摘要
目的通过报道1例保守治疗神经源性骨化性肌炎(neurogenic myositis ossificans, NMO)及文献复习,提高对NMO的认识,同时为临床应用该方法治疗NMO提供参考。方法 1例NMO病人行保守治疗,通过治疗后病人症状变化来评估治疗效果,应用影像学资料评估病灶是否继续增大。同时复习相关文献,总结该病的发病、诊断、治疗及预防。结果保守治疗后病人病情得到控制,且复查X线及CT明确病灶较前未见明显增大、边界较前更清楚、骨小梁较前更明显。结论保守治疗可以改善NMO病人的症状、控制病灶进一步增大,但仍需大量高质量、高循证等级研究来提供足够的证据。
引文
[1]Sakellariou VI,Grigoriou E,Mavrogenis AF,et al.Heterotopic ossification following traumatic brain injury and spinal cord injury:insight into the etiology and pathophysiology[J].J Musculoskelet Neuronal Interact,2012,12(4):230-240.
[2]van Kuijk AA,Geurts AC,van Kuppevelt HJ.Neurogenic heterotopic ossification in spinal cord injury[J].Spinal Cord,2002,40(7):313-326.
[3]Carlier RY,Safa DM,Parva P,et al.Ankylosing neurogenic myositis ossificans of the hip.An enhanced volumetric CT study[J].JBone Joint Surg Br,2005,87(3):301-305.
[4]刘倩倩,孟宪忠,庄燕,等.神经源性骨化性肌炎1例临床报告[J].中风与神经疾病杂志,2018,35(5):469-471.
[5]Vanden Bossche L,Vanderstraeten G.Heterotopic ossification:a review[J].J Rehabil Med,2005,37(3):129-136.
[6]Wu XB,Yang MH,Zhu SW,et al.Surgical resection of severe heterotopic ossification after open reduction and internal fixation of acetabular fractures:a case series of 18 patients[J].Injury,2014,45(10):1604-1610.
[7]Wick L,Berger M,Knecht H,et al.Magnetic resonance signal alterations in the acute onset of heterotopic ossification in patients with spinal cord injury[J].Eur Radiol,2005,15(9):1867-1875.
[8]Gautschi OP,Toffoli AM,Joesbury KA,et al.Osteoinductive effect of cerebrospinal fluid from brain-injured patients[J].J Neurotrauma,2007,24(1):154-162.
[9]Kantak AP,Shah NN.Extensive surgical wound lavage reduces the incidence and severity of heterotopic ossification in primary total hip replacement:a study of 175 hip replacements[J].Hip Pelvis,2017,29(4):234-239.
[10]Hata K,Takahata Y,Murakami T,et al.Transcriptional network controlling endochondral ossification[J].J Bone Metab,2017,24(2):75-82.
[11]Wang L,Tang X,Zhang H,et al.Elevated leptin expression in rat model of traumatic spinal cord injury and femoral fracture[J].JSpinal Cord Med,2011,34(5):501-509.
[12]Mitchell EJ,Canter J,Norris P,et al.The genetics of heterotopic ossification:insight into the bone remodeling pathway[J].J Orthop Trauma,2010,24(9):530-533.
[13]劳群,章士正.骨化性肌炎的发病机制、病程与影像学的关系[J].浙江医学,2007,29(3):294-295.
[14]金玉梅,王叶武,李艳丽.局限性骨化性肌炎CT、MRI表现与相应病理分析[J].实用医学杂志,2016,32(24):4073-4076.
[15]Jiang Q,Chen MJ,Yang C,et al.Post-infectious myositis ossificans in medial-lateral pterygoid muscles:a case report and review of the literature[J].Oncol Lett,2015,9(2):920-926.
[16]Banovac K,Williams JM,Patrick LD,et al.Prevention of heterotopic ossification after spinal cord injury with COX-2 selective inhibitor(rofecoxib)[J].Spinal Cord,2004,42(12):707-710.
[17]Banovac K,Williams JM,Patrick LD,et al.Prevention of heterotopic ossification after spinal cord injury with indomethacin[J].Spinal Cord,2001,39(7):370-374.
[18]Zhang X,Schwarz EM,Young DA,et al.Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblasts lineage and is critically involved in bone repair[J].J Clin Invest,2002,109(11):1405-1415.
[19]Genet F,Marmorat JL,Lautridou C,et al.Impact of late surgical intervention on heterotopic ossification of the hip after traumatic neurological injury[J].J Bone Joint Surg Br,2009,91(11):1493-1498.
[20]Campbell TM,Reilly K,Laneuville O,et al.Bone replaces articular cartilage in the rat knee joint after prolonged immobilization[J].Bone,2018,106:42-51.
[21]Law-Ye B,Hangard C,Felter A,et al.Pre-surgical CT-assessment of neurogenic myositis ossificans of the hip and risk factors of recurrence:a series of 101 consecutive patients[J].BMC Musculoskelet Disord,2016,17(1):433.
[22]Denormandie P,de l.Escalopier N,Gatin L,et al.Resection of neurogenic heterotopic ossification(NHO)of the hip[J].Orthop Traumatol Surg Res,2018,104(1S):S121-S127.
[23]Yoon BH,Park IK,Sung YB.Ankylosing neurogenic myositis ossificans of the hip:a case series and review of literature[J].Hip Pelvis,2018,30(2):86-91.
[24]Baird EO,Kang QK.Prophylaxis of heterotopic ossification-an updated review[J].J Orthop Surg Res,2009,4:12.(收稿日期:2018-12-27)