胃癌的中医证候及用药特点聚类分析
|
摘要
目的:探讨中医诊治胃癌的证候分型和用药特点。方法:收集整理2006年1月至2016年12月中国学术期刊全文数据库收录的相关中医诊治胃癌文献,建立辨证方药数据库和证型数据库,运用SPSS 18. 0统计软件对所选文献中的证型和方药进行频数分布分析和聚类分析,总结出胃癌的证候和证候群、辨证方药规律。结果:215篇文献共得证型79个,肝胃不和证频次明显高于其他证型,胃癌的实证总频次高于虚证。胃癌发病在胃,但与肝、脾关系极为密切。聚类分析形成6个聚类方,结果与中医的八纲辨证基本吻合。结论:胃癌的诊治应把握气机失调和痰食湿热毒为患的病理特征和以实为主、虚实夹杂的病机特点,做到在理、法、方、药上的整体把握和内在统一。
Objective: To explore the syndrome classification and medication characteristics of Chinese medicine in the diagnosis and treatment of gastric cancer. Methods: From January 2006 to December 2016,the relevant Chinese medicine diagnosis and treatment of gastric cancer literature collected in the full-text database of Chinese academic journals was collected and collated,and syndrome differentiation prescriptions and drugs databases and syndrome databases were established. The syndromes and prescriptions in the selected literature were analyzed using SPSS 18. 0 statistical software. Frequency distribution analysis and cluster analysis were carried out,and the syndromes,syndrome groups and syndrome differentiation of gastric cancer were summarized. Results: There were 79 syndromes in 215 literatures. The frequency of liver-stomach disharmony syndrome was significantly higher than that of other syndromes,and the total frequency of gastric cancer excess syndrome was higher than that of deficiency syndrome. Gastric cancer occured in the stomach,but it was closely related to the liver and spleen. Six clustering formulas were formed by cluster analysis,and the results basically coincided with the eight principles of syndrome differentiation in Chinese medicine.Conclusion: The diagnosis and treatment of gastric cancer should grasp the pathological characteristics of qi movement disorders and often Suffering from phlegm,food,dampness,heat and toxicity. We should also grasp its pathogenic characteristics of excess syndrome as the main factor,and the mixture of deficiency and excess,so as to achieve the overall grasp and internal unity in theory,methods,prescriptions and drugs.
Objective: To explore the syndrome classification and medication characteristics of Chinese medicine in the diagnosis and treatment of gastric cancer. Methods: From January 2006 to December 2016,the relevant Chinese medicine diagnosis and treatment of gastric cancer literature collected in the full-text database of Chinese academic journals was collected and collated,and syndrome differentiation prescriptions and drugs databases and syndrome databases were established. The syndromes and prescriptions in the selected literature were analyzed using SPSS 18. 0 statistical software. Frequency distribution analysis and cluster analysis were carried out,and the syndromes,syndrome groups and syndrome differentiation of gastric cancer were summarized. Results: There were 79 syndromes in 215 literatures. The frequency of liver-stomach disharmony syndrome was significantly higher than that of other syndromes,and the total frequency of gastric cancer excess syndrome was higher than that of deficiency syndrome. Gastric cancer occured in the stomach,but it was closely related to the liver and spleen. Six clustering formulas were formed by cluster analysis,and the results basically coincided with the eight principles of syndrome differentiation in Chinese medicine.Conclusion: The diagnosis and treatment of gastric cancer should grasp the pathological characteristics of qi movement disorders and often Suffering from phlegm,food,dampness,heat and toxicity. We should also grasp its pathogenic characteristics of excess syndrome as the main factor,and the mixture of deficiency and excess,so as to achieve the overall grasp and internal unity in theory,methods,prescriptions and drugs.
引文
[1]孙即舟,孙亚红,邵军.胃癌综合治疗进展[J].国外医学:肿瘤学分册,2005,32(8):621-623.
[2]刘庆,李忠,田劭丹,等. 167例进展期胃癌中医证型研究分析[J].北京中医药大学学报,2014,37(4):273-276.
[3]HOOTTAK,OYAMAT,AKAMATSUT,et al. A comparison of outcomes of endoscopic submucosal dissection(ESD)for early gastric neoplasms between high-volume and low-volume centers:multi-center retrospective questionnaire study conducted by the Nagano ESD Study Grope[J]. InterMed,2010,49(4):253-259.
[4]尹鹏,石彦,余佩武,等.腹腔镜与开腹胃癌D2根治术影响IL-6和IL-10表达的前瞻性研究[J].中华消化外科杂志,2013,12(5):358-361.
[5]孙燕,石远凯.临床肿瘤内科手册[M]. 5版.北京:人民卫生出版社,2007:476-477.
[6]邬伟,张璐,舒琦瑾.胃癌中医证型构成及分布规律的文献分析[J].中华中医药学刊,2014,32(1):173-175.
[7]伍安银,周玉,姚德蛟.参苓白术散治疗肿瘤的综述[J].陕西中医学院学报,2015,38(1):93-95.
[8]楼金杰,谢长生.胃癌中医证型的现代研究进展[J].陕西中医药大学学报,2016,39(2):107-110
[9]李东芳,王云启,周珉.中西医结合治疗中晚期胃癌的临床观察[J].四川中医杂志,2012,11(30):88-89.
[10]李东芳,焦蕉,胡亚,等.应用聚类分析探讨胃癌术后中医证型分布规律的临床研究[J].湖南中医药大学学报,2016,36(9):90-97.
[11]高学敏.中药学[M].北京:中国中医药出版社,2007.
[12]邓中甲.方剂学[M].北京:中国中医药出版社,2003.
[13]朱文峰.中医诊断学[M].北京:中国中医药出版社,2002:158-215.
[14]司富春,岳静宇.食管鳞癌的中医证候聚类分析[J].中医杂志,2012,53(22):1944-1947.
[15]王雪华,夏春明,颜建军,等.中医证候分类中常用的多元统计分析方法及应用评析[J].世界科学技术—中医药现代化,2008,10(12):15-20.
[2]刘庆,李忠,田劭丹,等. 167例进展期胃癌中医证型研究分析[J].北京中医药大学学报,2014,37(4):273-276.
[3]HOOTTAK,OYAMAT,AKAMATSUT,et al. A comparison of outcomes of endoscopic submucosal dissection(ESD)for early gastric neoplasms between high-volume and low-volume centers:multi-center retrospective questionnaire study conducted by the Nagano ESD Study Grope[J]. InterMed,2010,49(4):253-259.
[4]尹鹏,石彦,余佩武,等.腹腔镜与开腹胃癌D2根治术影响IL-6和IL-10表达的前瞻性研究[J].中华消化外科杂志,2013,12(5):358-361.
[5]孙燕,石远凯.临床肿瘤内科手册[M]. 5版.北京:人民卫生出版社,2007:476-477.
[6]邬伟,张璐,舒琦瑾.胃癌中医证型构成及分布规律的文献分析[J].中华中医药学刊,2014,32(1):173-175.
[7]伍安银,周玉,姚德蛟.参苓白术散治疗肿瘤的综述[J].陕西中医学院学报,2015,38(1):93-95.
[8]楼金杰,谢长生.胃癌中医证型的现代研究进展[J].陕西中医药大学学报,2016,39(2):107-110
[9]李东芳,王云启,周珉.中西医结合治疗中晚期胃癌的临床观察[J].四川中医杂志,2012,11(30):88-89.
[10]李东芳,焦蕉,胡亚,等.应用聚类分析探讨胃癌术后中医证型分布规律的临床研究[J].湖南中医药大学学报,2016,36(9):90-97.
[11]高学敏.中药学[M].北京:中国中医药出版社,2007.
[12]邓中甲.方剂学[M].北京:中国中医药出版社,2003.
[13]朱文峰.中医诊断学[M].北京:中国中医药出版社,2002:158-215.
[14]司富春,岳静宇.食管鳞癌的中医证候聚类分析[J].中医杂志,2012,53(22):1944-1947.
[15]王雪华,夏春明,颜建军,等.中医证候分类中常用的多元统计分析方法及应用评析[J].世界科学技术—中医药现代化,2008,10(12):15-20.