多指标综合评分法优选金山开胃丸的成型工艺
|
摘要
目的:优选金山开胃丸的成型工艺。方法:以总黄酮测得量、质量差异、水分、溶散时限、成品率作为评价指标,采用AHP-CRITIC混合加权法确定各指标权重系数,对正交试验结果进行综合评分,优化成型工艺参数。结果:最佳工艺条件为药蜜比1∶0.40,药粉细度60目,干燥温度60℃,干燥时间12 h。结论:该成型工艺稳定合理,可用于金山开胃丸的制备。
Objective: To optimize the forming process for Jinshan Kaiwei Pills. Methods: With total flavonoids content, weighing deviation, moisture content, disintegration time and yield as evaluation indexes, the weighting coefficient in five evaluation indexes were determined by mixed weighted Analytic Hierarchy Process and Criteria importance through intercriteria correlation(AHP-CRITIC). Forming process was optimized by comprehensive score of orthogonal test results. Results: The optimized process conditions were obtained with: ratio of powder to honey 1∶0.40, particle size of powder 60 mesh, drying temperature 60 ℃, drying time 12 h. Conclusion: The forming process was stable and reasonable, which can be used for the production of Jinshan Kaiwei Pills.
Objective: To optimize the forming process for Jinshan Kaiwei Pills. Methods: With total flavonoids content, weighing deviation, moisture content, disintegration time and yield as evaluation indexes, the weighting coefficient in five evaluation indexes were determined by mixed weighted Analytic Hierarchy Process and Criteria importance through intercriteria correlation(AHP-CRITIC). Forming process was optimized by comprehensive score of orthogonal test results. Results: The optimized process conditions were obtained with: ratio of powder to honey 1∶0.40, particle size of powder 60 mesh, drying temperature 60 ℃, drying time 12 h. Conclusion: The forming process was stable and reasonable, which can be used for the production of Jinshan Kaiwei Pills.
引文
[1]国家中医药管理局《中华本草》编委会.中华本草(第四卷)[M].上海:上海科学技术出版社,1999:936-938.
[2]国家药典委员会.中国药典(一部)[M].北京:中国医药科技出版社,2015.
[3]唐巧玉,周毅峰,朱玉昌,等.金橘皮中黄酮类物质的提取及其体外抗氧化活性研究[J].农业工程学报,2008,24(6):258-261.
[4]詹文强,王炯,尚佳,等.杜仲腰痛浓缩丸制备工艺优化[J].中国实验方剂学杂志,2013,19(5):71-73.
[5]陈娇,余姣,江敏瑜,等.基于多指标权重分析和正交设计法对三七跌打损伤软膏提取工艺的探究[J].中药材,2017,40(2):412-415.
[6]霍务贞,李大炜,朱盛山.浅议《本草纲目特殊制药施药技术》中丸剂辅料的作用[J].中国药房,2010,21(39):3742-3744.
[7]葛永斌.金橘化学成分研究[J].中药材,2014,37(3):435-438.
[8]吴士杰,李秋津,肖学凤,等.山楂化学成分及药理作用的研究[J].药物评价研究,2010,33(4):316-319.
[9]李欣然,王静,余晓燕,等.陈皮的研究进展[J].中国医药指南,2016,14(24):31-32.
[10]丁晓琴,张德生.基于AHP和CRITIC综合赋权的K-means算法[J].计算机系统应用,2016,25(7):182-186.
[2]国家药典委员会.中国药典(一部)[M].北京:中国医药科技出版社,2015.
[3]唐巧玉,周毅峰,朱玉昌,等.金橘皮中黄酮类物质的提取及其体外抗氧化活性研究[J].农业工程学报,2008,24(6):258-261.
[4]詹文强,王炯,尚佳,等.杜仲腰痛浓缩丸制备工艺优化[J].中国实验方剂学杂志,2013,19(5):71-73.
[5]陈娇,余姣,江敏瑜,等.基于多指标权重分析和正交设计法对三七跌打损伤软膏提取工艺的探究[J].中药材,2017,40(2):412-415.
[6]霍务贞,李大炜,朱盛山.浅议《本草纲目特殊制药施药技术》中丸剂辅料的作用[J].中国药房,2010,21(39):3742-3744.
[7]葛永斌.金橘化学成分研究[J].中药材,2014,37(3):435-438.
[8]吴士杰,李秋津,肖学凤,等.山楂化学成分及药理作用的研究[J].药物评价研究,2010,33(4):316-319.
[9]李欣然,王静,余晓燕,等.陈皮的研究进展[J].中国医药指南,2016,14(24):31-32.
[10]丁晓琴,张德生.基于AHP和CRITIC综合赋权的K-means算法[J].计算机系统应用,2016,25(7):182-186.