埃索美拉唑联合胃力康颗粒对胃食管反流的临床疗效及其对患者促甲状腺激素、胃蛋白酶原水平的影响
|
摘要
目的:探讨埃索美拉唑联合胃力康颗粒对胃食管反流的临床疗效及其对患者促甲状腺激素、胃蛋白酶原水平的影响。方法:选取我院老年病科诊断为胃食管反流患者70例,按随机数字表法平均分为两组,对照组35例予以胃力康颗粒治疗,观察组35例在对症治疗基础上联合埃索美拉唑治疗,测定并记录两组治疗前后血清促甲状腺激素(TSH)、胃蛋白酶原(PGⅠ、Ⅱ)水平、反流症状评分,治疗后临床疗效及不良反应的发生情况。结果:观察组治疗有效率显著高于对照组,差异具有统计学意义(P<0.05)。与对照组比较,观察组治疗后促甲状腺激素水平较高,PGⅠ水平较高,PGⅡ水平较低,反流症状评分水平较低,差异具有统计学意义(P<0.05)。结论:埃索美拉唑联合胃力康颗粒治疗胃食管反流的临床效果显著,且能升高促甲状腺激素及PGⅠ水平,降低PGⅡ水平。
Objective: To investigate the effects of esomeprazole combined with wilikang granules on serum levels of TSH and pepsinogen in patients with gastroesophageal reflux and its clinical efficacy. Methods: 70 patients with gastroesophageal reflux who were treated in our hospital were selected and randomly divided into two groups, with 35 cases in each group. The patients in the control group were treated with wilikang granules, while the patients in the experiment group were treated with esomeprazole on the basis of symptomatic treatment. Then the serum levels of thyroid stimulating hormone(TSH) and pepsinogen(PG Ⅰ and PG Ⅱ), and the reflux symptoms score, the clinical efficacy and adverse reactions in the two groups were observed and compared. Results: The effective rate in the experiment group was higher than that of the control group, and the difference was statistically significant(P<0.05); Compared with the control group, the levels of thyroid stimulating hormone and PG I in the experiment group were higher, while the levels of PGⅡ and reflux symptoms score were lower, and the differences were statistically significant(P<0.05). Conclusion: Esomeprazole combined with weilikang granules have better effects on the treatment of gastroesophageal reflux, which can increase the thyroid stimulating hormone and PG I levels, and reduce PG Ⅱ.
Objective: To investigate the effects of esomeprazole combined with wilikang granules on serum levels of TSH and pepsinogen in patients with gastroesophageal reflux and its clinical efficacy. Methods: 70 patients with gastroesophageal reflux who were treated in our hospital were selected and randomly divided into two groups, with 35 cases in each group. The patients in the control group were treated with wilikang granules, while the patients in the experiment group were treated with esomeprazole on the basis of symptomatic treatment. Then the serum levels of thyroid stimulating hormone(TSH) and pepsinogen(PG Ⅰ and PG Ⅱ), and the reflux symptoms score, the clinical efficacy and adverse reactions in the two groups were observed and compared. Results: The effective rate in the experiment group was higher than that of the control group, and the difference was statistically significant(P<0.05); Compared with the control group, the levels of thyroid stimulating hormone and PG I in the experiment group were higher, while the levels of PGⅡ and reflux symptoms score were lower, and the differences were statistically significant(P<0.05). Conclusion: Esomeprazole combined with weilikang granules have better effects on the treatment of gastroesophageal reflux, which can increase the thyroid stimulating hormone and PG I levels, and reduce PG Ⅱ.
引文
[1]Cui L,Chao L,Wang X,et al.The therapeutic effect of high-dose esomeprazole on stress ulcer bleeding in trauma patients[J].Chinese Journal of Traumatology,2015,18(1):41-43
[2]Yan Xue,Li-Ya Zhou,San-Ren Lin,et al.Effect of Helicobacterpylori Eradicationon Reflux Esophagitis Therapy:AMulti-center Randomized Control Study[J].Chin Med J(Engl),2015,128(8):995-999
[3]Kawami N,Lwakiri K,Sano H,et al.Effects of aging and acid reflux on esophageal motility[J].Digestion,2015,91(3):181-186
[4]Lee H S,Kang D I,Yoon S Z,et al.Evidence for novel age-dependent network structures as a putative primo vascular network in the dura mater of the rat brain[J].Neural Regeneration Research,2015,10(7):1101-1106
[5]Hanada K,Adachi K,Mishiro T,et al.Relationship between esophageal cardiac glands and gastroesophageal reflux disease[J].Intern Med,2015,54(2):91-96
[6]Nian Y Y,Feng C,Jing F C,et al.Reflux characteristics of 113 GERD patients with abnormal 24-h multichannel intraluminal impedance-p H tests[J].Journal of Zhejiang University(science.b),2015,16(9):805-810
[7]Wang RH.From reflux esophagitis to Barrett's esophagus and esophageal adenocarcinoma[J].World J Gastroenterol,2015,21(17):5210-5219
[8]АСТрухманов,ИВ Маев.Условный рефлекс и квантово-подобное поведение[J].Acta Mechanica Sinica,2014,85(24):24-55
[9]Nho K J,Chun J M,Kim D S,et al.D08.811.277.656.300.480.205.360[Categoria De CS][J].Chinese Journal of Polymer Science,2014,936(7):176-180
[10]Yue Q,Ye J Y,Han D M,et al.Esophageal Functional Changes in Obstructive Sleep Apnea/Hypopnea Syndrome and Their Impact on Laryngopharyngeal Reflux Disease[J].Chin Med J(Engl),2015,128(16):2162-2167
[11]Honda M,Hiki N,Nunobe S,et al.Preoperative vs Postoperative Eradication of Helicobacter pylori in 150 Patients with Gastric Cancer:A Randomized Controlled Trial[J].J Am Coll Surg,2015,221(2):273-279
[12]Yang C X,Huang X P,Lin J S,et al.Manufacture and Quality Control of Follicle Stimulating Hormone Products[J].Journal of Chinese Pharmaceutical Sciences,2014,49(7):529-533
[13]Teng M,Khoo AL,Zhao YJ,et al.Meta-analysis of the effectiveness of esomeprazole in gastroesophageal reflux disease and Helicobacter pylori infection[J].J Clin Pharm Ther,2015,20(4):209-221
[14]Orbelo DM,Enders FT,Romero Y,et al.Once-daily omeprazole/sodium bicarbonate heals severe refractory reflux esophagitis with morning or nighttime dosing[J].Dig Dis Sci,2015,60(1):146-162
[15]Sandip,Sabale,Vishwajeet.Synthesis and Properties of Monodisperse Superparamagnetic Mg_(0.8)Mn_(0.2)Fe_2O_4 Nanoparticles Using Polyol Reflux Method[J].Acta Metallurgica Sinica,2014,27(6):1122-1126
[16]Feng Y,Pan J,Liu H,et al.An acetic acid refluxing-electrochemistry combined strategy to activate supported-platinum electrocatalysts[J].Particuology,2016,123(85):798-996
[17]Ma X,Ning G,Qi C,et al.One-step synthesis of basic magnesium sulfate whiskers by atmospheric pressure reflux[J].Particuology,2016,24(1):191-196
[18]Hsu PI,Lu CL,Wu DC,et al.Eight weeks of esomeprazole therapy reduces symptom relapse,compared with 4 weeks,in patients with los angeles grade a or B erosive esophagitis[J].Clin Gastroenterol Hepatol,2015,13(5):859-866
[19]Han WW,Zhang WP,Sun N.Technique of Tubularized Bladder Mucosa Method for Treating Recurrent Vesicoureteral Reflux[J].Chin Med J(Engl),2015,128(15):2109-2111
[20]Gong Y,Li Y,Sun Q.Probiotics improve efficacy and tolerability of triple therapy to eradicate Helicobacter pylori:a meta-analysis of randomized controlled trials[J].Int J Clin Exp Med,2015,8(4):6530-6543
[2]Yan Xue,Li-Ya Zhou,San-Ren Lin,et al.Effect of Helicobacterpylori Eradicationon Reflux Esophagitis Therapy:AMulti-center Randomized Control Study[J].Chin Med J(Engl),2015,128(8):995-999
[3]Kawami N,Lwakiri K,Sano H,et al.Effects of aging and acid reflux on esophageal motility[J].Digestion,2015,91(3):181-186
[4]Lee H S,Kang D I,Yoon S Z,et al.Evidence for novel age-dependent network structures as a putative primo vascular network in the dura mater of the rat brain[J].Neural Regeneration Research,2015,10(7):1101-1106
[5]Hanada K,Adachi K,Mishiro T,et al.Relationship between esophageal cardiac glands and gastroesophageal reflux disease[J].Intern Med,2015,54(2):91-96
[6]Nian Y Y,Feng C,Jing F C,et al.Reflux characteristics of 113 GERD patients with abnormal 24-h multichannel intraluminal impedance-p H tests[J].Journal of Zhejiang University(science.b),2015,16(9):805-810
[7]Wang RH.From reflux esophagitis to Barrett's esophagus and esophageal adenocarcinoma[J].World J Gastroenterol,2015,21(17):5210-5219
[8]АСТрухманов,ИВ Маев.Условный рефлекс и квантово-подобное поведение[J].Acta Mechanica Sinica,2014,85(24):24-55
[9]Nho K J,Chun J M,Kim D S,et al.D08.811.277.656.300.480.205.360[Categoria De CS][J].Chinese Journal of Polymer Science,2014,936(7):176-180
[10]Yue Q,Ye J Y,Han D M,et al.Esophageal Functional Changes in Obstructive Sleep Apnea/Hypopnea Syndrome and Their Impact on Laryngopharyngeal Reflux Disease[J].Chin Med J(Engl),2015,128(16):2162-2167
[11]Honda M,Hiki N,Nunobe S,et al.Preoperative vs Postoperative Eradication of Helicobacter pylori in 150 Patients with Gastric Cancer:A Randomized Controlled Trial[J].J Am Coll Surg,2015,221(2):273-279
[12]Yang C X,Huang X P,Lin J S,et al.Manufacture and Quality Control of Follicle Stimulating Hormone Products[J].Journal of Chinese Pharmaceutical Sciences,2014,49(7):529-533
[13]Teng M,Khoo AL,Zhao YJ,et al.Meta-analysis of the effectiveness of esomeprazole in gastroesophageal reflux disease and Helicobacter pylori infection[J].J Clin Pharm Ther,2015,20(4):209-221
[14]Orbelo DM,Enders FT,Romero Y,et al.Once-daily omeprazole/sodium bicarbonate heals severe refractory reflux esophagitis with morning or nighttime dosing[J].Dig Dis Sci,2015,60(1):146-162
[15]Sandip,Sabale,Vishwajeet.Synthesis and Properties of Monodisperse Superparamagnetic Mg_(0.8)Mn_(0.2)Fe_2O_4 Nanoparticles Using Polyol Reflux Method[J].Acta Metallurgica Sinica,2014,27(6):1122-1126
[16]Feng Y,Pan J,Liu H,et al.An acetic acid refluxing-electrochemistry combined strategy to activate supported-platinum electrocatalysts[J].Particuology,2016,123(85):798-996
[17]Ma X,Ning G,Qi C,et al.One-step synthesis of basic magnesium sulfate whiskers by atmospheric pressure reflux[J].Particuology,2016,24(1):191-196
[18]Hsu PI,Lu CL,Wu DC,et al.Eight weeks of esomeprazole therapy reduces symptom relapse,compared with 4 weeks,in patients with los angeles grade a or B erosive esophagitis[J].Clin Gastroenterol Hepatol,2015,13(5):859-866
[19]Han WW,Zhang WP,Sun N.Technique of Tubularized Bladder Mucosa Method for Treating Recurrent Vesicoureteral Reflux[J].Chin Med J(Engl),2015,128(15):2109-2111
[20]Gong Y,Li Y,Sun Q.Probiotics improve efficacy and tolerability of triple therapy to eradicate Helicobacter pylori:a meta-analysis of randomized controlled trials[J].Int J Clin Exp Med,2015,8(4):6530-6543