前列活血通络汤联合八正散治疗慢性非细菌性前列腺炎
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摘要
目的探讨自拟前列活血通络汤联合八正散对慢性非细菌性前列腺炎患者疗效及炎症因子的影响。方法选择2015年2月-2016年1月在本院确诊治疗的慢性非细菌性前列腺炎患者70例,以随机数字表法分为对照组与治疗组,各35例。对照组予前列通瘀胶囊,治疗组在此基础上予自拟前列活血通络汤联合八正散。观察比较2组临床疗效、NIH-CPSI及中医证候评分改善情况,以及其对炎症因子的影响。结果观察组总有效率91.43%,优于对照组的68.57%(P <0.05);观察组治疗后患者的IL-6、IL-8、IL-10和TNF-α水平均显著低于治疗前(P <0.05),且优于对照组(P <0.05);观察组治疗后NIH-CPSI和中医证候评分分别为(14.21±4.15)分和(5.36±1.27)分,优于对照组的(18.53±5.22)分和(6.08±1.49)分(P <0.05)。结论自拟前列活血通络汤联合八正散治疗慢性非细菌性前列腺炎,可降低炎症因子水平,改善患者的免疫异常状况,提高生活质量。
Objective To study the influence of curative effect andinflammatory factors by Qianlie Huoxue Tongluo decoction combined with Bazheng powder on chronic patients with nonbacterial prostatitis. Methods 70 cases who were diagnosed as chronic patients with nonbacterial patients from February 2015 to January 2016 were researched, they were randomly divided into two groups, the control group was treated with Qianlie Tongyu capsule,the treatment group was given Qianlie Huoxue Tongluo decoction combined with Bazheng powder. Observed and compared the therapeutic effect of the two groups, analyzed the expression of inflammatory factors in patients, and compared the two groups of NIH-CPSI and traditional Chinese medicine syndrome score. Results The total effective rate of observation group was 91.43%, which was better than 68.57% of the control group(P <0.05). The levels of IL-6, IL-8, IL-10 and TNF-α in the observation group after treatment were significantly lower than those before treatment(P<0.05), and they were better than those in the control group(P<0.05). After treatment, the scores of NIH-CPSI and TCM syndrome in the observation group were(14.21 ±4.15) and(5.36±1.27), respectively, which were better than those in the control group(18.53 ±5.22 and 6.08 ±1.49, P <0.05). Conclusion Qianlie Huoxue Tongluo decoction combined with Bazheng powder are effective in the treatment of chronic nonbacterial prostatitis patients, which can significantly reduce the expression of inflammatory factor, improve the immune abnormality of patients and the quality of life.
Objective To study the influence of curative effect andinflammatory factors by Qianlie Huoxue Tongluo decoction combined with Bazheng powder on chronic patients with nonbacterial prostatitis. Methods 70 cases who were diagnosed as chronic patients with nonbacterial patients from February 2015 to January 2016 were researched, they were randomly divided into two groups, the control group was treated with Qianlie Tongyu capsule,the treatment group was given Qianlie Huoxue Tongluo decoction combined with Bazheng powder. Observed and compared the therapeutic effect of the two groups, analyzed the expression of inflammatory factors in patients, and compared the two groups of NIH-CPSI and traditional Chinese medicine syndrome score. Results The total effective rate of observation group was 91.43%, which was better than 68.57% of the control group(P <0.05). The levels of IL-6, IL-8, IL-10 and TNF-α in the observation group after treatment were significantly lower than those before treatment(P<0.05), and they were better than those in the control group(P<0.05). After treatment, the scores of NIH-CPSI and TCM syndrome in the observation group were(14.21 ±4.15) and(5.36±1.27), respectively, which were better than those in the control group(18.53 ±5.22 and 6.08 ±1.49, P <0.05). Conclusion Qianlie Huoxue Tongluo decoction combined with Bazheng powder are effective in the treatment of chronic nonbacterial prostatitis patients, which can significantly reduce the expression of inflammatory factor, improve the immune abnormality of patients and the quality of life.
引文
[1]陈胜辉,姚文亮.针刺配合热敏灸治疗慢性非细菌性前列腺炎的临床疗效[J].中国老年学杂志,2015,35(22):6510-6512.
[2]邱亚娟,龙建军,陈元平,等.运动锻炼对老年慢性非细菌性前列腺炎患者的辅助康复效果[J].中国老年学杂志,2015,20(18):5220-5221.
[3]曾定胜,何跃,肖艳红,等.前列舒通胶囊联合盐酸坦索罗辛胶囊对慢性非细菌性前列腺炎炎症因子水平的影响及其临床疗效[J].国际泌尿系统杂志,2017,37(6):865-869..
[4]VITTORIO MAGRI,EMANUELE MONTANARI,VI?NJA?KERK.Fluoroquinolone-macrolide combination therapy for chronic bacterialprostatitis:retrospective analysis of pathogen eradication rates,inflammatory findings and sexual dysfunction[J].Asian J Androl.2011 November;13(6):819-827.
[5]李亚萍.八正散加减方治疗泌尿系感染48例[J].陕西中医,2012,33(12):1591-1593.
[6]ENZO VICARI,SANDRO L A VIGNERA,DOMENICOARCORIA.High Frequency of Chronic Bacterial and NonInflammatory Prostatitisin Infertile Patients with Prostatitis Syndrome Plus Irritable Bowel Syndrome[J].PLoS One,2011,6(4):e18647.
[7]刘永安,陈晓丽,徐泽彪,等.前列腺汤联合莫西沙星治疗慢性细菌性前列腺炎临床研究[J].吉林中医药,2013,33(9):911-912.
[8]赵文硕,张青,杨霖,等.八正散加味预防注射用盐酸吡柔比星膀胱灌注不良反应临床观察[J].中国中医药信息杂志,2013,25(10):70-71.
[9]李永伟,王春霞,何志强,等.TNF-α、TGF-β1在慢性非细菌性前列腺炎病人前列腺液中的表达水平及意义[J].中国老年学杂志,2013,33(14):3409-3410.
[10]韩桂香,牛培宁,曾庆琪,等.论肝郁气滞在慢性前列腺炎发病及病程中的意义[J].吉林中医药,2015,35(1):13-15.
[11]尤耀东,黄晓朋,陈晓洋,等.基于腺性膀胱炎模型大鼠探讨八正散对IL-6、IL-17、TGF-β1表达的影响[J].中国男科学杂志,2015,18(12):26-31.
[12]袁晶,聂雪峰,车光龙,等.活血通络、疏肝理气、扶正固本汤治疗老年PHN的疗效观察[J].西南国防医药,2015,25(5):540-541.
[13]张伟,程运中,宋哲伟,等.针灸治疗慢性前列腺炎[J].吉林中医药,2016,36(6):629-632.
[14]赵钢,高原,于文慧,等.活血通络汤治疗下肢动脉硬化闭塞症60例[J].中国中西医结合外科杂志,2015,24(3):286-287.
[2]邱亚娟,龙建军,陈元平,等.运动锻炼对老年慢性非细菌性前列腺炎患者的辅助康复效果[J].中国老年学杂志,2015,20(18):5220-5221.
[3]曾定胜,何跃,肖艳红,等.前列舒通胶囊联合盐酸坦索罗辛胶囊对慢性非细菌性前列腺炎炎症因子水平的影响及其临床疗效[J].国际泌尿系统杂志,2017,37(6):865-869..
[4]VITTORIO MAGRI,EMANUELE MONTANARI,VI?NJA?KERK.Fluoroquinolone-macrolide combination therapy for chronic bacterialprostatitis:retrospective analysis of pathogen eradication rates,inflammatory findings and sexual dysfunction[J].Asian J Androl.2011 November;13(6):819-827.
[5]李亚萍.八正散加减方治疗泌尿系感染48例[J].陕西中医,2012,33(12):1591-1593.
[6]ENZO VICARI,SANDRO L A VIGNERA,DOMENICOARCORIA.High Frequency of Chronic Bacterial and NonInflammatory Prostatitisin Infertile Patients with Prostatitis Syndrome Plus Irritable Bowel Syndrome[J].PLoS One,2011,6(4):e18647.
[7]刘永安,陈晓丽,徐泽彪,等.前列腺汤联合莫西沙星治疗慢性细菌性前列腺炎临床研究[J].吉林中医药,2013,33(9):911-912.
[8]赵文硕,张青,杨霖,等.八正散加味预防注射用盐酸吡柔比星膀胱灌注不良反应临床观察[J].中国中医药信息杂志,2013,25(10):70-71.
[9]李永伟,王春霞,何志强,等.TNF-α、TGF-β1在慢性非细菌性前列腺炎病人前列腺液中的表达水平及意义[J].中国老年学杂志,2013,33(14):3409-3410.
[10]韩桂香,牛培宁,曾庆琪,等.论肝郁气滞在慢性前列腺炎发病及病程中的意义[J].吉林中医药,2015,35(1):13-15.
[11]尤耀东,黄晓朋,陈晓洋,等.基于腺性膀胱炎模型大鼠探讨八正散对IL-6、IL-17、TGF-β1表达的影响[J].中国男科学杂志,2015,18(12):26-31.
[12]袁晶,聂雪峰,车光龙,等.活血通络、疏肝理气、扶正固本汤治疗老年PHN的疗效观察[J].西南国防医药,2015,25(5):540-541.
[13]张伟,程运中,宋哲伟,等.针灸治疗慢性前列腺炎[J].吉林中医药,2016,36(6):629-632.
[14]赵钢,高原,于文慧,等.活血通络汤治疗下肢动脉硬化闭塞症60例[J].中国中西医结合外科杂志,2015,24(3):286-287.