HP、COX-2的相关性及与胃癌前病变的关系的研究进展
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摘要
胃癌是世界第二常见癌,且胃癌的发病率居于各种癌症的第一位,因而对于胃癌的防治成为全球医疗机构的重要工作,胃癌的发生是一个多因素、多步骤的发展过程,期间经历多次细胞转化的过程,众所周知:胃癌早期发现并及时治疗,5年存活率可达60-80%以上,所以,研究胃组织癌变过程中的多种因素已成为全球的研究热点,其中幽门螺杆菌(HP)感染并启动环氧化酶-2(COX-2)的变异又是研究热点之一。
Gastric cancer is the second most common cancer across the world, and incidence of gastric cancer ranks first among all kinds of cancers. Therefore, prevention and treatment of gastric cancer has become an important work of the global medical institutions. Occurrence of gastric cancer is a multi-factor and multi-step process of development, which undergoes many cell transformations. It is well known, early detection and timely treatment of gastric cancer can have 5-year survival rate of 60-80%. Therefore, various factors study during gastric canceration process has become a global research hotspot, among which helicobacter pylori(HP) infection and activation of cyclooxygenase-2(COX-2) mutation is one of the hotspots.
Gastric cancer is the second most common cancer across the world, and incidence of gastric cancer ranks first among all kinds of cancers. Therefore, prevention and treatment of gastric cancer has become an important work of the global medical institutions. Occurrence of gastric cancer is a multi-factor and multi-step process of development, which undergoes many cell transformations. It is well known, early detection and timely treatment of gastric cancer can have 5-year survival rate of 60-80%. Therefore, various factors study during gastric canceration process has become a global research hotspot, among which helicobacter pylori(HP) infection and activation of cyclooxygenase-2(COX-2) mutation is one of the hotspots.
引文
[1]陶梅,张玲霞,宋英,等.陕西地区环氧化酶-2基因的多态性、螺杆菌感染与胃癌易感性的关系[J].山西医科大学学报,2015,46(1):17-20.
[2]王云龙,陈分,徐艳琴,等.细胞毒素相关蛋白A阳性幽门螺杆菌感染与胃癌的相关性及对生长抑素、核因子κB和环氧合酶2的影响[J].中华医院感染学杂志,2017,27(1):501-504.
[3]张志,王宏戈,宋文广,等.环氧化酶.2启动子变异与幽门螺杆菌感染交互和食管癌发病风险的关系[J].中国综合临床,2011,27(7):751-753.
[4]刘霖.人胃癌相关抗原MG7与COX-2在胃癌前病变组织中的表达及应用价值[D].西安:中国人民解放军第四军医大学,2009.
[5]徐朝久.环氧化酶与肿瘤关系的研究进展[J].肿瘤医学杂志,2002,7(2):148-150.
[6]路敏敏,刘京运,金世禄,等.胃癌及癌前病变黏膜组织中环氧化酶-2、p53的表达及其与幽门螺杆菌感染的相关[J].北京医学院学报,2016,31(3):410-412.
[7]刘丹丹,江培.COX-2及COX-2抑制剂对肿瘤防治作用的研究进展[J].黑龙江医药,2014,26(1):984-986.
[8]谷化平,尚培中.COX一2和survivin蛋白表达与老年胃癌转移和预后的关系[J].国际肿瘤学杂志,2012,39(5):387-389.
[9]陈美霓,郭浩,郭巍,等.COX-2蛋白和VEGF-C蛋白在胃癌和非胃癌黏膜病变组织中的表达及临床意义[J].海南医学,2015,26(18):2671-2674.
[10]朱日,骆俊,朱长乐,等.慢性萎缩性胃炎伴肠化中医证型与Hp感染、COX-2、p53表达的相关性研究[J].南京中医药大学学报,2014,30(6):520-523.
[11]孟勇,汪涛.同源转录因子2、环氧合酶-2及核因子-κB对胃癌患者病情进展的预测价值[J]新乡医学院学报,2016,33(1):37-40.
[12]白龙,侯培珍,侯先文,等.环氧合酶一2、基质金属蛋白酶一9和核增殖抗原在胃癌组织中的表达及临床意义[J].中华消化杂志,2009,29(3):183-185.
[13]朱艳丽,张天英,张雪梅,等.COX-2和C-myc在胃癌发生发展中的表达及其相关性研究[J].齐齐哈尔医学院学报,2016,37(27):3375-3377.
[2]王云龙,陈分,徐艳琴,等.细胞毒素相关蛋白A阳性幽门螺杆菌感染与胃癌的相关性及对生长抑素、核因子κB和环氧合酶2的影响[J].中华医院感染学杂志,2017,27(1):501-504.
[3]张志,王宏戈,宋文广,等.环氧化酶.2启动子变异与幽门螺杆菌感染交互和食管癌发病风险的关系[J].中国综合临床,2011,27(7):751-753.
[4]刘霖.人胃癌相关抗原MG7与COX-2在胃癌前病变组织中的表达及应用价值[D].西安:中国人民解放军第四军医大学,2009.
[5]徐朝久.环氧化酶与肿瘤关系的研究进展[J].肿瘤医学杂志,2002,7(2):148-150.
[6]路敏敏,刘京运,金世禄,等.胃癌及癌前病变黏膜组织中环氧化酶-2、p53的表达及其与幽门螺杆菌感染的相关[J].北京医学院学报,2016,31(3):410-412.
[7]刘丹丹,江培.COX-2及COX-2抑制剂对肿瘤防治作用的研究进展[J].黑龙江医药,2014,26(1):984-986.
[8]谷化平,尚培中.COX一2和survivin蛋白表达与老年胃癌转移和预后的关系[J].国际肿瘤学杂志,2012,39(5):387-389.
[9]陈美霓,郭浩,郭巍,等.COX-2蛋白和VEGF-C蛋白在胃癌和非胃癌黏膜病变组织中的表达及临床意义[J].海南医学,2015,26(18):2671-2674.
[10]朱日,骆俊,朱长乐,等.慢性萎缩性胃炎伴肠化中医证型与Hp感染、COX-2、p53表达的相关性研究[J].南京中医药大学学报,2014,30(6):520-523.
[11]孟勇,汪涛.同源转录因子2、环氧合酶-2及核因子-κB对胃癌患者病情进展的预测价值[J]新乡医学院学报,2016,33(1):37-40.
[12]白龙,侯培珍,侯先文,等.环氧合酶一2、基质金属蛋白酶一9和核增殖抗原在胃癌组织中的表达及临床意义[J].中华消化杂志,2009,29(3):183-185.
[13]朱艳丽,张天英,张雪梅,等.COX-2和C-myc在胃癌发生发展中的表达及其相关性研究[J].齐齐哈尔医学院学报,2016,37(27):3375-3377.