自噬相关基因与结肠癌耐药性的研究进展
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摘要
自噬是生命体中一种普遍而又重要的代谢方式,主要存在于真核细胞中。自噬形式的细胞死亡不同于凋亡,凋亡通常被称为第一类的细胞程序性死亡,自噬则常常被称为第二类的细胞程序性死亡。随着近年来有关于结肠癌耐药性的相关研究越来越多,已经有非常多的凭证显示结肠癌耐药性的发生发展,在基因水平上与自噬有着一定的相关关系。而其中的一些自噬基因扮演着举足轻重的角色,占据着重要的决定性位置,它们存在于自噬发生发展的每一个环节,亦或是大部分环节,从而改变着结肠癌耐药性的进展与发生。所以下面将随结肠癌耐药性与自噬的关系的研究进展做一综合论述。
Autophagy is a common and important metabolic method in living organisms, mainly in eukaryotic cells. Autophagy cell death is different from apoptosis. Apoptosis is called the first type of programmed cell death, and autophagy is called the second type of programmed cell death.As more and more studies on the drug resistance of colon cancer have been reported, there is increasing evidence that the development of colon cancer resistance has a certain relationship with autophagy.Some of these autophagy genes play a significant role in the development of autophagy, which changes the progression of resistance to colon cancer.So the following will be a comprehensive discussion on the development of the relationship between drug resistance and autophagy in colon cancer.
Autophagy is a common and important metabolic method in living organisms, mainly in eukaryotic cells. Autophagy cell death is different from apoptosis. Apoptosis is called the first type of programmed cell death, and autophagy is called the second type of programmed cell death.As more and more studies on the drug resistance of colon cancer have been reported, there is increasing evidence that the development of colon cancer resistance has a certain relationship with autophagy.Some of these autophagy genes play a significant role in the development of autophagy, which changes the progression of resistance to colon cancer.So the following will be a comprehensive discussion on the development of the relationship between drug resistance and autophagy in colon cancer.
引文
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[2]Neerati P,Sudhakar YA,Kanwar JR.Curcumin regu-lates colon cancer by inhibiting P-glycoprotein in in-situcancerous colon perfusion rat model[J].J Cancer Sci Ther,2013,5:313-319.
[3]Deng Q,Li ZP,Huang CM,et al.Effect and mecha-nism of DNMT inhibitor on the reversal of multidrug re-sistance in human colon cancer cell line sw620/L-OHP[J].Sichuan Da Xue Xue Bao Yi Xue Ban,2010,41:975-979.
[4]Mo W,Zhang JT.Human ABCG2:structure,function,and its role in multidrug resistance[J].Int J Biochem Mol Biol,2012,3:1-27.
[5]Sevim H,Parkinson JF,Mc Donald KL.Etoposide-me-diated glioblastoma cell death:dependent or independ-ent on the expression of its target,topoisomerase II al-pha?[J].J Cancer Res Clin Oncol,2011,137:1705-1712.
[6]Jankova L,Robertson G,Chan C,et al.Glutathione S-transferase Pi expression predicts response to adjuvantchemotherapy for stage C colon cancer:a matched his-torical control study[J].BMC Cancer,2012,12:196.
[7]Song M,Zang W,Zhang B,et al.GCS overexpressionis associated with multidrug resistance of human HCT-8colon cancer cells[J].J Exp Clin Cancer Res,2012,31:23.
[8]隋华,周利红,刘宣,等.COX-2介导MDR1-P-gp调控人结肠癌细胞多药耐药的研究[J].中国癌症杂志,2011,21:241-246.
[9]Lo YL,Ho CT,Tsai FL.Inhibit multidrug resistanceand induce apoptosis by using glycocholic acid and epi-rubicin[J].Eur J Pharm Sci,2008,35:52-67.
[10]Hadnagy A,Gaboury L,Beaulieu R,et al.SP analysismay be used to identify cancer stem cell populations[J].Exp Cell Res,2006,312:3701-3710.
[11]王怡,张姣姣,杨炜蓉,等.哺乳动物雷帕霉素靶蛋白(m TOR)信号通路与生理功能的调节研究进展[J].中国畜牧兽医,2012,39(4):113-118.
[12]古春萍.自噬介导人食管癌细胞对顺铂耐药的作用及其机制研究[D].南方医科大学,2014.
[13]Maria MC,Galluzzi L,Morselli E,et al.Autophagy regulation by p53[J].Curr Opin Cell Biol,2010,22(2):181-185.
[14]赵金香,张强,李耀华.肿瘤抑制基因p53与自噬[J].Modern Oncology,2011,19(9):1896-1899.
[15]Lorin S,Pierron G,Ryan KM,et al.Evidence for the interplay between JNK and p53-DRAM signalling pathways in the regulation of autophagy[J].Autophagy,2010,6(1):153-154.
[16]孔娜.JNK介导的保护性自噬促进了p53-/-或p53突变型结肠癌细胞对5-FU的耐药[D].浙江大学,2014.
[17]Panklv S,Clausen TH,Lamark T,et al.P62/SQSTMI binds direcily to Aigs/LC3 tofacilitate degradation of ubiquitinated Protein aggregates by autophagy[J].J Biol Chem,2007,282(33):24131-24145.
[18]Sudharsan Periyasamy-Thandavan,Man Jiang,Qingqing Wei,et al.Autophagy is cytoprotective during cisplatin injury of renal proximal tubular cells[J].Kidney Int,2008,74(5):631-40.
[19]苏建伟,蒋旗,黄桂柳,等.苦参碱对结肠癌耐药细胞化疗药物敏感性及自噬水平的影响[J].右江医学,2016,44(6):610-613.