热毒宁联合沙丁胺醇雾化吸入治疗小儿哮喘性支气管炎45例分析
摘要
<正>小儿哮喘性支气管炎是一种婴幼儿的支气管感染,发病机制复杂,可能与炎症细胞因子和炎症介质有关,如中性粒细胞、淋巴细胞、气道上皮细胞、白细胞介素8(interleukin-8,IL-8)、IL-10、转化生长因子β(transforming growth factor-beta,TGF-β)等。支气管气道发生炎症反应时,气道呈高反应性状态,再加上外界多种刺激因素,气道阻塞、气流受限,患儿易伴有反复发作的喘息。相关研究显示,热毒宁注射液具有降低炎症反应、抑制黏液分泌、舒张支气管的作用,沙丁胺醇以吸入给药方式为主,吸入后迅速起效,作用维持时间较短,其吸入后5～10 min起效,
引文
1李菲,马建梅,张苏梅,等.小儿肺热咳喘口服液联合热毒宁注射液治疗儿童毛细支气管炎的疗效观察[J].现代药物与临床,2018,33(1):88-92.
2 Ong HX, Traini D, Ballerin G, et al.Combined inhaled salbutamol and mannitol therapy for mucus hypersecretion in pulmonary diseases[J].AAPS J, 2014, 16(2):269-280.
3 Hassan A, Salah Eldin R, Abdelrahman MM, et al.In-vitro/in-vivo comparison of inhaled salbutamol dose delivered by jet nebulizer, vibrating mesh nebulizer and metered dose inhaler with spacer during non-invasive ventilation[J].Exp Lung Res, 2017, 43(1):19-28.
4 中华医学会儿科学分会呼吸学组,中华医学会《中华儿科杂志》编辑委员会.儿童支气管哮喘防治常规(试行)[J].中华儿科杂志,2004,42(1):100-106.
5 Sastre B, del Pozo V.Role of in asthma and nonasthmatic eosinophilic bronchitis[J].Mediators Inflamm,2012:645383.
6 张东海,马翠玲,杨伟娜,等.热毒宁注射液联合阿奇霉素和细辛脑注射液治疗儿童支原体肺炎的临床研究[J].现代药物与临床,2016,31(5):604-607.
7 Foncerrada G, Lima F, Clayton RP, et al.Safety of nebulized epinephrine in smoke inhalationinjury[J].J Burn Care Res, 2017, 38(6):396-402.
8 Ogawa H, Fujimura M, Ohkura N, et al.Effects of nebulized amphotericin B and budesonide inhalation for chronic cough-related laryngeal sensations[J].Auris Nasus Larynx, 2015, 42(3):221-225.
9 Shoeib WK, Alsalahy MM, Almahdy MA, et al.Study of effect of inhaled versus oral corticosteroids on sputum granzyme B in patients with moderate persistent bronchial asthma[J].Egypt J Chest Dis Tuberc, 2015,64(1):7-11.
10 Kyung SY, Yoon JY, Kim YJ, et al.Asian dust particles induce TGF-β1via reactive oxygen species in bronchial epithelial cells[J].Tuberc Respir Dis(Seoul),2012, 73(2):84-92.
11 李郁,周永红,傅存冀.热毒宁注射液治疗儿童支气管肺炎的临床观察[J].中国医院用药评价与分析,2013,13(8):725-728.
2 Ong HX, Traini D, Ballerin G, et al.Combined inhaled salbutamol and mannitol therapy for mucus hypersecretion in pulmonary diseases[J].AAPS J, 2014, 16(2):269-280.
3 Hassan A, Salah Eldin R, Abdelrahman MM, et al.In-vitro/in-vivo comparison of inhaled salbutamol dose delivered by jet nebulizer, vibrating mesh nebulizer and metered dose inhaler with spacer during non-invasive ventilation[J].Exp Lung Res, 2017, 43(1):19-28.
4 中华医学会儿科学分会呼吸学组,中华医学会《中华儿科杂志》编辑委员会.儿童支气管哮喘防治常规(试行)[J].中华儿科杂志,2004,42(1):100-106.
5 Sastre B, del Pozo V.Role of in asthma and nonasthmatic eosinophilic bronchitis[J].Mediators Inflamm,2012:645383.
6 张东海,马翠玲,杨伟娜,等.热毒宁注射液联合阿奇霉素和细辛脑注射液治疗儿童支原体肺炎的临床研究[J].现代药物与临床,2016,31(5):604-607.
7 Foncerrada G, Lima F, Clayton RP, et al.Safety of nebulized epinephrine in smoke inhalationinjury[J].J Burn Care Res, 2017, 38(6):396-402.
8 Ogawa H, Fujimura M, Ohkura N, et al.Effects of nebulized amphotericin B and budesonide inhalation for chronic cough-related laryngeal sensations[J].Auris Nasus Larynx, 2015, 42(3):221-225.
9 Shoeib WK, Alsalahy MM, Almahdy MA, et al.Study of effect of inhaled versus oral corticosteroids on sputum granzyme B in patients with moderate persistent bronchial asthma[J].Egypt J Chest Dis Tuberc, 2015,64(1):7-11.
10 Kyung SY, Yoon JY, Kim YJ, et al.Asian dust particles induce TGF-β1via reactive oxygen species in bronchial epithelial cells[J].Tuberc Respir Dis(Seoul),2012, 73(2):84-92.
11 李郁,周永红,傅存冀.热毒宁注射液治疗儿童支气管肺炎的临床观察[J].中国医院用药评价与分析,2013,13(8):725-728.