柴胡皂苷a抗抑郁作用机制的研究进展
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摘要
抑郁症是一种常见的精神类疾病,发病率高、致死率高,严重影响人类身体健康。柴胡具有疏肝解郁之功效,临床上多用其复方制剂治疗抑郁症。近年来发现,柴胡中的柴胡皂苷a具有潜在的抗抑郁作用,能通过调节炎症因子及相关通路,增强神经营养因子表达,改善神经递质水平及神经元细胞凋亡,下调下丘脑–垂体–肾上腺(HPA)轴功能发挥抗抑郁作用。主要对柴胡皂苷a的抗抑郁作用机制进行综述,便于为药物研发和抑郁症的研究提供思路。
Depression is a common mental disease with high morbidity and mortality, which seriously affects human health.Bupleurum has the effect of soothing the liver and relieving depression, and treating depression with its compound preparation in clinic.In recent years, it has been found that saikosaponin a in Bupleurum has a potential antidepressant effect, which can enhance the expression of neurotrophic factors, improve the level of neurotransmitters and neuronal apoptosis by regulating inflammatory factors and related pathways and down-regulation of hypothalamus-pituitary-adrenal(HPA) axis function. In this paper, the antidepressant mechanism of saikosaponin a is reviewed, in order to provide ideas for drug development and depression research.
Depression is a common mental disease with high morbidity and mortality, which seriously affects human health.Bupleurum has the effect of soothing the liver and relieving depression, and treating depression with its compound preparation in clinic.In recent years, it has been found that saikosaponin a in Bupleurum has a potential antidepressant effect, which can enhance the expression of neurotrophic factors, improve the level of neurotransmitters and neuronal apoptosis by regulating inflammatory factors and related pathways and down-regulation of hypothalamus-pituitary-adrenal(HPA) axis function. In this paper, the antidepressant mechanism of saikosaponin a is reviewed, in order to provide ideas for drug development and depression research.
引文
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[26]张列亮,应俊,华福洲,等.柴胡皂苷A通过cAMP/CREB信号通路对脑损伤大鼠认知功能的影响[J].临床麻醉学杂志,2016,32(5):484-487.
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[29]戈宏焱,陈博,许丹,等.柴胡皂苷A对抑郁模型大鼠脑中单胺类神经递质及其代谢产物含量的影响[J].高等学校化学学报,2008,29(8):1535-1538.
[30]Gao W,Bi Y,Ding L,et al.SSa ameliorates the Glu uptaking capacity of astrocytes in epilepsy via AP-1/miR-155/GLAST[J].Biochem Biophys Res Commun,2017,493(3):1329-1335.
[31]Gold P W.The organization of the stress system and its dysregulation in depressive illness[J].Mol Psychiatry,2015,20(1):32-47.
[32]徐丽丽,张兰,马秀云,等.抑郁症神经内分泌及细胞因子的研究进展[J].中国医学创新,2016,13(34):138-141.
[2]郑瑀,许琳洁,许凤全.更年期抑郁妇女心理特征研究进展[J].医学综述,2016,22(16):3199-3201.
[3]刘超.柴胡舒肝散联合西药治疗抑郁症患者疗效及对炎症因子、5-HT的影响[J].陕西中医,2017,38(7):873-874.
[4]张颖,陈宇霞,黄世敬.柴胡及柴胡类复方的抗抑郁研究现状[J].世界中西医结合杂志,2014,9(9):985-988.
[5]史群云,高丽丽.柴胡的研究现状[J].中国医药导报,2009,6(3):158-159.
[6]Strenn N,Suchankova P,Nilsson S,et al.Expression of inflammatory markers in a genetic rodent model of depression[J].Behav Brain Res,2015,281:348-357.
[7]Lu C N,Yuan Z G,Zhang X L,et al.Saikosaponin a and its epimer saikosaponin d exhibit anti-inflammatory activity by suppressing activation of NF-kappa B signaling pathway[J].Int Immunopharmacol,2012,14(1):121-126.
[8]杨英杰,刘茂航,游芳馨,等.前炎性细胞因子在抑郁症中的作用[J].医学综述,2017,23(22):4393-4396.
[9]徐说,林文娟.抗炎性细胞因子与抑郁症[J].生物化学与生物物理进展,2014,41(11):1099-1108.
[10]Chen X Q,Chen S J,Liang W N,et al.Saikosaponin Aattenuates perimenopausal depression-like symptoms by chronic unpredictable mild stress[J].Neurosci Lett,2018,662:283-289.
[11]茆翔,朱振丹,郝淑煜,等.柴胡皂苷a对创伤性脑水肿的保护作用[J].中国医刊,2014,49(7):65-67.
[12]Han N R,Kim H M,Jeong H J.Inactivation of cysteinaspartic acid protease(caspase)-1 by saikosaponin A[J].Biol Pharm Bull,2011,34(6):817-823.
[13]朱双龙,陈旭义,段会全,等.柴胡皂苷a影响大鼠急性脊髓损伤后机体炎症水平表达的实验研究[J].天津医科大学学报,2017,23(4):300-303.
[14]Zhu J,Luo C,Wang P,et al.Saikosaponin A mediates the inflammatory response by inhibiting the MAPK and NF-kappa B pathways in LPS-stimulated RAW 264.7 cells[J].Exp Ther Med,2013,5(5):1345-1350.
[15]Surh Y J,Chun K S,Cha H H,et al.Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals:down-regulation of COX-2 and iNOS through suppression of NF-kappa Bactivation[J].Mutat Res,2001(480/481):243-268.
[16]朱琳琳.柴胡皂苷a对IL-1β刺激神经元样PC12细胞的干预作用及机制研究[D].广州:南方医科大学,2009.
[17]Fu Y,Hu X,Cao Y,et al.Saikosaponin a inhibits lipopolysaccharide-oxidative stress and inflammation in Human umbilical vein endothelial cells via preventing TLR4 translocation into lipid rafts[J].Free Radic Biol Med,2015,89:777-785.
[18]Kim S O,Park J Y,Jeon S Y,et al.Saikosaponin a,an active compound of Radix Bupleuri,attenuates inflammation in hypertrophied 3T3-L1 adipocytes via ERK/NF-kappaBsignaling pathways[J].Int J Mol Med,2015,35(4):1126-1132.
[19]Zhou X,Cheng H,Xu D,et al.Attenuation of neuropathic pain by saikosaponin a in a rat model of chronic constriction injury[J].Neurochem Res,2014,39(11):2136-2142.
[20]Zhou C,Liu W,He W,et al.Saikosaponin a inhibits RANKL-induced osteoclastogenesis by suppressing NF-kappa B and MAPK pathways[J].Int Immunopharmacol,2015,25(1):49-54.
[21]Wu W S.ERK signaling pathway is involved in p15INK4b/p16INK4a expression and HepG2 growth inhibition triggered by TPA and Saikosaponin a[J].Oncogene,2003,22(7):955-963.
[22]Mao X,Miao G,Tao X,et al.Saikosaponin a protects TBIrats after controlled cortical impact and the underlying mechanism[J].Am J Transl Res,2016,8(1):133-141.
[23]王丹.海马及相关神经递质对抑郁症发病机制的影响[J].西安文理学院学报:自然科学版,2011,14(2):9-13.
[24]Sun J C,Han X M,Ren X G,et al.Saikosaponin Aalleviates symptoms of attention deficit hyperactivity disorder through downregulation of DAT and enhancing BDNF expression in spontaneous hypertensive rats[J].Evid Based Complement Alternat Med,2017,2017:2695903.
[25]董海影,张静艳,柏青杨,等.柴胡皂苷A对抑郁模型大鼠海马神经细胞凋亡的保护作用[J].中国老年学杂志,2015,35(7):1935-1937.
[26]张列亮,应俊,华福洲,等.柴胡皂苷A通过cAMP/CREB信号通路对脑损伤大鼠认知功能的影响[J].临床麻醉学杂志,2016,32(5):484-487.
[27]任伟光,黄世敬,吴玉林,等.中药基于调节神经递质的抗抑郁作用机制研究进展[J].世界科学技术:中医药现代化,2017,19(11):1861-1867.
[28]宁艳梅,杨秀娟,杨韬.甘肃产柴胡柴胡皂苷a含量测定及抗抑郁作用评价[J].中兽医医药杂志,2014,33(6):34-37.
[29]戈宏焱,陈博,许丹,等.柴胡皂苷A对抑郁模型大鼠脑中单胺类神经递质及其代谢产物含量的影响[J].高等学校化学学报,2008,29(8):1535-1538.
[30]Gao W,Bi Y,Ding L,et al.SSa ameliorates the Glu uptaking capacity of astrocytes in epilepsy via AP-1/miR-155/GLAST[J].Biochem Biophys Res Commun,2017,493(3):1329-1335.
[31]Gold P W.The organization of the stress system and its dysregulation in depressive illness[J].Mol Psychiatry,2015,20(1):32-47.
[32]徐丽丽,张兰,马秀云,等.抑郁症神经内分泌及细胞因子的研究进展[J].中国医学创新,2016,13(34):138-141.