中药寒热药性与线粒体能量代谢关系研究
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摘要
中药具有寒,热之性,寒热药性是从药物的作用性质上对药物多种医疗作用的高度概括,是中药药性理论的核心内容。总结和反思寒热药性研究的前期成果发现,中医的寒证、热证与机体能量代谢的关系密切,寒热中药可能通过影响能量代谢的某些环节,实现对寒热证的调节。线粒体是细胞氧化供能的重要部位,线粒体中的关键酶、解偶联蛋白以及三羧酸循环节点代谢产物等在调控能量代谢方面发挥重要作用。基于线粒体能量代谢的中药寒热药性研究为揭示药性的本质研究提供了一个新的思路。
Traditional Chinese medicine(TCM) has the nature of cold and hot.Cold and hot properties are highly summarized that are from the nature of drug on a wide range of medical role,which is the core content of the theory of Chinese medicine properties.Summary and reflection of cold and hot properties that are from preliminary results show that it is closely related to the body's energy metabolism.Chills and fever Chinese medicine may affect some links of energy metabolism,achieve the regulation of symptoms caused by cold and hot factors.Mitochondria is the essential part of cellular oxidative and energy supply,key enzyme,uncoupling protein,and citric acid cycle node metabolites in mitochondria play an important role in the regulation of energy metabolism.Study of cold and hot properties based on mitochondrial energy metabolism provides a new way of thinking for revealing the herbal essence.
Traditional Chinese medicine(TCM) has the nature of cold and hot.Cold and hot properties are highly summarized that are from the nature of drug on a wide range of medical role,which is the core content of the theory of Chinese medicine properties.Summary and reflection of cold and hot properties that are from preliminary results show that it is closely related to the body's energy metabolism.Chills and fever Chinese medicine may affect some links of energy metabolism,achieve the regulation of symptoms caused by cold and hot factors.Mitochondria is the essential part of cellular oxidative and energy supply,key enzyme,uncoupling protein,and citric acid cycle node metabolites in mitochondria play an important role in the regulation of energy metabolism.Study of cold and hot properties based on mitochondrial energy metabolism provides a new way of thinking for revealing the herbal essence.
引文
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[12]吴云起,唐汉庆,吴翠松,等.脾阳虚证大鼠棕色脂肪组织和解偶联蛋白1关联性的研究[J].中国实验方剂学杂志,2011,17(14):206-210.
[13]匡海学,王艳宏.基于中药性味可拆分性和可组合性的中药性味理论研究新模式[J].世界科学技术-中医现代化,2011,13(1):25-29.
[14]Kuang HX,Wang YY.Metabonomics research of the four propertiesin traditional Chinese medicine based on UPLC-QTOF-MS system[J].Chinese Medicine,2011,11:13-28.
[2]Sudar E,Velebit J,Gluvic Z,et al.Hypothetical mechanism of sodi-um pump regulation by estradiol under primary hypertension[J].JTheor Biol,2008,251(4):584-592.
[3]高小恒,陈达艳,周俊.中药四性能量代谢方法研究概述[J].实用中医药杂志,2011,27(7):496-497.
[4]黄丽萍,彭淑红,胡强,等.6味热性中药对大鼠骨骼肌能量代谢相关因子的影响[J].中华中医药杂志,2010,25(2):228-230.
[5]黄丽萍,彭淑红,蒙晓芳,等.6种寒性中药对大鼠肝脏能量代谢的影响[J].中国中药杂志,2009,34(24):3255-3258.
[6]于华芸,季旭明,吴智春,等.附子对大鼠能量代谢及相关基因表达的影响[J].中国中药杂志,2011,36(18):2535-2538.
[7]陈保华,黄荣,车河龙,等.汉防己甲素不同给药方式对大鼠供肝能量代谢的影响[J].中国医院用药评价与分析,2011,11(8):717-718.
[8]林丽娜,王万铁,徐正阶.体外循环下心肌缺血再灌注损伤川芎嗪的保护最作用[J].温州医学院学报,1997,27(1):20-23.
[9]孙常义,裴海泓,孙晓春,等.党参对训练后人体血细胞及小鼠心肌作用的定量细胞化学研究[J].体育科学,1999,19(5):33-34.
[10]Clarkea KJ,Adamsa AE.A role for ubiquitinylation and the cytosolicproteasome in turnover of mitochondrial uncoupling protein 1(UCP1)[J].Biochim Biophys Acta,2012,1817:1759-1767.
[11]Diano S,Horvath TL.Mitochondrial uncoupling protein 2(UCP2)in glucose and lipid metabolism[J].Trends Mol Med,2012,18(1):52-58.
[12]吴云起,唐汉庆,吴翠松,等.脾阳虚证大鼠棕色脂肪组织和解偶联蛋白1关联性的研究[J].中国实验方剂学杂志,2011,17(14):206-210.
[13]匡海学,王艳宏.基于中药性味可拆分性和可组合性的中药性味理论研究新模式[J].世界科学技术-中医现代化,2011,13(1):25-29.
[14]Kuang HX,Wang YY.Metabonomics research of the four propertiesin traditional Chinese medicine based on UPLC-QTOF-MS system[J].Chinese Medicine,2011,11:13-28.