复方聚乙二醇电解质散与西甲硅油在胶囊内镜肠道检查中的应用
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摘要
目的探讨复方聚乙二醇电解质散(PEG)与西甲硅油在胶囊内镜肠道检查前肠道准备应用效果。方法将2016年10月至2018年10月于江苏大学附属昆山市第一人民医院行胶囊内镜肠道检查的90例患者随机分为A组(PEG)与B组(PEG+西甲硅油),各45例。比较两组肠道清洁程度、肠道内气泡存在程度、胶囊通过胃及小肠的时间和不良反应发生率。结果两组肠道清洁程度比较,差异无统计学意义(P>0. 05)。B组肠道内气泡存在程度显著低于A组(P <0. 05)。B组胶囊通过胃、小肠的时间分别为(37. 60±8. 28) min、(280. 62±56. 33) min,显著短于A组的(45. 80±9. 13) min、(333. 58±67. 52) min,差异均有统计学意义(P <0. 05)分。B组不良反应发生率为6. 67%,显著低于A组的22. 22%(P <0. 05)。结论胶囊内镜检查前联合应用PEG与西甲硅油可有效祛除肠腔内气泡,获得良好的视野,缩短胶囊通过胃及小肠的时间,且不良反应发生率低,具有较高的应用安全性。
Objective To investigate the effect of polyethylene glycol-electrolyte( PEG) and simethicone in intestinal preparation before capsule endoscopy. Methods Ninety patients who underwent capsule endoscopy intestinal examination in ourhospital from October 2016 to October 2018 were randomly divided into group A( PEG) and group B( PEG with simethicone),45 cases in each group. The degree of intestinal cleanliness,the presence degree of bubble in the intestine,the passing time of capsule through the stomach and small intestine and the incidence of adverse reactions were compared between the two groups. Results There was no significant difference in degree of intestinal cleanliness between the two groups( P > 0. 05). The presence degree of intestinalin group B was significantly lower than that ingroup A( P < 0. 05). The passing time of capsule through the stomach and small intestine in group B was significantly shorter than that in group A[( 37. 60 ± 8. 28) min vs( 45. 80 ± 9. 13) min,( 280. 62 ± 56. 33) min vs( 333. 58 ±67. 52) min]( P < 0. 05). The incidence of adverse reactions in group B was significantly lower than that in group A( 6. 67% vs22. 22%)( P < 0. 05). Conclusion The combination application of PEG and simethicone in the intestinal preparation before capsule endoscopy effectively eliminate the bubbles in the intestine,obtain good vision,shorten the time of capsule passing through the stomach and small intestine,with low incidence of adverse reactions and high application safety.
Objective To investigate the effect of polyethylene glycol-electrolyte( PEG) and simethicone in intestinal preparation before capsule endoscopy. Methods Ninety patients who underwent capsule endoscopy intestinal examination in ourhospital from October 2016 to October 2018 were randomly divided into group A( PEG) and group B( PEG with simethicone),45 cases in each group. The degree of intestinal cleanliness,the presence degree of bubble in the intestine,the passing time of capsule through the stomach and small intestine and the incidence of adverse reactions were compared between the two groups. Results There was no significant difference in degree of intestinal cleanliness between the two groups( P > 0. 05). The presence degree of intestinalin group B was significantly lower than that ingroup A( P < 0. 05). The passing time of capsule through the stomach and small intestine in group B was significantly shorter than that in group A[( 37. 60 ± 8. 28) min vs( 45. 80 ± 9. 13) min,( 280. 62 ± 56. 33) min vs( 333. 58 ±67. 52) min]( P < 0. 05). The incidence of adverse reactions in group B was significantly lower than that in group A( 6. 67% vs22. 22%)( P < 0. 05). Conclusion The combination application of PEG and simethicone in the intestinal preparation before capsule endoscopy effectively eliminate the bubbles in the intestine,obtain good vision,shorten the time of capsule passing through the stomach and small intestine,with low incidence of adverse reactions and high application safety.
引文
[1]戈之铮,李兆申.中国胶囊内镜临床应用指南[J].中华消化内镜杂志,2014,19(10):606-617.
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[3]赵莉,许乐,刚锐,等.复方聚乙二醇电解质散对老年患者肠道准备效果的随机对照研究[J].中华消化内镜杂志,2015,32(3):164-166.
[4]赵金芳,朱良如,任宏宇,等.三种口服复方聚乙二醇电解质散方案进行肠道准备的比较研究[J].中华消化内镜杂志,2015,32(9):613-616.
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[6]吴东,李骥,杨红,等.隔夜分次服用聚乙二醇联合西甲硅油提高上午结肠镜检查质量的价值研究[J].中华消化内镜杂志,2016,33(11):751-755.
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[10]顾宇,姚运河.胶囊内镜用于小肠疾病诊断的策略[J].国际消化病杂志,2016,36(6):340-342.
[11]黄骏盛,赖华生,农艳瑛,等.美国胃肠病学会2017版胶囊内镜临床指南解读[J].现代消化及介入诊疗,2017,22(4):614-617.
[12]Magalh2es-Costa P,Carmo J,Bispo M,et al.Superiority of the Split-dose PEG Regimen for Small-Bowel Capsule Endoscopy:ARandomized Controlled Trial[J].J ClinGastroentero,2016,50(7):e65.
[13]王洛伟,辛磊,林寒,等.中国消化内镜技术发展现状[J].中华消化内镜杂志,2015,32(8):501-515.
[14]方军,马丹,王树玲,等.肠道准备质量影响因素中患者相关因素的研究进展[J].中华消化内镜杂志,2016,33(4):265-267.
[15]Kashyap PK,Peled R.Polyethylene glycol plus an oral sulfate solution as a bowel cleansing regimen for colon capsule endoscopy:a prospective,single-arm study in healthy volunteers[J].Therap Adv Gastroenterol,2015,8(5):248-254.
[16]王海燕,李丽,王爱华,等.磷酸钠盐口服液与复方聚乙二醇电解质散在胶囊内镜检查前肠道清洁中效果的比较[J].现代消化及介入诊疗,2015,20(1):41-42.
[17]王宏霞,苏秉忠,胡海清,等.两种肠道准备方法在胶囊内镜检查中的效果对比[J].现代消化及介入诊疗,2015,20(5):541-543.
[18]Krijbolder MS,Grooteman KV,Bogers SK,et al.Addition of simethicone improves small bowel capsule endoscopy visualisationquality[J].Neth J Med,2018,76(1):27-31.
[19]张志宏,邱春华,李良平.比较西甲硅油不同使用方法在胶囊内镜肠道准备中的效果[J].中华消化内镜杂志,2016,33(7):473-475.
[20]Zhang S,Zheng D,Wang J,et al.Simethicone improves bowel cleansing with low-volume polyethylene glycol:a multicenter randomized trial[J].Endoscopy,2018,50(4):412-422.
[2]Singeap AM,Stanciu C,Trifan A.Capsule endoscopy:The road ahead[J].World J Gastroenterol,2016,22(1):369-378.
[3]赵莉,许乐,刚锐,等.复方聚乙二醇电解质散对老年患者肠道准备效果的随机对照研究[J].中华消化内镜杂志,2015,32(3):164-166.
[4]赵金芳,朱良如,任宏宇,等.三种口服复方聚乙二醇电解质散方案进行肠道准备的比较研究[J].中华消化内镜杂志,2015,32(9):613-616.
[5]Vuik FE,Schreuders EH,Wieten E,et al.Comparison of Polyethylene Glycol and Sulfate Solution as Cleansing Regimen for Colon Capsule Endoscopy[J].Gastrointest Endosc,2017,85(5):AB195-AB196.
[6]吴东,李骥,杨红,等.隔夜分次服用聚乙二醇联合西甲硅油提高上午结肠镜检查质量的价值研究[J].中华消化内镜杂志,2016,33(11):751-755.
[7]于兰,崔立红,付山峰,等.西甲硅油联合复方聚乙二醇电解质散在胶囊内镜肠道准备中的效果分析[J].中国新药杂志,2016,25(11):1271-1274.
[8]石蕾,尹一然,陈霞.三种中药导泻剂在结肠镜检查时肠道清洁效果的评价[J].四川中医,2015,33(12):104-105.
[9]蒋灵芝,桑华超,章春燕,等.持续口服西甲硅油对胶囊内镜图像质量的影响[J].中国全科医学,2015,18(15):1797-1799.
[10]顾宇,姚运河.胶囊内镜用于小肠疾病诊断的策略[J].国际消化病杂志,2016,36(6):340-342.
[11]黄骏盛,赖华生,农艳瑛,等.美国胃肠病学会2017版胶囊内镜临床指南解读[J].现代消化及介入诊疗,2017,22(4):614-617.
[12]Magalh2es-Costa P,Carmo J,Bispo M,et al.Superiority of the Split-dose PEG Regimen for Small-Bowel Capsule Endoscopy:ARandomized Controlled Trial[J].J ClinGastroentero,2016,50(7):e65.
[13]王洛伟,辛磊,林寒,等.中国消化内镜技术发展现状[J].中华消化内镜杂志,2015,32(8):501-515.
[14]方军,马丹,王树玲,等.肠道准备质量影响因素中患者相关因素的研究进展[J].中华消化内镜杂志,2016,33(4):265-267.
[15]Kashyap PK,Peled R.Polyethylene glycol plus an oral sulfate solution as a bowel cleansing regimen for colon capsule endoscopy:a prospective,single-arm study in healthy volunteers[J].Therap Adv Gastroenterol,2015,8(5):248-254.
[16]王海燕,李丽,王爱华,等.磷酸钠盐口服液与复方聚乙二醇电解质散在胶囊内镜检查前肠道清洁中效果的比较[J].现代消化及介入诊疗,2015,20(1):41-42.
[17]王宏霞,苏秉忠,胡海清,等.两种肠道准备方法在胶囊内镜检查中的效果对比[J].现代消化及介入诊疗,2015,20(5):541-543.
[18]Krijbolder MS,Grooteman KV,Bogers SK,et al.Addition of simethicone improves small bowel capsule endoscopy visualisationquality[J].Neth J Med,2018,76(1):27-31.
[19]张志宏,邱春华,李良平.比较西甲硅油不同使用方法在胶囊内镜肠道准备中的效果[J].中华消化内镜杂志,2016,33(7):473-475.
[20]Zhang S,Zheng D,Wang J,et al.Simethicone improves bowel cleansing with low-volume polyethylene glycol:a multicenter randomized trial[J].Endoscopy,2018,50(4):412-422.