蠕虫对肠道菌群的影响及在宿主免疫中的作用
|
摘要
胃肠道寄生虫与共生菌群等其它有机体共享肠道栖息地。研究表明在脊椎动物感染的模型中,蠕虫和肠道微生物菌群之间存在大量的相互作用,对宿主免疫和代谢产生重要影响。本文将蠕虫-微生物群相互作用以及在宿主免疫中的作用进行综述,旨在为蠕虫-肠道菌群相互作用的研究提供理论依据。
Gastrointestinal parasites share symbiotic habitats with other organisms such as commensal flora.Studies have shown that there are a large number of interactions between helminth and gut microflora in vertebrate infection models that have a major impact on host immunity and metabolism.This review summarizes the interactions between helminth and microorganisms and their roles in host immunity and aims to provide a theoretical basis for the study of the interaction between helminth and gut microbes.
Gastrointestinal parasites share symbiotic habitats with other organisms such as commensal flora.Studies have shown that there are a large number of interactions between helminth and gut microflora in vertebrate infection models that have a major impact on host immunity and metabolism.This review summarizes the interactions between helminth and microorganisms and their roles in host immunity and aims to provide a theoretical basis for the study of the interaction between helminth and gut microbes.
引文
[1]Iizumi T,Battaglia T,Ruiz V,et al.Gut microbiome and antibiotics[J].Arch Med Res,Available online 6December 2017.DOI:10.1016/j.arcmed.2017.11.004
[2]Guinane CM,Cotter PD.Role of the gut microbiota in health and chronic gastrointestinal disease:understanding a hidden metabolic organ[J].Ther Adv Gas troenter,2013,6(4):295-308.DOI:10.1177/1756283X13482996
[3]Mclean MH,Dieguez Jr D,Miller LM,et al.Does the microbiota play a role in the pathogenesis of autoimmune disease[J]Gut,2015,64(2):332-341.DOI:10.1136/gutjnl-2014-308514
[4]Geuking MB,Cahenzli J,Lawson MA,et al.Intestinal bacterial colonization induces mutualistic regulatory T cell responses[J].Immunity,2011,34(5):794-806.DOI:10.1016/j.immuni.2011.03.021
[5]Farkas AM,Panea C,Goto Y,et al.Induction of Th17cells by segmented filamentous bacteria in the murine intestine[J].J Immunol Methods,2015,421:104-111.DOI:10.1016/j.jim.2015.03.020
[6]Belkaid Y,Hand TW.Role of the microbiota in immunity and inflammation[J].Cell,2014,157(1):121-41.DOI:10.1016/j.cell.2014.03.011
[7]Round JL,Mazmanian SK.Inducible Foxp3+regulatory T-cell development by a commensal bacterium of the intestinal microbiota[J].Proc Natl Acad Sci USA,2010,107(27):12204-12209.DOI:10.1073/pnas.0909122107
[8]Sargison N.D,Wilson DJ,Penny CD,et al.Unexpected production loss caused by helminth parasites in weaned beef calves[J].Vet Rec,2010,167(19):752-754.DOI:10.1136/vr.c5428
[9]Nono JK,Ndlovu H,Abdel AN.Interleukin-4receptor alpha is still required after Th2polarization for the maintenance and the recall of protective immunity to Nematode infection[J].PLoS Neglect Trop,2017,11(6):e0005675.DOI:10.1371/journal.pntd.0005675
[10]Garg SK,Croft AM,Bager P.Helminth therapy(worms)for induction of remission in inflammatory bowel disease[M].John Wiley&Sons,Ltd,2014,1(1):CD009400-CD009400.DOI:10.1002/14651858
[11]Reynolds LA,Smith KA,Filbey KJ,et al.Commensal-pathogen interactions in the intestinal tract:lactobacilli promote infection with,and are promoted by,helminth parasites[J].Gut Microbes,2014,5(4):522-32.DOI:10.4161/gmic.32155.
[12]Medzhitov R,Schneider D,Soares M,et al.Disease tolerance as a defense strategy[J].Science,2012,335:936-941.DOI:10.1126/science.1214935
[13]Houlden A,Hayes KS,Bancroft AJ,et al.Chronic trichuris muris infection in C57BL/6 mice causes significant changes in host microbiota and metabolome:effects reversed by pathogen clearance[J].PLoS One,2015,10(5):e0125945.DOI:10.1371/journal.pone.0125945
[14]Geuking MB,Cahenzli J,Lawson MA,et al.Intestinal bacterial colonization induces mutualistic regulatory T cell responses[J].Immunity,2011,34(5):794-806.DOI:10.1016/j.immu-ni.2011.03.021
[15]Forbes EE,Groschwitz K,Abonia JP,et al.IL-9and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity[J].J Exp Med,2008,205(4):897-913.DOI:10.1084/jem.20071046
[16]Chang HC,Sehra S,Goswami R,et al.The transcription factor PU.1is required for the development of IL-9-producing T cells and allergic inflammation[J].Nat Immunol,2010,11(6):527-534.DOI:10.1038/ni.1867
[17]Wills-Karp M,Rani R,Dienger K,et al.Trefoil factor 2rapidly induces interleukin 33to promote type 2immunity during allergic asthma and hookworm infection[J].J Exp Med,2012,209(3):607-622.DOI:10.1084/jem.20110079
[18]Patel N,Wu W,Mishra PK,et al.A2Badenosine receptor induces protective antihelminth type 2immune responses[J].Cell Host Microbe,2014,15(3):339-350.DOI:10.1016/j.chom.2014.02.001
[19]Gerbe F,Sidot E,Smyth DJ,et al.Intestinal epithelial tuft cells initiate type 2mucosal immunity to helminth parasites[J].Nature,2016,529(7585):226.DOI:10.1038/nature16527
[20]Hasnain SZ,Evans CM,Roy M,et al.Muc5ac:a critical component mediating the rejection of enteric nematodes[J].J Exp Med,2011,208(5):893-900.DOI:10.1084/jem.20102057
[21]Guivier E,Lippens C,Faivre B,et al.Plastic and micro-evolutionary responses of a nematode to the host immune environment[J].Exp Parasitol,2017(181)14-22.DOI:10.1016/j.exppara.2017.07.002
[22]Verdelho MM,Helena CP.Diet,Microbiota,obesity,and NAFLD:A dangerous quartet[J].Int J Mol SCI,2016,17(4):481.DOI:10.3390/ijms17040481
[23]Ramstead AG,Robison A,Blackwell A,et al.Roles of TLR2,TLR4,and MyD88during pulmonary Coxiella burnetii infection[J].Infect Immun,2016,84(4):657-674.DOI:10.1128/IAI.00898-15
[24]Reynolds LA,Harcus Y,Smith KA,et al.MyD88signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus[J].J Immunol,2014,193(6):2984-2993.DOI:10.4049/jimmunol.1401056
[25]Geuking MB,Cahenzli J,Lawson MA,et al.Intestinal bacterial colonization induces mutualistic regulatory T cell responses[J].Immunity,2011,34(5):794-806.DOI:10.1016/j.immu ni.2011.03.021
[26]Partidarodríguez O,Serranovázquez A,Nievesramírez ME,et al.Human intestinal microbiota:interaction between parasites and the host immune response[J].Arch Med Res,2017 12(28):S0188-4409(17)30248-5.DOI:10.1016/j.arcmed.2017.11.015
[27]Ohnmacht C,Park JH,Cording S,et al.The microbiota regulates type 2immunity through RORγt+T cells[J].Science,2015,349(6251):989-993.DOI:10.1126/science.aac4263
[28]McSorley HJ,Maizels RM.Helminth infections and host immune regulation[J].Clin Microbiol Rev,2012,25(4):585-608.DOI:10.1128/CMR.05040-11
[29]Zakeri A,Borji H,Haghparast A.Interaction between helminths and toll-like receptors:possibilities and potentials for asthma therapy[J].Int Rev Immunol,2016,35(3):219-248.DOI:10.3109/08830185.2015.1096936
[30]Kim SV,Xiang WV,Kwak C,et al.GPR15-mediated homing controlos immune homeostasis in the large intestine mucosa[J].Nature,2013,504(7480):451-455.DOI:10.1126/science.1237013
[2]Guinane CM,Cotter PD.Role of the gut microbiota in health and chronic gastrointestinal disease:understanding a hidden metabolic organ[J].Ther Adv Gas troenter,2013,6(4):295-308.DOI:10.1177/1756283X13482996
[3]Mclean MH,Dieguez Jr D,Miller LM,et al.Does the microbiota play a role in the pathogenesis of autoimmune disease[J]Gut,2015,64(2):332-341.DOI:10.1136/gutjnl-2014-308514
[4]Geuking MB,Cahenzli J,Lawson MA,et al.Intestinal bacterial colonization induces mutualistic regulatory T cell responses[J].Immunity,2011,34(5):794-806.DOI:10.1016/j.immuni.2011.03.021
[5]Farkas AM,Panea C,Goto Y,et al.Induction of Th17cells by segmented filamentous bacteria in the murine intestine[J].J Immunol Methods,2015,421:104-111.DOI:10.1016/j.jim.2015.03.020
[6]Belkaid Y,Hand TW.Role of the microbiota in immunity and inflammation[J].Cell,2014,157(1):121-41.DOI:10.1016/j.cell.2014.03.011
[7]Round JL,Mazmanian SK.Inducible Foxp3+regulatory T-cell development by a commensal bacterium of the intestinal microbiota[J].Proc Natl Acad Sci USA,2010,107(27):12204-12209.DOI:10.1073/pnas.0909122107
[8]Sargison N.D,Wilson DJ,Penny CD,et al.Unexpected production loss caused by helminth parasites in weaned beef calves[J].Vet Rec,2010,167(19):752-754.DOI:10.1136/vr.c5428
[9]Nono JK,Ndlovu H,Abdel AN.Interleukin-4receptor alpha is still required after Th2polarization for the maintenance and the recall of protective immunity to Nematode infection[J].PLoS Neglect Trop,2017,11(6):e0005675.DOI:10.1371/journal.pntd.0005675
[10]Garg SK,Croft AM,Bager P.Helminth therapy(worms)for induction of remission in inflammatory bowel disease[M].John Wiley&Sons,Ltd,2014,1(1):CD009400-CD009400.DOI:10.1002/14651858
[11]Reynolds LA,Smith KA,Filbey KJ,et al.Commensal-pathogen interactions in the intestinal tract:lactobacilli promote infection with,and are promoted by,helminth parasites[J].Gut Microbes,2014,5(4):522-32.DOI:10.4161/gmic.32155.
[12]Medzhitov R,Schneider D,Soares M,et al.Disease tolerance as a defense strategy[J].Science,2012,335:936-941.DOI:10.1126/science.1214935
[13]Houlden A,Hayes KS,Bancroft AJ,et al.Chronic trichuris muris infection in C57BL/6 mice causes significant changes in host microbiota and metabolome:effects reversed by pathogen clearance[J].PLoS One,2015,10(5):e0125945.DOI:10.1371/journal.pone.0125945
[14]Geuking MB,Cahenzli J,Lawson MA,et al.Intestinal bacterial colonization induces mutualistic regulatory T cell responses[J].Immunity,2011,34(5):794-806.DOI:10.1016/j.immu-ni.2011.03.021
[15]Forbes EE,Groschwitz K,Abonia JP,et al.IL-9and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity[J].J Exp Med,2008,205(4):897-913.DOI:10.1084/jem.20071046
[16]Chang HC,Sehra S,Goswami R,et al.The transcription factor PU.1is required for the development of IL-9-producing T cells and allergic inflammation[J].Nat Immunol,2010,11(6):527-534.DOI:10.1038/ni.1867
[17]Wills-Karp M,Rani R,Dienger K,et al.Trefoil factor 2rapidly induces interleukin 33to promote type 2immunity during allergic asthma and hookworm infection[J].J Exp Med,2012,209(3):607-622.DOI:10.1084/jem.20110079
[18]Patel N,Wu W,Mishra PK,et al.A2Badenosine receptor induces protective antihelminth type 2immune responses[J].Cell Host Microbe,2014,15(3):339-350.DOI:10.1016/j.chom.2014.02.001
[19]Gerbe F,Sidot E,Smyth DJ,et al.Intestinal epithelial tuft cells initiate type 2mucosal immunity to helminth parasites[J].Nature,2016,529(7585):226.DOI:10.1038/nature16527
[20]Hasnain SZ,Evans CM,Roy M,et al.Muc5ac:a critical component mediating the rejection of enteric nematodes[J].J Exp Med,2011,208(5):893-900.DOI:10.1084/jem.20102057
[21]Guivier E,Lippens C,Faivre B,et al.Plastic and micro-evolutionary responses of a nematode to the host immune environment[J].Exp Parasitol,2017(181)14-22.DOI:10.1016/j.exppara.2017.07.002
[22]Verdelho MM,Helena CP.Diet,Microbiota,obesity,and NAFLD:A dangerous quartet[J].Int J Mol SCI,2016,17(4):481.DOI:10.3390/ijms17040481
[23]Ramstead AG,Robison A,Blackwell A,et al.Roles of TLR2,TLR4,and MyD88during pulmonary Coxiella burnetii infection[J].Infect Immun,2016,84(4):657-674.DOI:10.1128/IAI.00898-15
[24]Reynolds LA,Harcus Y,Smith KA,et al.MyD88signaling inhibits protective immunity to the gastrointestinal helminth parasite Heligmosomoides polygyrus[J].J Immunol,2014,193(6):2984-2993.DOI:10.4049/jimmunol.1401056
[25]Geuking MB,Cahenzli J,Lawson MA,et al.Intestinal bacterial colonization induces mutualistic regulatory T cell responses[J].Immunity,2011,34(5):794-806.DOI:10.1016/j.immu ni.2011.03.021
[26]Partidarodríguez O,Serranovázquez A,Nievesramírez ME,et al.Human intestinal microbiota:interaction between parasites and the host immune response[J].Arch Med Res,2017 12(28):S0188-4409(17)30248-5.DOI:10.1016/j.arcmed.2017.11.015
[27]Ohnmacht C,Park JH,Cording S,et al.The microbiota regulates type 2immunity through RORγt+T cells[J].Science,2015,349(6251):989-993.DOI:10.1126/science.aac4263
[28]McSorley HJ,Maizels RM.Helminth infections and host immune regulation[J].Clin Microbiol Rev,2012,25(4):585-608.DOI:10.1128/CMR.05040-11
[29]Zakeri A,Borji H,Haghparast A.Interaction between helminths and toll-like receptors:possibilities and potentials for asthma therapy[J].Int Rev Immunol,2016,35(3):219-248.DOI:10.3109/08830185.2015.1096936
[30]Kim SV,Xiang WV,Kwak C,et al.GPR15-mediated homing controlos immune homeostasis in the large intestine mucosa[J].Nature,2013,504(7480):451-455.DOI:10.1126/science.1237013