日光-光动力疗法在光化性角化病治疗中的研究进展
摘要
局部光动力疗法(PDT)在非黑素瘤皮肤肿瘤的治疗中发挥重要作用,目前分为传统光动力疗法(c-PDT)和日光-光动力疗法(DL-PDT)。c-PDT主要用于Bowen病、浅表型和薄结节型基底细胞癌和光化性角化病(AK)的治疗。而DL-PDT是近年才研发的治疗方法,目前在欧美国家进行的临床研究较多,操作简单、疼痛轻微、患者依从性好,但易受到天气和光敏剂渗透的影响,关于DL-PDT的替代光源正在研发中。目前DL-PDT主要用于治疗较薄以及中等厚度的AK,尤其是多发性、大面积头面部AK的治疗。同时,DL-PDT还具有预防和(或)延缓AK产生,以及光子嫩肤作用。
引文
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[11]JALALKAMALI M,NEMATOLLAHI-MAHANI S N,SHOJAEI M,et al.Effect of light polarization on the efficiency of photodynamic therapy of basal cell carcinomas:an in vitro cellular study[J].Lasers Med Sci,2018,33(2):305-313.
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[16]FARGNOLI M C,IBBOTSON S H,HUNGER R E,et al.Patient and physician satisfaction in an observational study with methyl aminolevulinate daylight photodynamic therapy in the treatment of multiple actinic keratoses of the face and scalp in six European countries[J].J Eur Acad Dermatol Venereol,2018,32(5):757-762.
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[18]NEITTAANMAKI-PERTTU N,KARPPINEN T T,TANI T,et al.Long-term outcome of low-concentration hexyl-5-aminolaevulinate daylight photodynamic therapy for treatment of actinic keratoses[J].Acta Derm Venereol,2017,97(1):120-121.
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[20]OSMAN-PONCHET H,GABORIT A,SEVIN K,et al.Pretreatment of skin using an abrasive skin preparation pad,a microneedling device or iontophoresis improves absorption of methyl aminolevulinate in ex vivo human skin[J].Photodiagnosis Photodyn Ther,2017,20:130-136.
[21]CORDEY H,VALENTINE R,LESAR A,et al.Daylight photodynamic therapy in Scotland[J].Scott Med J,2017,62(2):48-53.
[22]JETTER N,CHANDAN N,WANG S,et al.Field cancerization therapies for management of actinic keratosis:a narrative review[J].Am J Clin Dermatol,2018,19(4):543-557.
[23]MORTON C A.A synthesis of the world's guidelines on photodynamic therapy for non-melanoma skin cancer[J].G Ital Dermatol Venereol,2018,153(6):783-792.
[24]MORTON C A,DOMINICUS R,RADNY P,et al.A randomized,multinational,noninferiority,phase III trial to evaluate the safety and efficacy of BF-200 aminolaevulinic acid gel vs.methyl aminolaevulinate cream in the treatment of nonaggressive basal cell carcinoma with photodynamic therapy[J].Br JDermatol,2018,179(2):309-319.
[25]TOMAS-VELAZQUEZ A,REDONDO P.Switching from conventional photodynamic therapy to daylight photodynamic therapy for actinic keratoses:systematic review and Meta-analysis[J].Actas Dermosifiliogr,2017,108(4):282-292.
[26]ZAAR O,SJOHOLM HYLEN A,GILLSTEDT M,et al.A prospective,randomized,within-subject study of ALA-PDT for actinic keratoses using different irradiation regimes[J].Photodermatol Photoimmunol Photomed,2018,34(5):338-342.
[27]SCHMITZ L,VON DOBBELER C,GUPTA G,et al.Photodynamic therapy leads to significant improvement of actinic keratosis area and severity index(AKASI)[J].Photodiagnosis Photodyn Ther,2018,21:66-70.
[28]FARGNOLI M C,PICCIONI A,NERI L,et al.Conventional vs.daylight methyl aminolevulinate photodynamic therapy for actinic keratosis of the face and scalp:an intra-patient,prospective,comparison study in Italy[J].J Eur Acad Dermatol Venereol,2015,29(10):1926-1932.
[29]HEPPT M V,STEEB T,NIESERT A C,et al.Local interventions for actinic keratosis in organ transplant recipients:a systematic review[J].Br J Dermatol,2019,180(1):43-50.
[30]TOGSVERD-BO K,HALLDIN C,SANDBERG C,et al.Photodynamic therapy is more effective than imiquimod for actinic keratosis in organ transplant recipients:a randomized intraindividual controlled trial[J].Br J Dermatol,2018,178(4):903-909.
[31]SOTIRIOU E,EVANGELOU G,PAPADAVID E,et al.Conventional vs.daylight photodynamic therapy for patients with actinic keratosis on face and scalp:12-month follow-up results of a randomized,intra-individual comparative analysis[J].J Eur Acad Dermatol Venereol,2018,32(4):595-600.
[32]MANLEY M,COLLINS P,GRAY L,et al.Quantifying the radiant exposure and effective dose in patients treated for actinic keratoses with topical photodynamic therapy using daylight and LED white light[J].Phys Med Biol,2018,63(3):035013.
[33]LERCHE C M,HEERFORDT I M,HEYDENREICH J,et al.Alternatives to outdoor daylight illumination for photodynamic therapy--use of greenhouses and artificial light sources[J].Int J Mol Sci,2016,17(3):309.
[34]MARRA K,LAROCHELLE E P,CHAPMAN M S,et al.comparison of blue and white lamp light with sunlight for daylightmediated,5-ALA photodynamic therapy,in vivo[J].Photochem Photobiol,2018,94(5):1049-1057.
[35]MORDON S,VIGNION-DEWALLE A S,THECUA E,et al.Can daylight-PDT be performed indoor?[J].G Ital Dermatol Venereol,2018,153(6):811-816.
[36]O'GORMAN S M,CLOWRY J,MANLEY M,et al.Artificial white light vs daylight photodynamic therapy for actinic keratoses:a randomized clinical trial[J].JAMA Dermatol,2016,152(6):638-644.
[2]KOHL E,KOLLER M,ZEMAN F,et al.Daylight photodynamic therapy versus cryosurgery for the treatment and prophylaxis of actinic keratoses of the face-protocol of a multicenter,prospective,randomized,controlled,two-armed study[J].BMC Dermatol,2017,17(1):12.
[3]SOTIRIOU E,APALLA Z,VRANI F,et al.Daylight photodynamic therapy vs.Conventional photodynamic therapy as skin cancer preventive treatment in patients with face and scalp cancerization:an intra-individual comparison study[J].J Eur Acad Dermatol Venereol,2017,31(8):1303-1307.
[4]IBBOTSON S,STONES R,BOWLING J,et al.A consensus on the use of daylight photodynamic therapy in the UK[J].JDermatolog Treat,2017,28(4):360-367.
[5]李庆贤,沈宝贤,种树彬,等.光动力与红、蓝光治疗面部痤疮的临床疗效[J].实用医学杂志,2016,32(16):2667-2670.
[6]MAHALINGAM S M,ORDAZ J D,LOW P S.Targeting of a photosensitizer to the mitochondrion enhances the potency of photodynamic therapy[J].ACS Omega,2018,3(6):6066-6074.
[7]GALVAO L E,GONCALVES H S,BOTELHO K P,et al.Daylight photodynamic therapy-experience and safety in treatment of actinic keratoses of the face and scalp in low latitude and high brightness region[J].An Bras Dermatol,2017,92(1):142-144.
[8]WANG B,SHI L,ZHANG Y F,et al.Gain with no pain?Pain management in dermatological photodynamic therapy[J].Br J Dermatol,2017,177(3):656-665.
[9]MORTON C A,BRAATHEN L R.Daylight photodynamic therapy for actinic keratoses[J].Am J Clin Dermatol,2018,19(5):647-656.
[10]WULF H C.The background and philosophy behind daylight photodynamic therapy[J].G Ital Dermatol Venereol,2018,153(6):776-782.
[11]JALALKAMALI M,NEMATOLLAHI-MAHANI S N,SHOJAEI M,et al.Effect of light polarization on the efficiency of photodynamic therapy of basal cell carcinomas:an in vitro cellular study[J].Lasers Med Sci,2018,33(2):305-313.
[12]FAI D,FAI C,CASSANO N,et al.Long-term follow-up assessment of daylight photodynamic therapy with methyl aminolevulinate in patients with actinic keratosis[J].G Ital Dermatol Venereol,2017,152(3):318-319.
[13]SEE J A,GEBAUER K,WU J K,et al.High patient satisfaction with daylight-activated methyl aminolevulinate cream in the treatment of multiple actinic keratoses:Results of an observational study in australia[J].Dermatol Ther(Heidelb),2017,7(4):525-533.
[14]CANTISANI C,PAOLINO G,SCARNO M,et al.Sequential methyl-aminolevulinate daylight photodynamic therapy and diclofenac plus hyaluronic acid gel treatment for multiple actinic keratosis evaluation[J].Dermatol Ther,2018,31(6):e12710.
[15]NISSEN C V,HEERFORDT I M,WIEGELL S R,et al.Pretreatment with 5-fluorouracil cream enhances the efficacy of daylight-mediated photodynamic therapy for actinic keratosis[J].Acta Derm Venereol,2017,97(5):617-621.
[16]FARGNOLI M C,IBBOTSON S H,HUNGER R E,et al.Patient and physician satisfaction in an observational study with methyl aminolevulinate daylight photodynamic therapy in the treatment of multiple actinic keratoses of the face and scalp in six European countries[J].J Eur Acad Dermatol Venereol,2018,32(5):757-762.
[17]REINHOLD U.A review of BF-200 ALA for the photodynamic treatment of mild-to-moderate actinic keratosis[J].Future Oncol,2017,13(27):2413-2428.
[18]NEITTAANMAKI-PERTTU N,KARPPINEN T T,TANI T,et al.Long-term outcome of low-concentration hexyl-5-aminolaevulinate daylight photodynamic therapy for treatment of actinic keratoses[J].Acta Derm Venereol,2017,97(1):120-121.
[19]OSMAN-PONCHET H,SEVIN K,GABORIT A,et al.Lack of effect of selected sunscreens applied on ex vivo human skin for 5-methyl-aminolevulinic acid penetration and protoporphyrin IXphotoactivation[J].Photodiagnosis Photodyn Ther,2017,17:75-81.
[20]OSMAN-PONCHET H,GABORIT A,SEVIN K,et al.Pretreatment of skin using an abrasive skin preparation pad,a microneedling device or iontophoresis improves absorption of methyl aminolevulinate in ex vivo human skin[J].Photodiagnosis Photodyn Ther,2017,20:130-136.
[21]CORDEY H,VALENTINE R,LESAR A,et al.Daylight photodynamic therapy in Scotland[J].Scott Med J,2017,62(2):48-53.
[22]JETTER N,CHANDAN N,WANG S,et al.Field cancerization therapies for management of actinic keratosis:a narrative review[J].Am J Clin Dermatol,2018,19(4):543-557.
[23]MORTON C A.A synthesis of the world's guidelines on photodynamic therapy for non-melanoma skin cancer[J].G Ital Dermatol Venereol,2018,153(6):783-792.
[24]MORTON C A,DOMINICUS R,RADNY P,et al.A randomized,multinational,noninferiority,phase III trial to evaluate the safety and efficacy of BF-200 aminolaevulinic acid gel vs.methyl aminolaevulinate cream in the treatment of nonaggressive basal cell carcinoma with photodynamic therapy[J].Br JDermatol,2018,179(2):309-319.
[25]TOMAS-VELAZQUEZ A,REDONDO P.Switching from conventional photodynamic therapy to daylight photodynamic therapy for actinic keratoses:systematic review and Meta-analysis[J].Actas Dermosifiliogr,2017,108(4):282-292.
[26]ZAAR O,SJOHOLM HYLEN A,GILLSTEDT M,et al.A prospective,randomized,within-subject study of ALA-PDT for actinic keratoses using different irradiation regimes[J].Photodermatol Photoimmunol Photomed,2018,34(5):338-342.
[27]SCHMITZ L,VON DOBBELER C,GUPTA G,et al.Photodynamic therapy leads to significant improvement of actinic keratosis area and severity index(AKASI)[J].Photodiagnosis Photodyn Ther,2018,21:66-70.
[28]FARGNOLI M C,PICCIONI A,NERI L,et al.Conventional vs.daylight methyl aminolevulinate photodynamic therapy for actinic keratosis of the face and scalp:an intra-patient,prospective,comparison study in Italy[J].J Eur Acad Dermatol Venereol,2015,29(10):1926-1932.
[29]HEPPT M V,STEEB T,NIESERT A C,et al.Local interventions for actinic keratosis in organ transplant recipients:a systematic review[J].Br J Dermatol,2019,180(1):43-50.
[30]TOGSVERD-BO K,HALLDIN C,SANDBERG C,et al.Photodynamic therapy is more effective than imiquimod for actinic keratosis in organ transplant recipients:a randomized intraindividual controlled trial[J].Br J Dermatol,2018,178(4):903-909.
[31]SOTIRIOU E,EVANGELOU G,PAPADAVID E,et al.Conventional vs.daylight photodynamic therapy for patients with actinic keratosis on face and scalp:12-month follow-up results of a randomized,intra-individual comparative analysis[J].J Eur Acad Dermatol Venereol,2018,32(4):595-600.
[32]MANLEY M,COLLINS P,GRAY L,et al.Quantifying the radiant exposure and effective dose in patients treated for actinic keratoses with topical photodynamic therapy using daylight and LED white light[J].Phys Med Biol,2018,63(3):035013.
[33]LERCHE C M,HEERFORDT I M,HEYDENREICH J,et al.Alternatives to outdoor daylight illumination for photodynamic therapy--use of greenhouses and artificial light sources[J].Int J Mol Sci,2016,17(3):309.
[34]MARRA K,LAROCHELLE E P,CHAPMAN M S,et al.comparison of blue and white lamp light with sunlight for daylightmediated,5-ALA photodynamic therapy,in vivo[J].Photochem Photobiol,2018,94(5):1049-1057.
[35]MORDON S,VIGNION-DEWALLE A S,THECUA E,et al.Can daylight-PDT be performed indoor?[J].G Ital Dermatol Venereol,2018,153(6):811-816.
[36]O'GORMAN S M,CLOWRY J,MANLEY M,et al.Artificial white light vs daylight photodynamic therapy for actinic keratoses:a randomized clinical trial[J].JAMA Dermatol,2016,152(6):638-644.