阿莫西林克拉维酸钾治疗小儿尿路感染的临床研究
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摘要
目的探讨阿莫西林克拉维酸钾治疗小儿尿路感染的临床效果。方法选取2017年1月至2018年12月我院收治的53例尿路感染患儿,根据治疗方法不同分为两组。对照组(26例)采用复方磺胺甲恶唑片治疗,实验组(27例)采用阿莫西林克拉维酸钾分散片治疗。观察两组的治疗效果、细菌清除率及不良反应情况。结果实验组的总有效率为96.3%,明显高于对照组的76.9%(P <0.05)。治疗后,两组各菌株数量均少于治疗前(P <0.05);实验组的细菌清除率为92.6%,高于对照组的69.2%(P <0.05)。两组治疗期间均未见严重不良反应,仅对照组1例出现轻微胃肠道反应,两组的不良反应发生率比较无统计学差异(P>0.05)。结论采用阿莫西林克拉维酸钾治疗小儿尿路感染疗效确切,可更有效清除细菌,安全性较高,值得临床应用。
Objective To explore the clinical effect of amoxicillin and clavulanate potassium in the treatment of children with urinary tract infection. Methods 53 cases of children with urinary tract infection admitted to our hospital from January 2017 to December 2018 were selected and randomly divided into two groups according to different treatment methods. The control group(26 cases) was treated with compound sulfamethoxazole tablets, and the experimental group(27 cases) was treated with amoxicillin and clavulanate potassium dispersible tablets. The treatment effects, bacterial clearance rate and adverse reactions of the two groups were observed. Results The total effective rate of the experimental group was 96.3%, significantly higher than 76.9% of the control group(P <0.05). After treatment, the numbers of strains in the two groups were lower than those before treatment(P <0.05); The bacterial clearance rate of the experimental group was 92.6%, higher than 69.2% of the control group(P <0.05). No serious adverse reactions were found in both groups during treatment, but only 1 case with mild gastrointestinal reactions in the control group. No statistical difference was found in the incidence of adverse reactions between the two groups(P >0.05). Conclusions Amoxicillin and clavulanate potassium in the treatment of children with urinary tract infection has definite curative effect, and can effectively remove the bacteria with higher safety, which is worthy of clinical application.
Objective To explore the clinical effect of amoxicillin and clavulanate potassium in the treatment of children with urinary tract infection. Methods 53 cases of children with urinary tract infection admitted to our hospital from January 2017 to December 2018 were selected and randomly divided into two groups according to different treatment methods. The control group(26 cases) was treated with compound sulfamethoxazole tablets, and the experimental group(27 cases) was treated with amoxicillin and clavulanate potassium dispersible tablets. The treatment effects, bacterial clearance rate and adverse reactions of the two groups were observed. Results The total effective rate of the experimental group was 96.3%, significantly higher than 76.9% of the control group(P <0.05). After treatment, the numbers of strains in the two groups were lower than those before treatment(P <0.05); The bacterial clearance rate of the experimental group was 92.6%, higher than 69.2% of the control group(P <0.05). No serious adverse reactions were found in both groups during treatment, but only 1 case with mild gastrointestinal reactions in the control group. No statistical difference was found in the incidence of adverse reactions between the two groups(P >0.05). Conclusions Amoxicillin and clavulanate potassium in the treatment of children with urinary tract infection has definite curative effect, and can effectively remove the bacteria with higher safety, which is worthy of clinical application.
引文
[1]杜春蕴.阿莫西林克拉维酸钾治疗小儿泌尿系感染临床观察[J].中国实用医药, 2014, 9(13):138-139.
[2]杨永莲.注射用阿莫西林克拉维酸钾治疗小儿泌尿系感染的临床观察[J].中国医药指南, 2015, 13(11):119-120.
[3]樊成.小儿泌尿系感染78例临床分析[J].医学信息, 2013, 26(2):164.
[4]易著文,张星星.儿童泌尿系感染的诊治进展[J].中国实用儿科杂志, 2004, 19(2):76-78.
[5]颜容.阿莫西林/克拉维酸钾颗粒口服治疗小儿泌尿系感染45例疗效观察[J].健康必读, 2013, 12(8):21-22.
[6]吴忠,韩宇,李海珠,等.小儿尿路感染的常见病因及临床特点研究[J].中华医院感染学杂志, 2018, 28(13):2040-2043.
[7]陈朴,张立营,严羽,等.小儿尿路感染的病原微生物分布及常见抗生素的药敏分析[J].河北医药, 2016, 38(16):2531-2532, 2536.
[8]樊均明,李孜,唐嵘,等.阿莫西林/克拉维酸钾治疗尿路感染的临床研究[J].中国中西医结合肾病杂志, 2003, 4(1):24-25.
[9]廖伟,赵聪敏,温恩懿,等.阿莫西林/克拉维酸钾干混悬剂口服治疗小儿泌尿系感染临床观察[J].中国实用儿科杂志, 2010, 25(6):475-477.
[2]杨永莲.注射用阿莫西林克拉维酸钾治疗小儿泌尿系感染的临床观察[J].中国医药指南, 2015, 13(11):119-120.
[3]樊成.小儿泌尿系感染78例临床分析[J].医学信息, 2013, 26(2):164.
[4]易著文,张星星.儿童泌尿系感染的诊治进展[J].中国实用儿科杂志, 2004, 19(2):76-78.
[5]颜容.阿莫西林/克拉维酸钾颗粒口服治疗小儿泌尿系感染45例疗效观察[J].健康必读, 2013, 12(8):21-22.
[6]吴忠,韩宇,李海珠,等.小儿尿路感染的常见病因及临床特点研究[J].中华医院感染学杂志, 2018, 28(13):2040-2043.
[7]陈朴,张立营,严羽,等.小儿尿路感染的病原微生物分布及常见抗生素的药敏分析[J].河北医药, 2016, 38(16):2531-2532, 2536.
[8]樊均明,李孜,唐嵘,等.阿莫西林/克拉维酸钾治疗尿路感染的临床研究[J].中国中西医结合肾病杂志, 2003, 4(1):24-25.
[9]廖伟,赵聪敏,温恩懿,等.阿莫西林/克拉维酸钾干混悬剂口服治疗小儿泌尿系感染临床观察[J].中国实用儿科杂志, 2010, 25(6):475-477.