细胞焦亡与感染性疾病研究进展
摘要
<正>细胞死亡是机体清除内源性和外源性伤害刺激的重要机制,是机体免疫应答的重要组成部分。随着研究的深入,坏死、凋亡、胀亡、自噬、焦亡等细胞死亡方式逐渐被人们发现。细胞焦亡是近年来新发现的一种新的细胞程序性死亡方式,由半胱氨酸蛋白酶
引文
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[2] SHI J,GAO W,SHAO F.Pyroptosis:gasdermin-mediated programmed necrotic cell death[J].Trends Biochem Sci,2017,42(4):245-254.
[3] YAZDI A S,GUARDA G,D′OMBRAIN M C,et al.Inflammatory caspases in innate immunity and inflammation[J].J Innate Immun,2010,2(3):228-237.
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[5] VON MOLTKE J,AYRES J S,KOFOED E M,et al.Recognition of bacteria by inflammasomes[J].Annu Rev Immunol,2013,31(1):73-106.
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[7] WREE A,MCGEOUGH M D,INZAUGARAT M E,et al.NLRP3inflammasome driven liver injury and fibrosis:Roles of IL-17and TNF in mice[J].Hepatology,2017,13(9):29523-29536.
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[11]SHI J,ZHAO Y,WANG K,et al.Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death[J].Nature,2015,526(7575):660-665.
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[14]XU H,YANG J,GAO W,et al.Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome[J].Nature,2014,513(7517):237-241.
[15]KAYAGAKI N,STOWE I B,LEE B L,et al.Caspase-11cleaves gasdermin D for non-canonical inflammasome signalling[J].Nature,2015,526(7575):666-671.
[16]KAYAGAKI N,WARMING S,LAMKANFI M,et al.Non-canonical inflammasome activation targets caspase-11[J].Nature,2011,479(7371):117-121.
[17]YANG D,HE Y,MUNOZ-PLANILLO R,et al.Caspase-11requires the pannexin-1channel and the purinergic P2X7pore to mediate pyroptosis and endotoxic shock[J].Immunity,2015,43(5):923-932.
[18]LAMKANFI M,DIXIT V M.Mechanisms and functions of inflammasomes[J].Cell,2014,157(5):1013-1022.
[19]LIU X,ZHANG Z,RUAN J,et al.Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores[J].Nature,2016,535(7610):153-158.
[20]MALTEZ V I,TUBBS A L,COOK K D,et al.Inflammasomes coordinate pyroptosis and natural killer cell cytotoxicity to clear infection by a ubiquitous environmental bacterium[J].Immunity,2015,43(5):987-997.
[21]WANG J,REN H,YUAN X,et al.Interleukin-10secreted by mesenchymal stem cells attenuates acute liver failure through inhibiting pyroptosis[J].Hepatol Res,2018,48(3):194-202.
[22]DOITSH G,GALLOWAY N L,GENG X,et al.Cell death by pyroptosis drives CD4T-cell depletion in HIV-1infection[J].Nature,2014,505(7484):509-514.
[23]MONROE K M,YANG Z,JOHNSON J R,et al.IFI16DNA sensor is required for death of lymphoid CD4 T cells abortively infected with HIV[J].Science,2014,343(6169):428-432.
[24]MORRONE S R,WANG T,CONSTANTOULAKIS L M,et al.Cooperative assembly of IFI16filaments on dsDNA provides insights into host defense strategy[J].Proc Nati Acade Sci U S A,2014,111(1):E62-71.
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[26]WANG Y,GAO W,SHI X,et al.Chemotherapy drugs induce pyroptosis through caspase-3cleavage of a gasdermin[J].Nature,2017,547(7661):99-103.