肿瘤及肿瘤基质细胞释放的外泌体对肿瘤耐药产生的影响
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摘要
恶性肿瘤疾病对人类生命健康的影响程度日益升高,不仅早期筛查诊断难度较高,并且治疗预后效果往往较差。目前,国内外临床均将化疗作为患者的主要治疗手段,但治疗过程中不断出现的药物耐药问题对患者及医务人员均造成了严重困扰。国外研究已对肿瘤耐药与外泌体进行了相关研究,认为该物质对耐药传递形成了重要影响,其外泌体中可携带耐药相关分子不断在肿瘤细胞中进行传递与作用,并且能够外排相关介导药物,通过对其实施处理可为逆转耐药起到积极作用。
Malignant tumor diseases have an increasingly high impact on human life and health. It is not only difficult for early screening and diagnosis, but also has a poor prognosis. At present, chemotherapy is regarded as the main treatment method for patients at home and abroadin clinical practice, but the continuous drug resistance problems in the treatment process have caused serious problems for patients and medical personnel. Study abroad has secrete body outside the tumor drug resistance and the related research, thinks that the material has important influence on the formation resistance pass, outside the secrete in the body can carry drug-resistant related molecules passing through continuously in tumor cells and function, and can be related mediated drug efflux, through to its implementation process can be reversed resistance play a positive role.
Malignant tumor diseases have an increasingly high impact on human life and health. It is not only difficult for early screening and diagnosis, but also has a poor prognosis. At present, chemotherapy is regarded as the main treatment method for patients at home and abroadin clinical practice, but the continuous drug resistance problems in the treatment process have caused serious problems for patients and medical personnel. Study abroad has secrete body outside the tumor drug resistance and the related research, thinks that the material has important influence on the formation resistance pass, outside the secrete in the body can carry drug-resistant related molecules passing through continuously in tumor cells and function, and can be related mediated drug efflux, through to its implementation process can be reversed resistance play a positive role.
引文
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[2]陈啟学,毕雨阳.论外泌体在肿瘤发生发展过程中的作用[J].世界最新医学信息文摘,2016,16(61):60-62.
[3]李栋,胡媛,吴安玥,等.TWEAK调控巨噬细胞外泌体中miRNA-7的表达抑制卵巢癌细胞侵袭和迁移的研究[J].上海交通大学学报,2017,37(6):726-731.
[4]颜晓慧,安泰学,覃思华,等.血清外泌体miR-21在肺癌中的表达水平及其诊断效能[J].实用医学杂志,2017,33(16):2666-2669.
[5]吴凡,孙家明.脂肪干细胞来源的外泌体对三阴乳腺癌细胞生物学行为的影响[J].中华整形外科杂志,2017,33(S1):121-126.
[6]许乘凤,杨振林,花义同,等.外泌体在体外对乳腺癌细胞耐药信息传递的作用[J].西安交通大学学报,2017,38(2):193-198.
[7]张扬,范小乐,陈和平,等.外泌体在胃癌中的研究进展[J].医学研究生学报,2017,30(10):1096-1099.
[8]Yumi Kinugasa,Takahiro Matsui,Nobuyuki Takakura.CD44expressed oncancer-associated fibroblasts is a functional molecule supporting thestemness and drug resistance of malignant cancer cells in the tumor microenvironment[J].Stem Cells,2014,32(1):145-156.
[9]郑田玉,杜君,陈宁,等.外泌体及其在肿瘤诊疗中的作用[J].上海交通大学学报,2017,37(7):1046-1050.
[10]Tanaka K,Miyata H,Sugimura K,et al.miR-27 is associatedwith chemoresistance in esophageal cancer through transformationof normal fibroblasts to cancer-associated fibroblasts[J].Carcinogenesis,2015,36(8):894-903.
[11]金玲玲,王晓林,曹仕琼.外泌体与胰腺癌化疗耐药的研究进展[J].实用医学杂志,2018,34(5):860-863.
[12]张倩倩,狄翠霞,陈玉红,等.外泌体在肿瘤细胞及其临床应用中的研究进展[J].现代肿瘤医学,2018,26(6):945-950.