贝那普利联合骨化三醇对糖尿病肾病患者肾功能指标和微炎症因子水平的影响观察
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摘要
目的观察贝那普利联合骨化三醇治疗早期糖尿病肾病,对患者肾功能指标和微炎症因子水平的影响。方法将该院收治的96例早期糖尿病肾病患者随机分为对照组和观察组,各48例。对照组采用单纯贝那普利治疗,观察组采用贝那普利联合骨化三醇治疗。对两组患者的血糖指标、肾功能指标、炎症因子水平、治疗效果和不良反应发生情况进行分析比较。结果两组血糖检测结果和不良反应发生率比较差异均无统计学意义(P> 0. 05)。观察组肾功能指标和炎症因子水平检测结果均低于对照组,治疗总有效率高于对照组,差异均有统计学意义(P <0. 05)。结论对早期糖尿病肾病患者,采取贝那普利联合骨化三醇治疗,有效改善了患者的肾功能指标,降低了炎症反应,提高了患者的治疗效果。
Objective To observe the effects of benapril combined with calcitriol on renal function indices and microinflammatory factors in early diabetic nephropathy patients. Methods Ninty-six early diabetie nephropathy patients were divided into control group and observation group,with 48 cases in each group. The control group was treated with benapril and the observation group was treated with benapril combined with calcitriol. The therapeutic effect,blood glucose,renal function indices,inflammatory factor level and adverse reaction were compared between the two groups. Results There were no significant differences in blood glucose level and adverse reaction rate between the two groups( P > 0. 05). The renal function indices and inflammatory factor level of the observation group were significantly lower than those of the control group,and the total therapeutic efficiency of the observation group was significantly higher than that of the control group( P < 0. 05). Conclusion Benapril combined with calcitriol can improve the therapeutic effect of patients with early diabetic nephropathy.
Objective To observe the effects of benapril combined with calcitriol on renal function indices and microinflammatory factors in early diabetic nephropathy patients. Methods Ninty-six early diabetie nephropathy patients were divided into control group and observation group,with 48 cases in each group. The control group was treated with benapril and the observation group was treated with benapril combined with calcitriol. The therapeutic effect,blood glucose,renal function indices,inflammatory factor level and adverse reaction were compared between the two groups. Results There were no significant differences in blood glucose level and adverse reaction rate between the two groups( P > 0. 05). The renal function indices and inflammatory factor level of the observation group were significantly lower than those of the control group,and the total therapeutic efficiency of the observation group was significantly higher than that of the control group( P < 0. 05). Conclusion Benapril combined with calcitriol can improve the therapeutic effect of patients with early diabetic nephropathy.
引文
1余晓波,余永壮.糖尿病肾病的发病机制及治疗进展[J].中国临床新医学,2017,10(10):1022-1023.
2李红微,刘胜阳,刘云霞,等.替米沙坦治疗早期糖尿病肾病的效果观察[J].中国当代医药,2016,23(4):73-75.
3牟严艳,林梅珍,李丹,等.替米沙坦与胰激肽原酶联合治疗早期糖尿病肾病的有效性分析[J].中国医药科学,2018,8(8):27-29.
4熊燕.余江毅教授治疗糖尿病肾病经验[J].环球中医药,2015,8(4):474-475.
5张薇,焦凯.早期糖尿病肾病的预防及治疗进展[J].实用医院临床杂志,2014,11(3):186-188.
6尹军四.贝那普利与前列地尔联合治疗糖尿病肾病临床效果观察[J].临床合理用药杂志,2015,8(26):49-50.
7陈菁华.前列地尔联合贝那普利治疗糖尿病肾病蛋白尿的临床疗效分析[J].中国医药科学,2015,5(16):57-59.
8陈钦宏.前列地尔联合贝那普利治疗糖尿病肾病蛋白尿患者的临床疗效分析[J].中国临床新医学,2016,9(7):608-611.
9余翠,熊钱颖,王李卓,等.糖尿病肾病的发病机制及治疗进展[J].医学综述,2015,21(21):3944-3947.
10伍晓聪,武革.糖化血红蛋白与糖尿病肾病[J].中国临床新医学,2018,11(1):97-100.
11管红斌,黄华,桓文穆,等.骨化三醇联合替米沙坦治疗糖尿病肾病的疗效[J].广东医学,2012,33(16):2488-2490.
12翟翠云,王洪光.骨化三醇的临床应用与不良反应[J].中国医药技术经济与管理,2008,2(9):69-72.
13王文菊,孔云龙.二甲双胍联合骨化三醇对2型糖尿病患者肾功能及视网膜的保护作用[J].中国药房,2016,27(30):4427-4230.
14刁兵,张道友.氯沙坦联合骨化三醇对糖尿病肾病患者血清TGF-β1的影响[J].锦州医科大学学报,2017,38(1):33-36,115.
2李红微,刘胜阳,刘云霞,等.替米沙坦治疗早期糖尿病肾病的效果观察[J].中国当代医药,2016,23(4):73-75.
3牟严艳,林梅珍,李丹,等.替米沙坦与胰激肽原酶联合治疗早期糖尿病肾病的有效性分析[J].中国医药科学,2018,8(8):27-29.
4熊燕.余江毅教授治疗糖尿病肾病经验[J].环球中医药,2015,8(4):474-475.
5张薇,焦凯.早期糖尿病肾病的预防及治疗进展[J].实用医院临床杂志,2014,11(3):186-188.
6尹军四.贝那普利与前列地尔联合治疗糖尿病肾病临床效果观察[J].临床合理用药杂志,2015,8(26):49-50.
7陈菁华.前列地尔联合贝那普利治疗糖尿病肾病蛋白尿的临床疗效分析[J].中国医药科学,2015,5(16):57-59.
8陈钦宏.前列地尔联合贝那普利治疗糖尿病肾病蛋白尿患者的临床疗效分析[J].中国临床新医学,2016,9(7):608-611.
9余翠,熊钱颖,王李卓,等.糖尿病肾病的发病机制及治疗进展[J].医学综述,2015,21(21):3944-3947.
10伍晓聪,武革.糖化血红蛋白与糖尿病肾病[J].中国临床新医学,2018,11(1):97-100.
11管红斌,黄华,桓文穆,等.骨化三醇联合替米沙坦治疗糖尿病肾病的疗效[J].广东医学,2012,33(16):2488-2490.
12翟翠云,王洪光.骨化三醇的临床应用与不良反应[J].中国医药技术经济与管理,2008,2(9):69-72.
13王文菊,孔云龙.二甲双胍联合骨化三醇对2型糖尿病患者肾功能及视网膜的保护作用[J].中国药房,2016,27(30):4427-4230.
14刁兵,张道友.氯沙坦联合骨化三醇对糖尿病肾病患者血清TGF-β1的影响[J].锦州医科大学学报,2017,38(1):33-36,115.