参苓白术散加减方对结直肠癌患者术后化疗免疫功能影响
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摘要
目的:探讨参苓白术散加减方对结直肠术后化疗患者免疫功能的影响。方法:选取2016年10月-2018年3月期间医院收治的98例结直肠癌患者,随机分为两组,每组49例。对照组单纯采取FOLFOX4化疗方案治疗,在此基础上,观察组加用参苓白术散治疗,对比两组临床疗效、免疫功能、中医证候积分及不良反应发生情况。结果:观察组治疗总有效率较对照组高,差异有统计学意义(P<0.05);治疗后,观察组CD4+及CD4+/CD8+较治疗前升高,CD8+较治疗前降低,且均优于对照组,差异有统计学意义(P<0.05);治疗后,观察组中医证候积分较治疗前降低,且较对照组低,差异有统计学意义(P<0.05);观察组不良反应总发生率较对照组低,差异有统计学意义(P<0.05)。结论:结直肠癌术后化疗患者采用参苓白术散加减方治疗可有效提升临床疗效,增强免疫功能,改善临床症状,且具有较高安全性。
Objective: To investigate the effect of modified Shenling Baizhu recipe on immune function in colorectal cancer patient with postoperative chemotherapy.Methods: 98 patients with colorectal cancer in the hospital from October 2016 to March 2018 were selected,and they were divided into two groups by random number table,with 49 cases in each group.Control group was given FOLFOX 4 chemotherapy regimen,while observation group was treated with Shenling Baizhu powder.The clinical efficacy,immune function,TCM syndrome score and adverse reactions were compared between the two groups.Results The total effective rate of observation group was higher than that of control group(P<0.05); After treatment,the CD4+ and CD4+/CD8+ in observation group increased compared with those before treatment,the CD8+ in observation group decreased compared with that before treatment,and observation group was better than control group(P<0.05); After treatment,the TCM syndrome score of observation group decreased compared with that before treatment,and observation group was lower than control group(P<0.05); The total incidence of adverse reactions in observation group was lower than that in control group(P<0.05).Conclusion: Modified Shenling Baizhu recipe in treatment of colorectal cancer patient with postoperative chemotherapy can increase clinical efficacy,enhance immune function,and improve clinical symptoms,which has higher safety.
Objective: To investigate the effect of modified Shenling Baizhu recipe on immune function in colorectal cancer patient with postoperative chemotherapy.Methods: 98 patients with colorectal cancer in the hospital from October 2016 to March 2018 were selected,and they were divided into two groups by random number table,with 49 cases in each group.Control group was given FOLFOX 4 chemotherapy regimen,while observation group was treated with Shenling Baizhu powder.The clinical efficacy,immune function,TCM syndrome score and adverse reactions were compared between the two groups.Results The total effective rate of observation group was higher than that of control group(P<0.05); After treatment,the CD4+ and CD4+/CD8+ in observation group increased compared with those before treatment,the CD8+ in observation group decreased compared with that before treatment,and observation group was better than control group(P<0.05); After treatment,the TCM syndrome score of observation group decreased compared with that before treatment,and observation group was lower than control group(P<0.05); The total incidence of adverse reactions in observation group was lower than that in control group(P<0.05).Conclusion: Modified Shenling Baizhu recipe in treatment of colorectal cancer patient with postoperative chemotherapy can increase clinical efficacy,enhance immune function,and improve clinical symptoms,which has higher safety.
引文
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[6]齐静.芪附龙葵汤联合化疗治疗转移性结直肠癌患者的有效性与安全性[J].中国药物经济学,2017,12(2):34-36.
[7]金志良,徐炎华.中西医结合联合化疗对晚期结肠癌患者免疫功能及生活质量的影响[J].湖北中医药大学学报,2016,18(2):25-28.
[8]金维,周雪雷,杨鸿.参苓白术散加减治疗结肠癌部分结肠切除术后腹泻的疗效观察[J].四川中医,2016,34(7):148-149.
[9]南宝,李烜.参苓白术散加减组方辅助化疗用于晚期结直肠癌的临床观察[J].中国药房,2016,27(33):4646-4648.
[10]白玉茹,代二庆,高志华,等.参苓白术散辅助治疗结直肠癌患者术后化疗的临床观察[J].中成药,2017,39(2):278-282.
[2]中华人民共和国卫生和计划生育委员会医政医管局.结直肠癌诊疗规范(2015年版)[J].中国实用外科杂志,2015,35(11):1177-1191.
[3]郑筱萸.中药新药临床研究指导原则[M].北京:中国医药科技出版社,2002:371.
[4]穆守印.中西医结合治疗复发/转移性结直肠癌临床研究[J].中医学报,2016,31(5):639-641.
[5]杨兵,杨柱,唐东昕,等.中医药在结直肠癌中的防治作用[J].现代中西医结合杂志,2016,25(21):2389-2392.
[6]齐静.芪附龙葵汤联合化疗治疗转移性结直肠癌患者的有效性与安全性[J].中国药物经济学,2017,12(2):34-36.
[7]金志良,徐炎华.中西医结合联合化疗对晚期结肠癌患者免疫功能及生活质量的影响[J].湖北中医药大学学报,2016,18(2):25-28.
[8]金维,周雪雷,杨鸿.参苓白术散加减治疗结肠癌部分结肠切除术后腹泻的疗效观察[J].四川中医,2016,34(7):148-149.
[9]南宝,李烜.参苓白术散加减组方辅助化疗用于晚期结直肠癌的临床观察[J].中国药房,2016,27(33):4646-4648.
[10]白玉茹,代二庆,高志华,等.参苓白术散辅助治疗结直肠癌患者术后化疗的临床观察[J].中成药,2017,39(2):278-282.