模拟低压低氧环境对小鼠肺组织形态结构的影响
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摘要
以肺组织显微结构、超微结构及部分血氧值为指标,以雄性昆明系小鼠为实验对象,观察了低压氧舱模拟不同海拔环境对小鼠肺组织形态结构的影响。结果表明,试验组小鼠肺泡隔厚度,肺气—血屏障算术平均厚度,动、静脉氧分压差和动、静脉血氧饱和度差均高于对照组,且差异显著(P<0.05)。这是低氧环境对小鼠肺组织造成的改变,这种改变可保证其适应低氧环境。
In the present study, the effects of different altitudes environment simulated in hypobaric cabin on morphological structure of lung tissues in male Kunming mice was assessed using microstructure and ultrastructure of lung tissues and selected blood oxygen values. The results showed that the mice in the simulated hypobaric hypoxia environment had significantly higher thickness of alveolar septum, arithmetic mean thickness of the lung air-blood barrier, arteriovenous oxygen difference, and arterial and venous blood oxygen saturation difference(P<0.05). The morphological structure changes of the lung tissues in mice was caused by the hypobaric hypoxia environment, providing the adaptability to the hypobaric hypoxia environment.
In the present study, the effects of different altitudes environment simulated in hypobaric cabin on morphological structure of lung tissues in male Kunming mice was assessed using microstructure and ultrastructure of lung tissues and selected blood oxygen values. The results showed that the mice in the simulated hypobaric hypoxia environment had significantly higher thickness of alveolar septum, arithmetic mean thickness of the lung air-blood barrier, arteriovenous oxygen difference, and arterial and venous blood oxygen saturation difference(P<0.05). The morphological structure changes of the lung tissues in mice was caused by the hypobaric hypoxia environment, providing the adaptability to the hypobaric hypoxia environment.
引文
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[13]张晶晶,张勤文,俞红贤,等.大通牦牛肺血管低氧适应的组织结构特点[J].江苏农业科学,2016,44(6):346-347.
[2]高钰琪.高原病理生理学[M].北京:人民卫生出版社,2006.
[3]高钰琪,黄庆愿,刘福玉.促进高原习服措施的研究进展[J].解放军预防医学杂志,2002(4):306-309.
[4]白谊涵,马全福,张永青,等.高原低氧环境对心血管系统影响的研究[J].中国急救复苏与灾害医学杂志,2012,7(3):217-220.
[5]袁青研,谢庄.动物对高原低氧的适应性研究进展[J].生理科学进展,2005,36(2):179-182.
[6]刘健,王培勇,罗德成,等.5-羟色胺对肺动脉平滑肌细胞在缺氧条件下增殖的作用[J].生理学报,1997,49(3):292-298.
[7]郑富盛.细胞形态立体计量学[M].北京:北京医科大学、中国协和医科大学联合出版社,1990.
[8]俞红贤.藏羊肺组织形态测量指标及其与高原低氧的关系[J].中国兽医科技,1999,29(7):15-16.
[9]张勤文.不同海拔地区牦牛的肺组织形态学比较[J].中国兽医科技,2004,34(2):73-74.
[10]姚芳,张勤文.大通牦牛肺微血管的增龄性变化特点[J].黑龙江畜牧兽医,2015(9上):98-100.
[11]张勤文,俞红贤,李莉,等.大通牦牛肺气—血屏障超微结构的发育学研究[J].黑龙江畜牧兽医,2015(9上):230-231,235.
[12]张晶晶,张勤文,俞红贤,等.大通牦牛肺血管显微结构的增龄性变化特点[J].黑龙江畜牧兽医,2016(5上):27-29.
[13]张晶晶,张勤文,俞红贤,等.大通牦牛肺血管低氧适应的组织结构特点[J].江苏农业科学,2016,44(6):346-347.