肺水清除相关离子通道的研究进展
摘要
离子通道为存在于细胞膜内的蛋白结构,可以介导水及离子的跨细胞转运。肺泡上皮细胞由多种离子通道构成,这些通道对于维持肺泡内液体清除起到关键作用。因此,离子通道功能受损会导致肺泡内液体增多,从而形成肺水影响肺内气体交换,进一步加重会进展至急性肺损伤及急性呼吸窘迫综合征。相关离子通道有钠离子通道、钾离子通道、非选择性阳离子通道、氯离子通道以及Na~+-K~+-ATP酶,研究这些离子通道可能为肺水肿的治疗提供更好更新的方法。
引文
[1]Matthay MA,Zemans RL.The acute respiratory distress syndrome:pathogenesis and treatment[J].Annu Rev Pathol,2011,620(6):147-163.
[2]Jasti J,Furukawa H,Gonzales EB,et al.Structure of acid-sensing ion channel 1 at 1.9 A resolution and low p H[J].Nature,2007,449(7160):316-323.
[3]Jain L,Chen XJ,Ramosevac S,et al.Expression of highly selective sodium channels in alveolar typeⅡcells is determined by culture conditions[J].Am J Physiol Lung Cell Mol Physiol,2001,280(4):646-658.
[4]Ji HL,Zhao RZ,Chen ZX,et al.delta ENa C:a novel divergent amiloride-inhibitable sodium channel[J].Am J Physiol Lung Cell Mol Physiol,2012,303(12):1013-1026.
[5]Bangel-Ruland N,Sobczak K,Christmann T,et al.Characterization of the epithelial sodium channel delta-subunit in human nasal epithelium[J].Am J Respir Cell Mol Biol,2010,42(4):498-505.
[6]Giraldez T,Rojas P,Jou J,et al.The epithelial sodium channel delta-subunit:new notes for an old song[J].Am J Physiol.Ren physiol,2012,303(3):328-338.
[7]Hummler E,Barker P,Gatzy J,et al.Early death due to defective neonatal lung liquid clearance in alpha-ENa C-deficient mice[J].Nat Genet,1996,12(3):325-328.
[8]Li T,Folkesson HG.RNA interference for alpha-ENa C inhibits rat lung fluid absorption in vivo[J].Am J Physiol Lung Cell Mol Physiol,2006,290(4):649-660.
[9]Randrianarison N,Clerici C,Ferreira C,et al.Low expression of the beta-ENa C subunit impairs lung fluid clearance in the mouse[J].Am J Physiol Lung Cell Mol Physiol,2008,294(3):409-416.
[10]Bardou O,Trinh NT,Brochiero E.Molecular diversity and function of K+channels in airway and alveolar epithelial cells[J].Am J Physiol Lung Cell Mol Physiol,2009,296(2):145-155.
[11]Trinh NT,Prive A,Kheir L,et al.Involvement of KATP and KvLQT1 K+channels in EGF-stimulated alveolar epithelial cell repair processes[J].Am J Physiol Lung Cell Mol Physiol,2007,293(4):870-882.
[12]Han DY,Nie HG,Gu X,et al.K+channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport[J].Respir Res,2010,11:65.
[13]James ZM,Zagotta WN.Structural insights into the mechanisms of CNBD channel function[J].J Gen Physiol,2018,150(2):225-244.
[14]Pifferi S,Boccaccio A,Menini A.Cyclic nucleotide-gated ion channels in sensory transduction[J].FEBS lett,2006,580(12):2853-2859.
[15]Matthay MA,Folkesson HG,Clerici C.Lung epithelial fluid transport and the resolution of pulmonary edema[J].Physiol Rev,2002,82(3):569-600.
[16]Norlin A,Lu LN,Guggino SE,et al.Contribution of amiloride-insensitive pathways to alveolar fluid clearance in adult rats[J].J Appl Physiol,2001,90(4):1489-1496.
[17]Hollenhorst MI,Richter K,Fronius M.Ion transport by pulmonary epithelia[J].J Biomed Biotechnol,2011,2011:174306.
[18]Murray JF.Pulmonary edema:pathophysiology and diagnosis[J].Int J Tuberc Lung Dis,2011,15(2):155-160.
[19]Matthay MA,Robriquet L,Fang X.Alveolar epithelium:role in lung fluid balance and acute lung injury[J].Proc Am Thorac Soc,2005,2(3):206-213.
[20]Gu X,Wang Z,Xu J,et al.Denopamine stimulates alveolar fluid clearance via cystic fibrosis transmembrane conductance regulator in rat lungs[J].Respirology,2006,11(5):566-571.
[21]Fang X,Fukuda N,Barbry P,et al.Novel role for CFTR in fluid absorption from the distal airspaces of the lung[J].J Gen Physiol,2002,119(2):199-207.
[22]Yang YD,Cho H,Koo JY,et al.TMEM16A confers receptor-activated calcium-dependent chloride conductance[J].Nature,2008,455(7217):1210-1215.
[23]Li H,Yan X,Li R,et al.Increased TMEM16A Involved in Alveolar Fluid Clearance After Lipopolysaccharide Stimulation[J].Inflammation,2016,39(2):881-890.
[24]Benedetto R,Ousingsawat J,Wanitchakool P,et al.Epithelial Chloride Transport by CFTR Requires TMEM16A[J].Sci Rep,2017,7(1):12397.
[25]Hoffmann EK,Lambert IH,Pedersen SF.Physiology of cell volume regulation in vertebrates[J].Physiol Rev,2009,89(1):193-277.
[26]Suhail M.Na,K-ATPase:Ubiquitous multifunctional transmembrane protein and its relevance to various pathophysiological conditions[J].J Clin Med Res,2010,2(1):1-17.
[27]Pesce L,Guerrero C,Comellas A,et al.beta-agonists regulate Na,K-ATPase via novel MAPK/ERK and rapamycin-sensitive pathways[J].FEBS Lett,2000,486(3):310-314.
[28]Factor P,Dumasius V,Saldias F,et al.Adenovirus-mediated transfer of an Na+/K+-ATPase beta1 subunit gene improves alveolar fluid clearance and survival in hyperoxic rats[J].Hum Gene Ther,2000,11(16):2231-2242.
[2]Jasti J,Furukawa H,Gonzales EB,et al.Structure of acid-sensing ion channel 1 at 1.9 A resolution and low p H[J].Nature,2007,449(7160):316-323.
[3]Jain L,Chen XJ,Ramosevac S,et al.Expression of highly selective sodium channels in alveolar typeⅡcells is determined by culture conditions[J].Am J Physiol Lung Cell Mol Physiol,2001,280(4):646-658.
[4]Ji HL,Zhao RZ,Chen ZX,et al.delta ENa C:a novel divergent amiloride-inhibitable sodium channel[J].Am J Physiol Lung Cell Mol Physiol,2012,303(12):1013-1026.
[5]Bangel-Ruland N,Sobczak K,Christmann T,et al.Characterization of the epithelial sodium channel delta-subunit in human nasal epithelium[J].Am J Respir Cell Mol Biol,2010,42(4):498-505.
[6]Giraldez T,Rojas P,Jou J,et al.The epithelial sodium channel delta-subunit:new notes for an old song[J].Am J Physiol.Ren physiol,2012,303(3):328-338.
[7]Hummler E,Barker P,Gatzy J,et al.Early death due to defective neonatal lung liquid clearance in alpha-ENa C-deficient mice[J].Nat Genet,1996,12(3):325-328.
[8]Li T,Folkesson HG.RNA interference for alpha-ENa C inhibits rat lung fluid absorption in vivo[J].Am J Physiol Lung Cell Mol Physiol,2006,290(4):649-660.
[9]Randrianarison N,Clerici C,Ferreira C,et al.Low expression of the beta-ENa C subunit impairs lung fluid clearance in the mouse[J].Am J Physiol Lung Cell Mol Physiol,2008,294(3):409-416.
[10]Bardou O,Trinh NT,Brochiero E.Molecular diversity and function of K+channels in airway and alveolar epithelial cells[J].Am J Physiol Lung Cell Mol Physiol,2009,296(2):145-155.
[11]Trinh NT,Prive A,Kheir L,et al.Involvement of KATP and KvLQT1 K+channels in EGF-stimulated alveolar epithelial cell repair processes[J].Am J Physiol Lung Cell Mol Physiol,2007,293(4):870-882.
[12]Han DY,Nie HG,Gu X,et al.K+channel openers restore verapamil-inhibited lung fluid resolution and transepithelial ion transport[J].Respir Res,2010,11:65.
[13]James ZM,Zagotta WN.Structural insights into the mechanisms of CNBD channel function[J].J Gen Physiol,2018,150(2):225-244.
[14]Pifferi S,Boccaccio A,Menini A.Cyclic nucleotide-gated ion channels in sensory transduction[J].FEBS lett,2006,580(12):2853-2859.
[15]Matthay MA,Folkesson HG,Clerici C.Lung epithelial fluid transport and the resolution of pulmonary edema[J].Physiol Rev,2002,82(3):569-600.
[16]Norlin A,Lu LN,Guggino SE,et al.Contribution of amiloride-insensitive pathways to alveolar fluid clearance in adult rats[J].J Appl Physiol,2001,90(4):1489-1496.
[17]Hollenhorst MI,Richter K,Fronius M.Ion transport by pulmonary epithelia[J].J Biomed Biotechnol,2011,2011:174306.
[18]Murray JF.Pulmonary edema:pathophysiology and diagnosis[J].Int J Tuberc Lung Dis,2011,15(2):155-160.
[19]Matthay MA,Robriquet L,Fang X.Alveolar epithelium:role in lung fluid balance and acute lung injury[J].Proc Am Thorac Soc,2005,2(3):206-213.
[20]Gu X,Wang Z,Xu J,et al.Denopamine stimulates alveolar fluid clearance via cystic fibrosis transmembrane conductance regulator in rat lungs[J].Respirology,2006,11(5):566-571.
[21]Fang X,Fukuda N,Barbry P,et al.Novel role for CFTR in fluid absorption from the distal airspaces of the lung[J].J Gen Physiol,2002,119(2):199-207.
[22]Yang YD,Cho H,Koo JY,et al.TMEM16A confers receptor-activated calcium-dependent chloride conductance[J].Nature,2008,455(7217):1210-1215.
[23]Li H,Yan X,Li R,et al.Increased TMEM16A Involved in Alveolar Fluid Clearance After Lipopolysaccharide Stimulation[J].Inflammation,2016,39(2):881-890.
[24]Benedetto R,Ousingsawat J,Wanitchakool P,et al.Epithelial Chloride Transport by CFTR Requires TMEM16A[J].Sci Rep,2017,7(1):12397.
[25]Hoffmann EK,Lambert IH,Pedersen SF.Physiology of cell volume regulation in vertebrates[J].Physiol Rev,2009,89(1):193-277.
[26]Suhail M.Na,K-ATPase:Ubiquitous multifunctional transmembrane protein and its relevance to various pathophysiological conditions[J].J Clin Med Res,2010,2(1):1-17.
[27]Pesce L,Guerrero C,Comellas A,et al.beta-agonists regulate Na,K-ATPase via novel MAPK/ERK and rapamycin-sensitive pathways[J].FEBS Lett,2000,486(3):310-314.
[28]Factor P,Dumasius V,Saldias F,et al.Adenovirus-mediated transfer of an Na+/K+-ATPase beta1 subunit gene improves alveolar fluid clearance and survival in hyperoxic rats[J].Hum Gene Ther,2000,11(16):2231-2242.