垂体后叶素治疗咯血致低钠血症的药学监护
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摘要
目的分析垂体后叶素导致低钠血症的原因以及临床药师在治疗期间的作用。方法临床药师参与1例垂体后叶素治疗咯血的药物治疗,分析发生低钠血症的原因,协助医师调整药物治疗方案,监测血电解质浓度,避免不良后果发生。结果医师采纳临床药师建议,患者咯血症状好转,血钠水平恢复稳定。结论临床药师参与治疗方案的制订和调整,为患者的用药安全提供保障。
Objective To analyze the causes of persistent hyponatremia induced by pituitrin and the role of clinical pharmacists during treatment. Methods The clinical pharmacist participated in the analysis of hyponatremia in the course of drug treatment of hemoptysis with pituitrin in 1 case,assisted the physician to adjust the drug treatment program,monitored the blood electrolyte concentration,and avoided adverse consequences. Results The physician adopted the advice of the clinical pharmacists,and the patient ' s hemoptysis improved,and blood sodium level returned to stability. Conclusion The participation of clinical pharmacists in the formulation and adjustment of treatment programs can guarantee the safety of patients' medications.
Objective To analyze the causes of persistent hyponatremia induced by pituitrin and the role of clinical pharmacists during treatment. Methods The clinical pharmacist participated in the analysis of hyponatremia in the course of drug treatment of hemoptysis with pituitrin in 1 case,assisted the physician to adjust the drug treatment program,monitored the blood electrolyte concentration,and avoided adverse consequences. Results The physician adopted the advice of the clinical pharmacists,and the patient ' s hemoptysis improved,and blood sodium level returned to stability. Conclusion The participation of clinical pharmacists in the formulation and adjustment of treatment programs can guarantee the safety of patients' medications.
引文
[1]李季泓.垂体后叶素治疗咯血引起低钠血症的回顾性分析[J].临床药物治疗杂志,2015,13(4):50-53.
[2]金淑萍,高永丽,李成建.多索茶碱不良反应文献概述[J].中国药物滥用防治杂志,2015,21(6):362-363.
[3]赵莹,李国军,李成建.美洛西林钠/舒巴坦钠不良反应文献概述[J].中国药物滥用防治杂志,2015,21(1):50,62.
[4]Vasostric(vasopressin injection,USP)for intravenous infusion,FDA,2014.
[5]陈宇星,冯淑玲,孙红.垂体后叶素的不良反应与安全应用[J].福建医药杂志,2008,30(2):121-123.
[6]XU T T,LI J,FENG J C,et al.A rare case of pituitrininduced delayed encephalopathy[J].Pak J Med Sci,2014,30(5):1141-1142.
[7]江苔,杨仁辉,冯元凤,等.垂体后叶素治疗大咯血致电解质紊乱20例临床分析[J].中国实用内科杂志,2015,35(S1):44-45.
[8]陈江声,杨燕娇.小剂量与大剂量垂体后叶素对大咯血的疗效及副作用比较[J].实用医学杂志,2007,23(1):99-100.
[9]叶婷婷,王长江.低钠血症的诊治进展[J].安徽医学,2014,35(4):538-540.
[10]ZHUANG L Y,XU Z Q,LI Y G,et al.Extrapontine myelinolysis associated with pituitrin:case report and literature review[J].BMC Neurology,2014,14:189.
[11]XU D H,YUAN M,WANG J W,et al.Osmotic demyelination syndrome after correction of severe hyponatremia associated with pituitrin[J].2015,53(5):408-411.
[12]贾建平.神经病学[M].6版.北京:人民卫生出版社,2008:270-271.
[13]李小鹰.老年患者低钠血症的诊治中国专家建议[J].中华老年医学杂志,2016,35(8):795-802.
[14]SPASOVSKI G,VANHOLDER,BRUNO,et al.Clinical practice guideline on diagnosis and treatment of hyponatraemia[J].Eur J Endocrin,2014,170:G26-G39.
[15]BALLS G,BSC P H D,IQBAL Z,et al.Diagnosis and treatment of hyponatraemia[J].Best Prac Res Clin Endocrin Metab,2016,30:161-173.
[16]梁颖,米玉红,刘双.垂体后叶素对咯血患者血钠影响的临床分析[J].药物不良反应杂志,2010,12(6):393-395.
[2]金淑萍,高永丽,李成建.多索茶碱不良反应文献概述[J].中国药物滥用防治杂志,2015,21(6):362-363.
[3]赵莹,李国军,李成建.美洛西林钠/舒巴坦钠不良反应文献概述[J].中国药物滥用防治杂志,2015,21(1):50,62.
[4]Vasostric(vasopressin injection,USP)for intravenous infusion,FDA,2014.
[5]陈宇星,冯淑玲,孙红.垂体后叶素的不良反应与安全应用[J].福建医药杂志,2008,30(2):121-123.
[6]XU T T,LI J,FENG J C,et al.A rare case of pituitrininduced delayed encephalopathy[J].Pak J Med Sci,2014,30(5):1141-1142.
[7]江苔,杨仁辉,冯元凤,等.垂体后叶素治疗大咯血致电解质紊乱20例临床分析[J].中国实用内科杂志,2015,35(S1):44-45.
[8]陈江声,杨燕娇.小剂量与大剂量垂体后叶素对大咯血的疗效及副作用比较[J].实用医学杂志,2007,23(1):99-100.
[9]叶婷婷,王长江.低钠血症的诊治进展[J].安徽医学,2014,35(4):538-540.
[10]ZHUANG L Y,XU Z Q,LI Y G,et al.Extrapontine myelinolysis associated with pituitrin:case report and literature review[J].BMC Neurology,2014,14:189.
[11]XU D H,YUAN M,WANG J W,et al.Osmotic demyelination syndrome after correction of severe hyponatremia associated with pituitrin[J].2015,53(5):408-411.
[12]贾建平.神经病学[M].6版.北京:人民卫生出版社,2008:270-271.
[13]李小鹰.老年患者低钠血症的诊治中国专家建议[J].中华老年医学杂志,2016,35(8):795-802.
[14]SPASOVSKI G,VANHOLDER,BRUNO,et al.Clinical practice guideline on diagnosis and treatment of hyponatraemia[J].Eur J Endocrin,2014,170:G26-G39.
[15]BALLS G,BSC P H D,IQBAL Z,et al.Diagnosis and treatment of hyponatraemia[J].Best Prac Res Clin Endocrin Metab,2016,30:161-173.
[16]梁颖,米玉红,刘双.垂体后叶素对咯血患者血钠影响的临床分析[J].药物不良反应杂志,2010,12(6):393-395.