影响儿童哮喘气道高反应的危险因素分析
|
摘要
目的探究影响儿童哮喘气道高反应的危险因素。方法回顾性分析2016年10月—2017年10月收治的82例疑似哮喘患儿的临床资料。所有患儿均接受支气管激发试验,根据结果分为观察组(气道反应增高) 35例和对照组(气道反应正常) 47例。对影响儿童哮喘气道高反应发生的相关因素进行非条件Logistic多元回归分析。结果病程> 1. 5年、喘息、过敏性鼻炎、小气道功能异常、哮喘家族史、吸入过敏原、呼吸道感染是影响儿童哮喘气道高反应的独立危险因素(P <0. 05)。结论临床上应重视上述影响儿童哮喘气道高反应的独立危险因素,并采取适当的预防干预措施。
Objective To study risk factors affecting airway hyperresponsiveness in childhood asthma. Methods Clinical data of 82 children with suspected asthma admitted during October 2016 and October 2017 was retrospectively analyzed. All patients received bronchial provocation test,and then the patients were divided into observation group(increasing airway response,n = 35) and control group(normal airway response,n = 47) according to test results. Related factors affecting occurrence of airway hyperresponsiveness in childhood asthma were analyzed by non-condition Logistic multivariate regression analysis. Results Course of disease more than 1. 5 years,gasping,allergic rhinitis,small airway dysfunction,family history of asthma,inhalation allergens and respiratory infections were independent risk factors affecting airway hyperresponsiveness in childhood asthma(P < 0. 05). Conclusion Independent risk factors affecting airway hyperresponsiveness in children with asthma should be paid more attention,and appropriate preventive measures should be taken.
Objective To study risk factors affecting airway hyperresponsiveness in childhood asthma. Methods Clinical data of 82 children with suspected asthma admitted during October 2016 and October 2017 was retrospectively analyzed. All patients received bronchial provocation test,and then the patients were divided into observation group(increasing airway response,n = 35) and control group(normal airway response,n = 47) according to test results. Related factors affecting occurrence of airway hyperresponsiveness in childhood asthma were analyzed by non-condition Logistic multivariate regression analysis. Results Course of disease more than 1. 5 years,gasping,allergic rhinitis,small airway dysfunction,family history of asthma,inhalation allergens and respiratory infections were independent risk factors affecting airway hyperresponsiveness in childhood asthma(P < 0. 05). Conclusion Independent risk factors affecting airway hyperresponsiveness in children with asthma should be paid more attention,and appropriate preventive measures should be taken.
引文
[1]王晨,刘玉英,邹玮,等.不同年龄段喘息或哮喘急性发作患儿的对比研究[J].西部医学,2017,29(5):652-655,661.
[2]莫丽慧,钟丽花.孟鲁司特联合布地奈德治疗支气管哮喘患儿的临床观察[J].中国药房,2017,28(14):1981-1984.
[3]陈江,任翼,何娜,等.维生素D3的补充对儿童哮喘控制的随机对照研究[J].重庆医学,2017,46(32):4505-4507,4510.
[4]曾泽宇,孔璐丹,张维溪,等.雷公藤红素对肥胖型哮喘气道高反应的影响[J].医学研究杂志,2017,46(4):28-31.
[5]王林燕,王博,丁美红,等.气道高反应性检测方法的研究进展[J].广东医学,2017,38(11):1774-1778.
[6]方丽萍,陈敏,张方,等.解整合素-金属蛋白酶33在不同严重程度哮喘患者血清中的表达水平及其与气道慢性炎症的关系[J].医学研究生学报,2017,30(5):521-524.
[7]杨哲,宋欣,李硕,等.支气管哮喘控制患儿小气道功能状况及影响因素分析[J].中华实用儿科临床杂志,2017,32(16):1244-1247.
[8]曾靖,胡琦,钟世民,等.学龄前儿童呼出一氧化氮及气道高反应性与哮喘控制的相关性研究[J].重庆医学,2017,46(25):3529-3531,3535.
[9]姜朕,李卫华,朱峰,等. 5岁以下喘息患儿哮喘预测指数与外周血单核细胞TLR4表达的相关性研究[J].重庆医学,2017,46(8):1012-1014.
[10]沈仁,李孟荣,张林桃,等.哮喘预测指数与婴幼儿首次毛细支气管炎及以后反复喘息的相关性观察[J].中国儿童保健杂志,2017,25(3):293-296.
[11]王玲,胡雅琳,杨蕊铭,等.过敏性鼻炎合并哮喘患者血液嗜酸性粒细胞富集群中IL-18、IL-18BP及IL-18R的表达[J].郑州大学学报:医学版,2017,52(5):598-602.
[12]陈希,郭梓君,郑佩燕,等.哮喘并过敏性鼻炎儿童血清总Ig E、外周血嗜酸性粒细胞、过敏原致敏程度与呼出气一氧化氮间的关系[J].实用医学杂志,2017,33(15):2501-2505.
[13]邓玫.黄芪颗粒治疗过敏性鼻炎哮喘综合征患儿的疗效及对血清Th1、Th2细胞因子的影响[J].中医药学报,2017,45(2):68-71.
[14]黄彩虹,闫凡.缓解期哮喘患儿的小气道功能和气道高反应性的相关性研究[J].临床肺科杂志,2017,22(6):1067-1070.
[15]沈立新,赵福良,夏振炜.哮喘缓解期患儿小气道功能的监测及临床意义[J].西部医学,2017,29(9):1225-1228.
[16]刘清华,田美莲.急性哮喘并发肺部感染患儿病原菌的构成及其危险因素分析[J].中国妇幼保健,2017,32(17):4180-4182.
[17]金世杰,饶花平,罗力妍,等.影响儿童支气管哮喘发病的危险因素研究[J].中国医师杂志,2017,19(12):1898-1900.
[18]梁意敏,古奕文,马远平.小儿支气管哮喘急性发作的相关影响因素研究[J].临床肺科杂志,2017,22(4):673-675.
[19]刘树俊,王婷婷,曹世钰,等.中国儿童哮喘危险因素的Meta分析[J].中国当代儿科杂志,2018,20(3):218-223.
[20]臧艳艳,柴文戍,王君灵,等.过敏性鼻炎合并哮喘患者血液嗜酸性粒细胞群中P物质及其受体表达上调[J].西安交通大学学报:医学版,2018,39(2):250-255.
[21]康娟.支气管哮喘患者的相关危险因素分析及其心理健康状况[J].临床肺科杂志,2017,22(8):1468-1470.
[2]莫丽慧,钟丽花.孟鲁司特联合布地奈德治疗支气管哮喘患儿的临床观察[J].中国药房,2017,28(14):1981-1984.
[3]陈江,任翼,何娜,等.维生素D3的补充对儿童哮喘控制的随机对照研究[J].重庆医学,2017,46(32):4505-4507,4510.
[4]曾泽宇,孔璐丹,张维溪,等.雷公藤红素对肥胖型哮喘气道高反应的影响[J].医学研究杂志,2017,46(4):28-31.
[5]王林燕,王博,丁美红,等.气道高反应性检测方法的研究进展[J].广东医学,2017,38(11):1774-1778.
[6]方丽萍,陈敏,张方,等.解整合素-金属蛋白酶33在不同严重程度哮喘患者血清中的表达水平及其与气道慢性炎症的关系[J].医学研究生学报,2017,30(5):521-524.
[7]杨哲,宋欣,李硕,等.支气管哮喘控制患儿小气道功能状况及影响因素分析[J].中华实用儿科临床杂志,2017,32(16):1244-1247.
[8]曾靖,胡琦,钟世民,等.学龄前儿童呼出一氧化氮及气道高反应性与哮喘控制的相关性研究[J].重庆医学,2017,46(25):3529-3531,3535.
[9]姜朕,李卫华,朱峰,等. 5岁以下喘息患儿哮喘预测指数与外周血单核细胞TLR4表达的相关性研究[J].重庆医学,2017,46(8):1012-1014.
[10]沈仁,李孟荣,张林桃,等.哮喘预测指数与婴幼儿首次毛细支气管炎及以后反复喘息的相关性观察[J].中国儿童保健杂志,2017,25(3):293-296.
[11]王玲,胡雅琳,杨蕊铭,等.过敏性鼻炎合并哮喘患者血液嗜酸性粒细胞富集群中IL-18、IL-18BP及IL-18R的表达[J].郑州大学学报:医学版,2017,52(5):598-602.
[12]陈希,郭梓君,郑佩燕,等.哮喘并过敏性鼻炎儿童血清总Ig E、外周血嗜酸性粒细胞、过敏原致敏程度与呼出气一氧化氮间的关系[J].实用医学杂志,2017,33(15):2501-2505.
[13]邓玫.黄芪颗粒治疗过敏性鼻炎哮喘综合征患儿的疗效及对血清Th1、Th2细胞因子的影响[J].中医药学报,2017,45(2):68-71.
[14]黄彩虹,闫凡.缓解期哮喘患儿的小气道功能和气道高反应性的相关性研究[J].临床肺科杂志,2017,22(6):1067-1070.
[15]沈立新,赵福良,夏振炜.哮喘缓解期患儿小气道功能的监测及临床意义[J].西部医学,2017,29(9):1225-1228.
[16]刘清华,田美莲.急性哮喘并发肺部感染患儿病原菌的构成及其危险因素分析[J].中国妇幼保健,2017,32(17):4180-4182.
[17]金世杰,饶花平,罗力妍,等.影响儿童支气管哮喘发病的危险因素研究[J].中国医师杂志,2017,19(12):1898-1900.
[18]梁意敏,古奕文,马远平.小儿支气管哮喘急性发作的相关影响因素研究[J].临床肺科杂志,2017,22(4):673-675.
[19]刘树俊,王婷婷,曹世钰,等.中国儿童哮喘危险因素的Meta分析[J].中国当代儿科杂志,2018,20(3):218-223.
[20]臧艳艳,柴文戍,王君灵,等.过敏性鼻炎合并哮喘患者血液嗜酸性粒细胞群中P物质及其受体表达上调[J].西安交通大学学报:医学版,2018,39(2):250-255.
[21]康娟.支气管哮喘患者的相关危险因素分析及其心理健康状况[J].临床肺科杂志,2017,22(8):1468-1470.