胃肠舒片促进胃肠运动的有效部位筛选研究
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摘要
目的筛选胃肠舒片促进胃肠运动的主要有效部位。方法根据胃肠舒片的配伍特点,通过观察胃肠舒片与正常组大鼠胃排空、小肠推进的影响,筛选胃肠舒片促进胃肠运动的有效部位和活性部位。结果胃肠舒片经提取得到A、B、a、b、c、d、e、f等8个有效部位,实验表明B、a、b、d、f组有促进正常大鼠小肠推进的作用,差异有统计学意义(P<0.05);各组对促进胃排空效果不明显,无统计学意义。结论胃肠舒片有调节胃肠运动的作用,其有效部位为B、a、b、d、f五部分。
Objective To screen the active fractions that were able to promote gastrointestinal motility in Weichangshu pills.Methods According to the characteristics of compatibility of Weichangshu pills,we first at all observed the effect of weichangshu pills on gastric emptying and small intestine propulsion in normal rats. Screening of the effective parts and active site of Weichangshu pills what promote gastrointestinal movement. Results Extracting from weichangshu pills,we can get effective parts of A,B,a,b,c,d,e,f. Its B,a,b,d、f groups could promote gastric emptying of normal rats. Its f groups could promote small intestine propulsion of normal rats. Conclusion Weichangshu pills could promote gastric emptying in normal rats. Part B,a,b,d,f are the main effective part of Weichangshu pills.
Objective To screen the active fractions that were able to promote gastrointestinal motility in Weichangshu pills.Methods According to the characteristics of compatibility of Weichangshu pills,we first at all observed the effect of weichangshu pills on gastric emptying and small intestine propulsion in normal rats. Screening of the effective parts and active site of Weichangshu pills what promote gastrointestinal movement. Results Extracting from weichangshu pills,we can get effective parts of A,B,a,b,c,d,e,f. Its B,a,b,d、f groups could promote gastric emptying of normal rats. Its f groups could promote small intestine propulsion of normal rats. Conclusion Weichangshu pills could promote gastric emptying in normal rats. Part B,a,b,d,f are the main effective part of Weichangshu pills.
引文
[1]刘竺华.健脾通腑汤治疗胃肠动力障碍性疾病60例疗效观察[J].山西中医学院学报,2008,9(4):21.
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[6]刘德胜,吕青志,栾海云,等.胃肠舒片中总蒽醌及5种游离蒽醌的含量测定[J].中药材,2011,34(9):1456.
[7]赵永德,丁昌成,贾善学.RP-HPLC法测定胃肠舒片中芍药苷的含量[J].中国药师2005,8(12):1007.
[8]刘德胜,龙姣燕,张树平,等.胃肠舒片的溶出度研究[J].中国药业,2013,22(8):53.
[9]刘德胜,吕青志,栾海云,等.胃肠舒片的质量标准[J].中国药师,2012,15(10):1396.
[2]郭金秀,刘孟安,王慧凯.中药胃肠舒片对胃肠动力障碍小鼠胃排空及肠推进影响的实验研究[J].辽宁中医杂志,2010,37(4):751.
[3]胡建英.胃肠动力障碍性疾病发病机制及其药物研究概况[J].海峡药学,2008,20(11):110.
[4]杨小军,李建军,轩原清史,等.白芍总甙对豚鼠结肠平滑肌作用机制的研究[J].中国中西医结合消化杂志,2002,10(3):151.
[5]蒋军,张勤.大黄素促胃肠动力机制研究概况[J].医学研究杂志,2011,40(5):20.
[6]刘德胜,吕青志,栾海云,等.胃肠舒片中总蒽醌及5种游离蒽醌的含量测定[J].中药材,2011,34(9):1456.
[7]赵永德,丁昌成,贾善学.RP-HPLC法测定胃肠舒片中芍药苷的含量[J].中国药师2005,8(12):1007.
[8]刘德胜,龙姣燕,张树平,等.胃肠舒片的溶出度研究[J].中国药业,2013,22(8):53.
[9]刘德胜,吕青志,栾海云,等.胃肠舒片的质量标准[J].中国药师,2012,15(10):1396.