveal the roles of beta-defensin in female reproductive system.
Beta-defensin has been found to be widely expressed in the female reproductive system of mammals, which plays an important role in immunity, prevention of reproductive tract infection and normal fetal development. In this paper, the distribution,function and regulation of beta-defensin in female mammalian reproductive system were reviewed, and its application was prospected, in hoping to provide references for better reveal the roles of beta-defensin in female reproductive system.
引文
[1]SUN C Q,ARNOLD R S,HSIEH C L,et al.Discovery and mechanisms of host defense to oncogenesis:targeting the beta-defensin-1 peptide as a natural tumor inhibitor[J],Cancer Biology and Therapy,2019,20(6):774-786.
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[3]杨银凤,唐博,余兴邦,等.β-防御素caBD-1 mRNA在骆驼组织器官中的表达[J].中国兽医科技,2004,34(11):5-8.
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[5]SHELDON I M,OWENS S E,TURNER M L.Innate immunity and the sensing of infection,damage and danger in the female genital tract[J].Journal of Reproductive Immunology,2017,119:67-73.
[6]白立恒,宋伟奇,游存厚,等.女性生殖道内β-防御素类型与作用[J].中国当代医药,2013,20(9):21-23.
[7]DAVIES D,MEADE K G,HERATH S,et al.Toll-like receptor and antimicrobial peptide expression in the bovine endometrium[J].Reproductive Biology and En-docrinology,2008;6(1):53.
[8]FOLEY C,CHAPWAN YA A,CALLANAN J J,et al.Integrated analysis of the local and systemic changes preceding the development of post-partum cytological endometritis[J].BMC Genomics,2015(16):811.
[9]SANG Y,ORTEGA M T,BLECHA F,et al.Molecular cloning and characterization of threeβ-defensins from canine testes[J].Infection and Immunity,2005,73(5):2611-2620.
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[11]ZU PIN L,POLESELLO V,MARTINELLI M,et al.Human beta-defensin 1 in follicular fluid and semen:impact on fertility[J].Journal of Assisted Reproduction and Genetics,2019,36(4):787-797.
[12]刘陶林,铁宇娟,艾显辉,等.哺乳动物雄性生殖系统β-防御素的研究进展[J].中国兽医科学,2018,48(11):1458-1463.
[13]LI Q,BAO F,ZHI D,et al.Lipopolysaccharide induces SBD-1 expression via the P38 MAPK signaling pathway in ovine oviduct epithelial cells[J].Lipids in Health and Disease,2016,15(1):127.
[14]FU Y,LIU B,FENG X,et al.Lipopolysaccharide increases Toll-like receptor 4 and downstream Toll-like receptor signaling molecules expression in bovine endometrial epithelial cells[J].V eterinary Immunology and Immunopathology,2013,151(2):20-27.
[15]WEN S,CAO G,BAO T,et al.Modulation of ovine SBD-1 expression by 17beta-estradiol in ovine oviduct epithelial cells[J].BMC Veterinary Research,2012,8:143.
[16]包图雅,曹贵方,凃勇,等.17β-雌二醇上调绵羊输卵管上皮细胞β-防御素-2(SBD-2)表达的可能信号通路研究[J].西北农林科技大学学报(自然科学版),2013,41(11):32-36.
[17]谢婧,游晓星,曾焱华,等.生殖支原体脂质相关膜蛋白诱导宫颈上皮细胞表达人β-防御素2[J].细胞与分子免疫学杂志,2014,30(12):1266-1270.
[18]孟炜,丁岩,王延蛟.人类-β防御素-1、-2、-3mRNA在女性非淋病奈瑟菌性宫颈炎中的表达及其临床意义[J].中国实用妇科与产科杂志,2013,29(7):574-578.
[19]GAO M Q,ZHANG R,YANG Y,et al.A subhronic feeding safety evaluation of transgenic milk containing human beta-defensin 3 on reproductive system of C57BL/6J mouse[J].Food and Chemical Toxicology,2018,115:198-204.
[20]XU D,ZHANG B,LIAO C,et al.Human beta-defensin3 contributes to the carcinogenesis of cervical cancer via activation of NF-kappaB signaling[J].Oncotarget,2016,7(46):75902-75913.
[21]FERN ANDEZ-FUERTES B,NARCIANDI F,O'FARRELLY C,et al.Cauda epididymis-specific beta-defensin 126 promotes sperm motility but not fertilizing ability in cattle[J].Biology of Reproduction,2016,95(6):122.
[2]KING A E,FLEMING D C,CRITCHLEY H 0,et al.Differential expression of the natural antimicrobials,betadefensins 3 and 4,in human endometrium[J].Journal of Reproductive Immunology,2003,59(1):1-16.
[3]杨银凤,唐博,余兴邦,等.β-防御素caBD-1 mRNA在骆驼组织器官中的表达[J].中国兽医科技,2004,34(11):5-8.
[4]HICKEY D K,FAHEY J V,WIRA C R.Mouse estrous cycle regulation of vaginal versus uterine cytokines,chemokines,alpha-/beta-defensins and TLRs[J].Innate Immunity,2013,19(2):121-131.
[5]SHELDON I M,OWENS S E,TURNER M L.Innate immunity and the sensing of infection,damage and danger in the female genital tract[J].Journal of Reproductive Immunology,2017,119:67-73.
[6]白立恒,宋伟奇,游存厚,等.女性生殖道内β-防御素类型与作用[J].中国当代医药,2013,20(9):21-23.
[7]DAVIES D,MEADE K G,HERATH S,et al.Toll-like receptor and antimicrobial peptide expression in the bovine endometrium[J].Reproductive Biology and En-docrinology,2008;6(1):53.
[8]FOLEY C,CHAPWAN YA A,CALLANAN J J,et al.Integrated analysis of the local and systemic changes preceding the development of post-partum cytological endometritis[J].BMC Genomics,2015(16):811.
[9]SANG Y,ORTEGA M T,BLECHA F,et al.Molecular cloning and characterization of threeβ-defensins from canine testes[J].Infection and Immunity,2005,73(5):2611-2620.
[10]CHEN R B,ZHANG K,ZHANG H,et al.Analysis of the antimicrobial mechanism of porcine beta defensin 2 against E.coli by electron microscopy and differentially expressed genes[J].Science Report,2018,8(1):14711.
[11]ZU PIN L,POLESELLO V,MARTINELLI M,et al.Human beta-defensin 1 in follicular fluid and semen:impact on fertility[J].Journal of Assisted Reproduction and Genetics,2019,36(4):787-797.
[12]刘陶林,铁宇娟,艾显辉,等.哺乳动物雄性生殖系统β-防御素的研究进展[J].中国兽医科学,2018,48(11):1458-1463.
[13]LI Q,BAO F,ZHI D,et al.Lipopolysaccharide induces SBD-1 expression via the P38 MAPK signaling pathway in ovine oviduct epithelial cells[J].Lipids in Health and Disease,2016,15(1):127.
[14]FU Y,LIU B,FENG X,et al.Lipopolysaccharide increases Toll-like receptor 4 and downstream Toll-like receptor signaling molecules expression in bovine endometrial epithelial cells[J].V eterinary Immunology and Immunopathology,2013,151(2):20-27.
[15]WEN S,CAO G,BAO T,et al.Modulation of ovine SBD-1 expression by 17beta-estradiol in ovine oviduct epithelial cells[J].BMC Veterinary Research,2012,8:143.
[16]包图雅,曹贵方,凃勇,等.17β-雌二醇上调绵羊输卵管上皮细胞β-防御素-2(SBD-2)表达的可能信号通路研究[J].西北农林科技大学学报(自然科学版),2013,41(11):32-36.
[17]谢婧,游晓星,曾焱华,等.生殖支原体脂质相关膜蛋白诱导宫颈上皮细胞表达人β-防御素2[J].细胞与分子免疫学杂志,2014,30(12):1266-1270.
[18]孟炜,丁岩,王延蛟.人类-β防御素-1、-2、-3mRNA在女性非淋病奈瑟菌性宫颈炎中的表达及其临床意义[J].中国实用妇科与产科杂志,2013,29(7):574-578.
[19]GAO M Q,ZHANG R,YANG Y,et al.A subhronic feeding safety evaluation of transgenic milk containing human beta-defensin 3 on reproductive system of C57BL/6J mouse[J].Food and Chemical Toxicology,2018,115:198-204.
[20]XU D,ZHANG B,LIAO C,et al.Human beta-defensin3 contributes to the carcinogenesis of cervical cancer via activation of NF-kappaB signaling[J].Oncotarget,2016,7(46):75902-75913.
[21]FERN ANDEZ-FUERTES B,NARCIANDI F,O'FARRELLY C,et al.Cauda epididymis-specific beta-defensin 126 promotes sperm motility but not fertilizing ability in cattle[J].Biology of Reproduction,2016,95(6):122.