奥瑞凝胶对反流性食管炎患者血清胃泌素水平的影响
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摘要
目的:观察奥瑞凝胶对反流性食管炎患者血清胃泌素水平的影响。方法:60例反流性食管炎患者按照随机数表法将患者平均分为对照组和观察组。对照组患者给予常规治疗方法,观察组患者在对照组治疗基础上给予奥瑞凝胶。比较两组患者中医证候积分、临床疗效、胃镜疗效及胃泌素水平。结果:观察组胃镜疗效的痊愈率为43. 33%、显效率为40. 00%,均显著高于对照组的13. 33%、26. 67%;观察组胃镜疗效有效率为96. 67%,显著高于对照组的73. 33%,差异均有统计学意义(P <0. 05)。治疗后观察组患者中医证候积分:胸胁胀满(1. 35±0. 62)分、吞酸烧心(1. 05±0. 36)分、呃逆嗳气(1. 13±0. 64)分、情志抑郁(1. 25±0. 38)分等均显著低于对照组患者胸胁胀满[(3. 87±0. 63)分]、吞酸烧心[(3. 67±1. 13)分]、呃逆嗳气[(3. 18±0. 72)分]、情志抑郁[(2. 94±0. 55)分]的中医证候积分,差异均有统计学意义(P <0. 05)。观察组综合临床疗效的显效率为(50. 00%)显著高于对照组(30. 00%),无效率(6. 67%)显著低于对照组(33. 33%);观察组临床疗效有效率为(93. 33%)显著高于对照组(66. 67%),差异有统计学意义(P <0. 05)。两组患者治疗前血清胃泌素水平比较,差异无统计学意义(P> 0. 05);治疗后观察组患者血清胃泌素水平为(181. 03±21. 44)ng·L-1显著高于对照组患者的(114. 37±19. 85) ng·L-1,差异有统计学意义(P <0. 05)。结论:奥瑞凝胶治疗反流性食管炎患者临床疗效显著,可显著降低患者中医证候积分,提高胃泌素水平。
Objective: To observe the effects of orient gel on serum gastrin level in patients with reflux esophagitis. Methods: 60 patients with reflux esophagitis were randomly divided into control group and observation group according to random number table method. The patients in the control group were given conventional treatment,and the patients in the observation group were given Ori gel on the basis of the treatment of the control group. TCM syndrome scores,clinical efficacy,gastroscopic efficacy and gastrin levels were compared between the two groups. Results: The cure rate of the gastroscope in the observation group was 43. 33%,and the effective rate was 40. 00%,which was significantly higher than 13. 33% and 26. 67% of the control group. The effective rate of gastroscopy in the observation group was 96. 67%,which was significantly higher than that in the control group(73. 33%). The difference was statistically significant(P < 0. 05). After treatment,the TCM syndrome scores: thoracic fullness(1. 35 ± 0. 62),swallowing acid heartburn(1. 05 ± 0. 36),sputum sputum(1. 13 ± 0. 64),emotional depression(1. 25 ± 0. 38) of the observation group were significantly lower than the TCM syndrome scores(3. 87 ± 0. 63),swallowing heartburn(3. 67 ± 1. 13),hiccups(3. 18 ± 0. 72),and emotional depression(2. 94 ± 0. 55) of the control group. The effective rate of comprehensive clinical efficacy of the observation group was(50. 00%) significantly higher than that of the control group(30. 00%),and the inefficiency(6. 67%) was significantly lower than that of the control group(33. 33%). The effective rate of clinical observation in the observation group(93. 33%) was significantly higher than that in the control group(66. 67%),and the difference was statistically significant(P < 0. 05). There was no significant difference in serum gastrin levels between the two groups before treatment(P >0. 05). After treatment,the serum gastrin level of the observation group was(181. 03 ± 21. 44) ng·L-1 significantly higher than that of the control group(114. 37 ± 19. 85) ng·L-1,the difference was statistically significant(P < 0. 05). Conclusion: Ori Gel has a significant clinical effect in the treatment of patients with reflux esophagitis,which can significantly reduce TCM syndrome scores and increase gastrin levels.
Objective: To observe the effects of orient gel on serum gastrin level in patients with reflux esophagitis. Methods: 60 patients with reflux esophagitis were randomly divided into control group and observation group according to random number table method. The patients in the control group were given conventional treatment,and the patients in the observation group were given Ori gel on the basis of the treatment of the control group. TCM syndrome scores,clinical efficacy,gastroscopic efficacy and gastrin levels were compared between the two groups. Results: The cure rate of the gastroscope in the observation group was 43. 33%,and the effective rate was 40. 00%,which was significantly higher than 13. 33% and 26. 67% of the control group. The effective rate of gastroscopy in the observation group was 96. 67%,which was significantly higher than that in the control group(73. 33%). The difference was statistically significant(P < 0. 05). After treatment,the TCM syndrome scores: thoracic fullness(1. 35 ± 0. 62),swallowing acid heartburn(1. 05 ± 0. 36),sputum sputum(1. 13 ± 0. 64),emotional depression(1. 25 ± 0. 38) of the observation group were significantly lower than the TCM syndrome scores(3. 87 ± 0. 63),swallowing heartburn(3. 67 ± 1. 13),hiccups(3. 18 ± 0. 72),and emotional depression(2. 94 ± 0. 55) of the control group. The effective rate of comprehensive clinical efficacy of the observation group was(50. 00%) significantly higher than that of the control group(30. 00%),and the inefficiency(6. 67%) was significantly lower than that of the control group(33. 33%). The effective rate of clinical observation in the observation group(93. 33%) was significantly higher than that in the control group(66. 67%),and the difference was statistically significant(P < 0. 05). There was no significant difference in serum gastrin levels between the two groups before treatment(P >0. 05). After treatment,the serum gastrin level of the observation group was(181. 03 ± 21. 44) ng·L-1 significantly higher than that of the control group(114. 37 ± 19. 85) ng·L-1,the difference was statistically significant(P < 0. 05). Conclusion: Ori Gel has a significant clinical effect in the treatment of patients with reflux esophagitis,which can significantly reduce TCM syndrome scores and increase gastrin levels.
引文
[1]杜昕,袁红霞,檀金川,等.旋覆代赭汤加减治疗反流性食管炎临床研究[J].时珍国医国药,2013,24(1):162-164.
[2]王小晓,段飞,刘娟,等.奥瑞凝胶对反流性食管炎模型大鼠血清胃泌素及血浆胃动素分泌的影响[J].中国实验方剂学杂志,2010,16(12):142-143.
[3]杨少军,王晓敏,刘建鸿,等.胃安胶囊对功能性消化不良大鼠胃排空及胃动素、胃泌素的影响[J].时珍国医国药,2012,23(9):2156-2157.
[4]赵新功,王宇晖.雷贝拉唑联合康复新液治疗反流性食管炎的临床研究[J].西南国防医药,2017,27(5):476-478.
[5]张西嫔,孙媛,李瑞,等.胃力康颗粒联合疏肝调胃汤治疗反流性食管炎疗效及对胃肠动力的影响[J].现代中西医结合杂志,2017,26(36):4034-4036.
[6]王瑶,王敏.奥瑞凝胶对反流性食管炎大鼠模型食管组织中相关基因表达及血清相关分子含量的影响[J].海南医学院学报,2015,21(7):874-877.
[7]张国忠,周雪英.雷贝拉唑联合气滞胃痛颗粒治疗反流性食管炎的疗效及对患者血清胃泌素、血浆胃动素水平的影响[J].中国药师,2015,24(5):797-798,801.
[8]蒋振华,李修岭,杨帆,等.空腹血清胃蛋白酶原和胃泌素-17对反流性食管炎的诊断价值[J].中华实用诊断与治疗杂志,2017,31(1):39-41.
[9]赵艳,冯玉彦.化浊解毒方对浊毒内蕴型反流性食管炎大鼠黏膜脑肠肽及胃肠激素的影响[J].中成药,2014,36(8):1739-1741.
[10]PHAM,T H,GENTA,R M,SPECHLER,S J,et al. Development and Characterization of a Surgical Mouse Model of Reflux Esophagitis and Barrett's Esophagus[J]. J Gastrointest Surg,2014,18(2):234-241.
[11]PARK C H,KIM K O,BAEK I H,et al. Differences in the risk factors of reflux esophagitis according to age in Korea[J]. Dis Esophagus,2014,27(2):116-121.
[12]杨海卿,王科峰,郭伟,等.加味补中益气汤联合奥美拉唑肠溶胶囊治疗老年反流性食管炎的疗效及对生活质量和复发情况的影响[J].中国老年学杂志,2017,37(22):5642-5644.
[13]张红文,王准.镁加铝辅助治疗反流性食管炎患者的疗效及对其生存质量的影响[J].广西医科大学学报,2016,33(4):641-644.
[14]赵世民,杨彩丰,高春燕,等.雷贝拉唑联合四逆散治疗反流性食管炎的疗效及对血清胃泌素、血浆胃动素水平的影响[J].现代中西医结合杂志,2016,25(19):2093-2095.
[15]黄勇.降逆汤治疗反流性食管炎65例[J].河南中医,2014,34(12):2372-2373.
[16]DAVID A,KATZK A. The Complex Relationship between Eosinophiiic Esophagitis and Gastroesophageal Reflux Disease[J]. Digest Dis,2014,32(1/2):93-97.
[17]辛莘.雷贝拉唑与莫沙必利联合应用治疗反流性食管炎的临床效果观察[J].中国医刊,2017,52(10):96-98.
[18]谢妲.莫沙必利联合雷贝拉唑钠肠溶片治疗老年性反流性食管炎疗效评价[J].蚌埠医学院学报,2017,42(6):743-746,749.
[19]赵伟.空腹血清胃蛋白酶原和胃泌素-17对反流性食管炎的诊断价值[J].养生保健指南,2017,28(13):236.
[20]王学习,路莉,李少海,等.疏肝和胃颗粒对反流性食管炎大鼠平滑肌细胞收缩和血浆胃泌素、胃动素等的影响[J].中成药,2013,35(2):394-398.
[2]王小晓,段飞,刘娟,等.奥瑞凝胶对反流性食管炎模型大鼠血清胃泌素及血浆胃动素分泌的影响[J].中国实验方剂学杂志,2010,16(12):142-143.
[3]杨少军,王晓敏,刘建鸿,等.胃安胶囊对功能性消化不良大鼠胃排空及胃动素、胃泌素的影响[J].时珍国医国药,2012,23(9):2156-2157.
[4]赵新功,王宇晖.雷贝拉唑联合康复新液治疗反流性食管炎的临床研究[J].西南国防医药,2017,27(5):476-478.
[5]张西嫔,孙媛,李瑞,等.胃力康颗粒联合疏肝调胃汤治疗反流性食管炎疗效及对胃肠动力的影响[J].现代中西医结合杂志,2017,26(36):4034-4036.
[6]王瑶,王敏.奥瑞凝胶对反流性食管炎大鼠模型食管组织中相关基因表达及血清相关分子含量的影响[J].海南医学院学报,2015,21(7):874-877.
[7]张国忠,周雪英.雷贝拉唑联合气滞胃痛颗粒治疗反流性食管炎的疗效及对患者血清胃泌素、血浆胃动素水平的影响[J].中国药师,2015,24(5):797-798,801.
[8]蒋振华,李修岭,杨帆,等.空腹血清胃蛋白酶原和胃泌素-17对反流性食管炎的诊断价值[J].中华实用诊断与治疗杂志,2017,31(1):39-41.
[9]赵艳,冯玉彦.化浊解毒方对浊毒内蕴型反流性食管炎大鼠黏膜脑肠肽及胃肠激素的影响[J].中成药,2014,36(8):1739-1741.
[10]PHAM,T H,GENTA,R M,SPECHLER,S J,et al. Development and Characterization of a Surgical Mouse Model of Reflux Esophagitis and Barrett's Esophagus[J]. J Gastrointest Surg,2014,18(2):234-241.
[11]PARK C H,KIM K O,BAEK I H,et al. Differences in the risk factors of reflux esophagitis according to age in Korea[J]. Dis Esophagus,2014,27(2):116-121.
[12]杨海卿,王科峰,郭伟,等.加味补中益气汤联合奥美拉唑肠溶胶囊治疗老年反流性食管炎的疗效及对生活质量和复发情况的影响[J].中国老年学杂志,2017,37(22):5642-5644.
[13]张红文,王准.镁加铝辅助治疗反流性食管炎患者的疗效及对其生存质量的影响[J].广西医科大学学报,2016,33(4):641-644.
[14]赵世民,杨彩丰,高春燕,等.雷贝拉唑联合四逆散治疗反流性食管炎的疗效及对血清胃泌素、血浆胃动素水平的影响[J].现代中西医结合杂志,2016,25(19):2093-2095.
[15]黄勇.降逆汤治疗反流性食管炎65例[J].河南中医,2014,34(12):2372-2373.
[16]DAVID A,KATZK A. The Complex Relationship between Eosinophiiic Esophagitis and Gastroesophageal Reflux Disease[J]. Digest Dis,2014,32(1/2):93-97.
[17]辛莘.雷贝拉唑与莫沙必利联合应用治疗反流性食管炎的临床效果观察[J].中国医刊,2017,52(10):96-98.
[18]谢妲.莫沙必利联合雷贝拉唑钠肠溶片治疗老年性反流性食管炎疗效评价[J].蚌埠医学院学报,2017,42(6):743-746,749.
[19]赵伟.空腹血清胃蛋白酶原和胃泌素-17对反流性食管炎的诊断价值[J].养生保健指南,2017,28(13):236.
[20]王学习,路莉,李少海,等.疏肝和胃颗粒对反流性食管炎大鼠平滑肌细胞收缩和血浆胃泌素、胃动素等的影响[J].中成药,2013,35(2):394-398.