芪蛭肾安丸对5/6肾切除肾衰大鼠的肾保护作用
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摘要
目的观察芪蛭肾安丸对5/6肾切除肾衰大鼠的肾保护作用。方法 SD雄性大鼠随机分为正常对照组、模型对照组、芪蛭肾安丸(1.0 g/kg)组、芪蛭肾安丸(2.0 g/kg)组、芪蛭肾安丸(4.0 g/kg)组和尿毒清颗粒组,每组8只。5/6肾切除建立慢性肾衰竭(CRF)大鼠模型,给药组大鼠连续用药6周后,检测血脂,肾功能及尿量、蛋白尿的变化。结果与模型对照组比较,芪蛭肾安丸(1.0 g/kg、2.0 g/kg、4.0 g/kg组大鼠尿量明显增加(P<0.05),蛋白尿、BUN、Cr、TC、TG均明显减低(P<0.01)。结论芪蛭肾安丸对模型大鼠肾脏具有保护作用,它可能是通过调节脂代谢、降低蛋白尿而实现的。
Objective It is to observe the renal protective effect of Qizhi shenan pills in 5/6 nephrectomy rats with renal failure.Methods SD rats were randomly divided into normal control group,model control group,Qizhishenan pill(1.0 g/kg)group,Qizhishenan pill(2.0 g/kg)group,Qizhishenan pills(4.0 g/kg)group and Niaoduqing particle group,8 rats in each group.5/6 nephrectomy was used to establish chronic renal failure(CRF) rat model.After continuous medication of six weeks in drug administration group,the changes of serum lipids,renal function and urine volume,urinary protein were determined.Results Compared with model control group,urine volume increased significantly(P<0.05),urinary protein,BUN,Cr,TC and TG were significantly lower(P<0.01) in Qizhishenan pill groups including(1.0 g/kg,2.0 g/kg,4.0 g/kg).Conclusion Qizhishenan pills have a kidney protective effect for the rat models of CRF which may be achieved by regulating fat metabolism and reducing proteinuria.
Objective It is to observe the renal protective effect of Qizhi shenan pills in 5/6 nephrectomy rats with renal failure.Methods SD rats were randomly divided into normal control group,model control group,Qizhishenan pill(1.0 g/kg)group,Qizhishenan pill(2.0 g/kg)group,Qizhishenan pills(4.0 g/kg)group and Niaoduqing particle group,8 rats in each group.5/6 nephrectomy was used to establish chronic renal failure(CRF) rat model.After continuous medication of six weeks in drug administration group,the changes of serum lipids,renal function and urine volume,urinary protein were determined.Results Compared with model control group,urine volume increased significantly(P<0.05),urinary protein,BUN,Cr,TC and TG were significantly lower(P<0.01) in Qizhishenan pill groups including(1.0 g/kg,2.0 g/kg,4.0 g/kg).Conclusion Qizhishenan pills have a kidney protective effect for the rat models of CRF which may be achieved by regulating fat metabolism and reducing proteinuria.
引文
[1]Hu C,Kang BY,Megyesi J,et al.Deletion of LOX-1 attenuates re-nal injury following angiotensinⅡinfusion[J].Kidney Int,2009,76(5):521-527
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[3]陈孝文,刘华锋,刘伟敬.基于蛋白尿的慢性肾脏疾病防治研究[J].中国中西医结合肾病杂志,2011,12(11):941-945
[4]刘优友.蛋白尿致肾小管纤维化的机制及治疗[J].中华肾脏病杂志,2006,22(4):259-260
[2]Kelly KJ,Wu P,Patterson CE,et al.LOX-1 and inflammation:anew mechanism for renal injury in obesity and diabetes[J].Am Jphysiol Renal physiol,2008,294(5):F1136-1145
[3]陈孝文,刘华锋,刘伟敬.基于蛋白尿的慢性肾脏疾病防治研究[J].中国中西医结合肾病杂志,2011,12(11):941-945
[4]刘优友.蛋白尿致肾小管纤维化的机制及治疗[J].中华肾脏病杂志,2006,22(4):259-260