肺泡内液体清除机制研究进展
摘要
肺水肿是临床常见疾病,肺泡液的吸收和消散对于减慢肺水肿的形成速度、改善肺水肿的预后至关重要。本文从上皮钠通道、水通道蛋白、β受体激动剂、上皮氯通道、α受体激动剂5个方面介绍了肺泡液体清除机制的研究进展,并简要介绍酸敏感离子通道及γ-氨基丁酸受体在肺泡液体清除中的作用机制。
引文
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[9]谷秀,张天彪.氯离子通道在离体人肺泡上皮液体清除过程中的作用[J].山东医药,2010,50(16):60-62.
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[13]Xiang YY,Wang S,Liu M,et al.A GABAergic system in airway epithelium is essential for mucus overproduction in asthma[J].Nat Med,2007,13(7):862-867.
[14]Zhao D,Ning N,Lei Z,et al.Identification of a novel protein complex containing ASIC1a and GABAA receptors and their interregulation[J].PLo S One,2014,9(6):99735.
[2]Wang Q,Lian QQ,Li R,et al.Lipoxin A(4)activates alveolar epithelial sodium channel,Na,K-ATPase,and increases alveolar fluid clearance[J].Am J Respir Cell Mol Biol,2013,48(5):610-618.
[3]于同,崔湧.布比卡因影响小鼠肺泡上皮液体清除的作用机制研究[J].山东医药,2012,52(39):18-20.
[4]Li J,XU M,FAN Q,et al.Tanshinone IIA ameliorates seawater exposureinduced lung injury by inhibiting aquaporins(AQP)1 and AQPS expression in lung[J].Respir Physiol Neurobiol,2011,176(1/2):39-49.
[5]Gao J,Zhou L,Ge Y,et al.Effects of different resuscitation fluids on pulmonary expression of aquaporinl and aquaporin5 in a rat model of uncontrolled hemorrhagic shock and infection[J].PLo S One,2013,8(5):64390.
[6]Jin LD,Wang LR,Wu LQ,et al.Effects of COX-2 inhibitor on entilator-induced lung injury in rats[J].Int Immunopharmacol,2013,16(2):288-295.
[7]Zhao S,Li XN.Expression of aquaporin-1 and aquaporin-3 in lung tissue of rat model with ischemia-reperfusion injury[J].Chinese Medical Journal(English),2010,123(24):3711-3713.
[8]Li Z,Gao C,Wang Y,et al.Reducing pulmonary injury by hyperbaric oxygen reconditioning during simulated high altitude exposure in rats[J].J Trauma,2011,71(3):673-679.
[9]谷秀,张天彪.氯离子通道在离体人肺泡上皮液体清除过程中的作用[J].山东医药,2010,50(16):60-62.
[10]谷秀,李胜岐.佐久间勉.苯肾上腺素对离体大鼠肺泡液体清除率的影响[J].中国现代医学杂志.2005.6.15(12):1786-1789.
[11]Tan ZY,Lu YJ,Whiteis CA,et al.Chemoreceptor hypersensitivity,sympathetic excitation,and over expression of ASIC and TASK channels before the onset of hypertension in SHR[J].Circ Res,2010,106(3):536-554.
[12]Yu Y,Chen Z,Li WG,et al.A nonproton ligand sensor in the acid-sensing ion channel[J].Neuron,2010,68(1):61-72.
[13]Xiang YY,Wang S,Liu M,et al.A GABAergic system in airway epithelium is essential for mucus overproduction in asthma[J].Nat Med,2007,13(7):862-867.
[14]Zhao D,Ning N,Lei Z,et al.Identification of a novel protein complex containing ASIC1a and GABAA receptors and their interregulation[J].PLo S One,2014,9(6):99735.