摘要
<正>细胞死亡无论在生理还是在病理条件下都是无法避免的重要环节。传统意义上细胞死亡主要分为凋亡(apoptosis)和坏死(necrosis)两大主要类型,但近年来却发现在诸多病理生理情况下亦有自噬(autophagy)、胀亡(oncosis)、副凋亡(paraptosis)、焦亡(pyroptosis)等多种方式参与其中。越来越多细胞死亡方式的发现为进一步明确疾病的发生机制以及为
With the development of modern medical research,it has been found that there are many forms of cell death under lots of physiological or pathological conditions. Among them,necrosis and apoptosis are the 2 main forms of cell death. In recent years,varieties of new cell death patterns,such as autophagy,oncosis and paraptosis,have been discovered. In 2012,Dixon et al first discovered and reported a new form of iron-dependent cell death,ferroptosis. In this review,we try to expound the morphological and biochemical features of ferroptosis and its related diseases in detail,so as to deepen our understanding of cell death,thus providing new ideas for the prevention and treatment of clinically relevant diseases.
引文
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