胃肠舒片治疗骨科术后便秘的临床研究
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摘要
目的:探讨胃肠舒片治疗骨科术后便秘的疗效。方法:共观察骨科术后便秘患者120例,随机分为两组,治疗组口服胃肠舒片,对照组口服复方芦荟胶囊,对比观察两组临床疗效、治疗前后便秘症状总积分和单项症状积分变化及药物毒副作用。结果:治疗组临床治愈率为60%,对照组为40%,治疗组治愈率显著高于对照组(P<0.05),治疗后治疗组便秘主要症状总积分为2.22±0.97,明显低于对照组总积分3.18±1.08。治疗后治疗组便秘症状单项积分分别为:大便性状0.52±0.11,排便难度0.50±0.13,排便间隔时间0.48±0.09,每次排便时间0.47±0.04,排便不尽或肛门阻塞感0.25±0.06,对照组便秘症状单项积分分别为:大便性状0.71±0.13,排便难度0.84±0.22,排便间隔时间0.81±0.15,每次排便时间0.79±0.08,排便不尽或肛门阻塞感0.38±0.03,治疗组便秘症状各单项积分均显著低于对照组(P<0.05),两组均未见明显毒副作用。结论:胃肠舒片治疗骨科术后便秘具有疗效好,无明显毒副作用的优势。
Objective:To investigate efficacy and side effects of Weichangshu tablets in the treatment of orthopedic postoperative constipation.Methods:120 patients with orthopedic postoperative constipation were randomly divided into two groups.The patients in the treatment group were treated with Weichangshu tablets,and the patients in the control group were treated with compound Luhui capsules.Then the clinical efficacy was observed and compared,including major changes of symptom scores and side effects of these medications.Results:The clinicalcure rate of the treatment group was 60%.It was significantly better than thatof the control group(40%)(P<0.05).Total score of the main symptoms of constipation of the treatment group(2.22± 0.97) was significantly lower than that of the controlgroup(3.18± 1.08)(P<0.05).The score of the individual symptom of the treatment group were significantly lower than that of the controlgroup(P<0.05).The score were respectively bowels character 0.52± 0.11vs0.71± 0.13,defecate difficulty 0.50± 0.13 vs 0.84±0.22,time interval of defecation 0.48± 0.09 vs 0.81± 0.15,time of each defecation 0.47± 0.04 vs 0.79± 0.08,feel of endless defecate or anus blocking 0.25± 0.06 vs 0.38± 0.03.The two groups showed no obvious side effects.Conclusions:Weichangshu has significant curative effect in treatment of orthopedic postoperative constipation,without significantside effects.
Objective:To investigate efficacy and side effects of Weichangshu tablets in the treatment of orthopedic postoperative constipation.Methods:120 patients with orthopedic postoperative constipation were randomly divided into two groups.The patients in the treatment group were treated with Weichangshu tablets,and the patients in the control group were treated with compound Luhui capsules.Then the clinical efficacy was observed and compared,including major changes of symptom scores and side effects of these medications.Results:The clinicalcure rate of the treatment group was 60%.It was significantly better than thatof the control group(40%)(P<0.05).Total score of the main symptoms of constipation of the treatment group(2.22± 0.97) was significantly lower than that of the controlgroup(3.18± 1.08)(P<0.05).The score of the individual symptom of the treatment group were significantly lower than that of the controlgroup(P<0.05).The score were respectively bowels character 0.52± 0.11vs0.71± 0.13,defecate difficulty 0.50± 0.13 vs 0.84±0.22,time interval of defecation 0.48± 0.09 vs 0.81± 0.15,time of each defecation 0.47± 0.04 vs 0.79± 0.08,feel of endless defecate or anus blocking 0.25± 0.06 vs 0.38± 0.03.The two groups showed no obvious side effects.Conclusions:Weichangshu has significant curative effect in treatment of orthopedic postoperative constipation,without significantside effects.
引文
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[6]郭金秀,王醊恩,刘孟安.中药胃肠舒对阿托品致胃肠动力障碍小鼠胃肠运动的影响[J].时珍国医国药,2010,21(2):264-265Guo Jin-xiu,Wang Zhui-en,Liu M eng-an.Effects of traditional Chinese Medicine Weichangshu on gastrointestinal movement of atropine-induced gastrointestinal motility disorder in mice[J].Lishizhen Medicine and Materia Medica Research,2010,21(2):264-265
[7]柯美云,罗金燕,许国铭.慢性便秘的诊治指南[J].中华内科杂志,2004,43(1):73-74Ke Mei-yun,Luo Jin-yan,Xu Guo-ming.The guide of the diagnosis and treatment of chronic constipation[J].Chinese Journal of Inte M edicine,2004,43(1):73-74
[8]国家中医管理局.中医病症诊断疗效标准[M].南京:南京大学出版社,1994:11The state administration of traditional Chinese medicine.The diagnosis curative standard of the symptoms of traditional Chinese m edicine[M].Nanjing:Press of nanjing university,1994:11
[9]张建军,李伟,王丽丽,等.赤芍和白芍品种、功效及临床应用述评[J].中国中药杂志,2013,38(20):3595-3601Zhang Jian-jun,Li Wei,Wang Li-li,et al.Varieties,functions and clinical applications of Chishao and Baishao:a literature review[J].China Journal of Chinese Materia Medica,2013,38(20):3595-3601
[10]吴其夏.新编病理生理学[M].北京:中国协和医科大学出版社,1998,321-351W u Qi-xia.Newly organized pathophysiology[M].Beijing:China union medical university press,1998,321-351
[11]苏攀.中医药治疗便秘型肠易激综合征疗效评价[J].河南中医,2014,34(7):1325-1327Su Pan.The evaluation of the effect of traditional Chinese medicine on treating constipation type of irritable bow el syndrom e[J].H enan Traditional Chinese Medicine,2014,34(7):1325-1327
[12]李琼,刘同慎,刘孟安.胃肠舒对胃肠功能障碍大鼠AchE及NO的影响[J].中华中医药杂志,2010,25(8):1307-1310Li Q iong,Liu Tong-shen,Liu M eng-an.Study on the effect oi Weichangshu Tablet on AchE and NO in rats with gastrointestinal dynam ics[J].China Journal of Traditional Chinese Medicine and Pharm acy,2010,25(8):1307-1310
[13]郭金秀,刘孟安,王连文,等.中药胃肠舒片对胃肠动力障碍大鼠血浆胃动素、P物质和生长抑素的影响[J].滨州医学院学报,201 34(1):1-3Guo Jimciu,Liu Meng-an,Wang Lian-wen,et al.The effect oi Weichangshu on plasm a M TL,SP and SS in rats of gastrointestinal motility disord[J].Journal of Binzhou Medical University,2011,34(1):1-3
[14]李琼,刘同慎,刘孟安.胃肠舒片对胃肠功能障碍大鼠胃肠道乙酰胆碱及P物质的影响[J].中国中医急症,2010,19(1):96-98Li Qiong,Liu Tong-shen,Liu Meng-an.Influence of Weichangshu Tab let on A ch and Substance P in G astro intestinal Tract of Rats with Gastrointestinal Dysfunction[J].Journal of Emergency in Traditional Chinese Medicine,2010,19(1):96-98
[15]宋晓冬,刘文波,张瑾锦,等.中药胃肠舒对糖尿病大鼠胃窦干细胞生长因子受体SCF-Kit与神经递质的影响[J].中华中医药杂志,2010,25(9):1404-1407Song Xiao-dong,Liu Wen-bo,Zhang Jin-jin,et al.Effect of Weichangshu on SCF-kit and neurotransmitters in sinus ventriculi of diabetic mellitus rats[J].China Journal of Traditional Chinese M edicine and Pharmacy,2010,25(9):1404-1407
[16]宋晓冬,王美蓉,张瑾锦,等.中药胃肠舒对Ca2+信号传导途径的调控[J].中国中医基础医学杂志,2011,11(8):866-869Song Xiao-dong,Wang Mei-rong,Zhang Jin-Jn,et al.Regulatory effectof WeiChang Shu on Ca2+signaling transduction pathway[J].Chinese Journal of Basic Medicine in Traditional Chinese Medicine,2011,11(8):866-869
[17]郭金秀,刘孟安.胃肠舒对胃肠平滑肌细胞一氧化氮释放的影响[J].中国实验方剂学杂志,2011,17(2):121-124Guo Jimciu,Liu Meng-an.Effectof Weichangshu on release of nitric oxide in gastrointestinal smooth muscle cells[J].Chinese Journal oi Experimental Traditional Medical Formulae,2011,17(2):121-124
[18]郭金秀,刘孟安.胃肠舒对胃肠平滑肌细胞内皮型一氧化氮合酶m RNA表达的影响[J].中华中医药杂志,2011,26(9):2087-2090Guo Jimciu,Liu Meng-an.Effect of Weichangshu on release oi nitrogen monoxidum and mRNA expression of endothelial nit coxide synthase in gastrointestinal smooth muscle cells[J].China Joumal of Traditional Chinese Medicine and Pharmacy,2011,26(9):2087-2090
[19]Shuai Zhou,Luping Zhang,Dongmei Zhao,et al.The effects oi Weichagshu tableton intracellular Ca2+concentration in cultured ra gastrointestinal smooth muscle cells[J].J physiol Biochem,2011,67:265-273
[20]李琼,郭金秀,刘孟安.胃肠舒对盐酸左旋精氨酸致大鼠胃肠动力障碍的影响[J].中国实验方剂学杂志,2010,16(8):106-108Li Qiong,Guo Jin-xiu,Liu Meng-an.Effect of Weichangshu Table on disfunction of gastrointestinal[J].Chinese Journal of Experimental Traditional Medical Formulae,2010,16(8):106-108
[2]陈贤慧,朱小舟,兰丽琴,等.断指再植患者绝对卧床期便秘的预防和护理[J].现代医药卫生,2013,29(10):515-516Chen Xian-hui,Zhu Xiao-zhou,Lan Li-qin,et al.The prevention and care of the patients operating replantation in bed with constipation[J].Modern Medicine&Health,2013,29(10):515-516
[3]Thurmann PA.A dverse drugs reactions:diagnosis and assessment Patholog,2006,27(1):6-12
[4]Makimoto N,Sakurai-Yam ashita Y,Furuichi A,et al.In vivo assessment of acceleration of motor activity associated with acetylcholine release via 5-hydroxytryplamine4 receptor in dog intestine[J].Jpn JPharm acof,2002,90(1):28-35
[5]郭金秀,刘孟安,王慧凯.中药胃肠舒片对胃肠动力障碍小鼠胃排空及肠推进影响的实验研究[J].辽宁中医杂志,2010,37 751-752Guo Jin-xiu,Liu M eng-an,Wang Hurkai.Experimeial study of Chinese medicine tablets Weichangshus'influence on gastric emptying and intestinal propulsion of gastrointestinal motility disorder in mice[J].Liaoning Journal of Traditional Chinese M edicine,2010,37(4):751-752
[6]郭金秀,王醊恩,刘孟安.中药胃肠舒对阿托品致胃肠动力障碍小鼠胃肠运动的影响[J].时珍国医国药,2010,21(2):264-265Guo Jin-xiu,Wang Zhui-en,Liu M eng-an.Effects of traditional Chinese Medicine Weichangshu on gastrointestinal movement of atropine-induced gastrointestinal motility disorder in mice[J].Lishizhen Medicine and Materia Medica Research,2010,21(2):264-265
[7]柯美云,罗金燕,许国铭.慢性便秘的诊治指南[J].中华内科杂志,2004,43(1):73-74Ke Mei-yun,Luo Jin-yan,Xu Guo-ming.The guide of the diagnosis and treatment of chronic constipation[J].Chinese Journal of Inte M edicine,2004,43(1):73-74
[8]国家中医管理局.中医病症诊断疗效标准[M].南京:南京大学出版社,1994:11The state administration of traditional Chinese medicine.The diagnosis curative standard of the symptoms of traditional Chinese m edicine[M].Nanjing:Press of nanjing university,1994:11
[9]张建军,李伟,王丽丽,等.赤芍和白芍品种、功效及临床应用述评[J].中国中药杂志,2013,38(20):3595-3601Zhang Jian-jun,Li Wei,Wang Li-li,et al.Varieties,functions and clinical applications of Chishao and Baishao:a literature review[J].China Journal of Chinese Materia Medica,2013,38(20):3595-3601
[10]吴其夏.新编病理生理学[M].北京:中国协和医科大学出版社,1998,321-351W u Qi-xia.Newly organized pathophysiology[M].Beijing:China union medical university press,1998,321-351
[11]苏攀.中医药治疗便秘型肠易激综合征疗效评价[J].河南中医,2014,34(7):1325-1327Su Pan.The evaluation of the effect of traditional Chinese medicine on treating constipation type of irritable bow el syndrom e[J].H enan Traditional Chinese Medicine,2014,34(7):1325-1327
[12]李琼,刘同慎,刘孟安.胃肠舒对胃肠功能障碍大鼠AchE及NO的影响[J].中华中医药杂志,2010,25(8):1307-1310Li Q iong,Liu Tong-shen,Liu M eng-an.Study on the effect oi Weichangshu Tablet on AchE and NO in rats with gastrointestinal dynam ics[J].China Journal of Traditional Chinese Medicine and Pharm acy,2010,25(8):1307-1310
[13]郭金秀,刘孟安,王连文,等.中药胃肠舒片对胃肠动力障碍大鼠血浆胃动素、P物质和生长抑素的影响[J].滨州医学院学报,201 34(1):1-3Guo Jimciu,Liu Meng-an,Wang Lian-wen,et al.The effect oi Weichangshu on plasm a M TL,SP and SS in rats of gastrointestinal motility disord[J].Journal of Binzhou Medical University,2011,34(1):1-3
[14]李琼,刘同慎,刘孟安.胃肠舒片对胃肠功能障碍大鼠胃肠道乙酰胆碱及P物质的影响[J].中国中医急症,2010,19(1):96-98Li Qiong,Liu Tong-shen,Liu Meng-an.Influence of Weichangshu Tab let on A ch and Substance P in G astro intestinal Tract of Rats with Gastrointestinal Dysfunction[J].Journal of Emergency in Traditional Chinese Medicine,2010,19(1):96-98
[15]宋晓冬,刘文波,张瑾锦,等.中药胃肠舒对糖尿病大鼠胃窦干细胞生长因子受体SCF-Kit与神经递质的影响[J].中华中医药杂志,2010,25(9):1404-1407Song Xiao-dong,Liu Wen-bo,Zhang Jin-jin,et al.Effect of Weichangshu on SCF-kit and neurotransmitters in sinus ventriculi of diabetic mellitus rats[J].China Journal of Traditional Chinese M edicine and Pharmacy,2010,25(9):1404-1407
[16]宋晓冬,王美蓉,张瑾锦,等.中药胃肠舒对Ca2+信号传导途径的调控[J].中国中医基础医学杂志,2011,11(8):866-869Song Xiao-dong,Wang Mei-rong,Zhang Jin-Jn,et al.Regulatory effectof WeiChang Shu on Ca2+signaling transduction pathway[J].Chinese Journal of Basic Medicine in Traditional Chinese Medicine,2011,11(8):866-869
[17]郭金秀,刘孟安.胃肠舒对胃肠平滑肌细胞一氧化氮释放的影响[J].中国实验方剂学杂志,2011,17(2):121-124Guo Jimciu,Liu Meng-an.Effectof Weichangshu on release of nitric oxide in gastrointestinal smooth muscle cells[J].Chinese Journal oi Experimental Traditional Medical Formulae,2011,17(2):121-124
[18]郭金秀,刘孟安.胃肠舒对胃肠平滑肌细胞内皮型一氧化氮合酶m RNA表达的影响[J].中华中医药杂志,2011,26(9):2087-2090Guo Jimciu,Liu Meng-an.Effect of Weichangshu on release oi nitrogen monoxidum and mRNA expression of endothelial nit coxide synthase in gastrointestinal smooth muscle cells[J].China Joumal of Traditional Chinese Medicine and Pharmacy,2011,26(9):2087-2090
[19]Shuai Zhou,Luping Zhang,Dongmei Zhao,et al.The effects oi Weichagshu tableton intracellular Ca2+concentration in cultured ra gastrointestinal smooth muscle cells[J].J physiol Biochem,2011,67:265-273
[20]李琼,郭金秀,刘孟安.胃肠舒对盐酸左旋精氨酸致大鼠胃肠动力障碍的影响[J].中国实验方剂学杂志,2010,16(8):106-108Li Qiong,Guo Jin-xiu,Liu Meng-an.Effect of Weichangshu Table on disfunction of gastrointestinal[J].Chinese Journal of Experimental Traditional Medical Formulae,2010,16(8):106-108