健康体检人群胃部疾病相关血清学标志物含量分析及异常结果干预策略
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摘要
目的通过检测并分析健康体检人群中胃部疾病相关血清学标志物的含量及其影响因素,为胃部疾病的诊断及风险评估提供参考,并探讨胃部疾病相关血清学标志物异常结果的干预策略。方法选取2015年5月至2016年4月来我院进行健康体检人员555例作为研究对象,测定受检者血清胃蛋白酶原I(PGI)、胃蛋白酶原II(PGII)、胃泌素-17(G-17)和Hp-IgG抗体等指标。结果在555例体检人群中,随着年龄增长,PGI、PGII、G-17含量上升而PGI/PGII下降。Hp阳性组血清PGI、PGII、G-17含量较Hp阴性组升高,而PGI/PGII下降。依据血清PGI、PGII、G-17、Hp-IgG抗体四种不同组合进行胃部疾病风险评估:A组354例(63.78%),B组192例(34.59%),C组9例(1.62%)。结论 PGI、PGII、G-17指标与年龄、Hp感染呈正相关,健康体检人群中,有较高的血清PG、G-17异常率和Hp感染率,我们依据胃部疾病风险评估情况,应对体检人群进行分层健康管理,并给予积极干预与管理。
Objective To detect and analyze the serological markers of gastric disease levels in healthy people check-up and its influencing factors,to provide reference for diagnosis and risk assessment for gastric disease,and to explore the management measures for people with abnormal gastric. Methods Detect the serum levels of PGI,PGII,G-17 and the anti-Hp-IgG for 555 subjects in routine medical check-up. Results The results show ed that the PGI,PGII and G-17 level increased with age whereas PGI/PGII show ed a downw ard trend with age. For the Hp-positive group,the serum levels of PGI、PGII and G-17 were significantly higher than those of the Hp-negative group,while the PGI/PGII was significantly lower. Risk assessment of gastric disease were based on serum levels of PGI,PGII,G-17 and the anti-Hp-IgG : Group A included 354 people(63. 78%),Group B included 192 people(34. 59%),Group C included 9 people(1. 62%). Conclusion The serum level of PG and G-17 increased with age,as well as Hp infection. There were higher serum level of PG,abnormal G-17 and Hp infection rate in general population. We should provide stratified health management,and give active intervention and treatment.
Objective To detect and analyze the serological markers of gastric disease levels in healthy people check-up and its influencing factors,to provide reference for diagnosis and risk assessment for gastric disease,and to explore the management measures for people with abnormal gastric. Methods Detect the serum levels of PGI,PGII,G-17 and the anti-Hp-IgG for 555 subjects in routine medical check-up. Results The results show ed that the PGI,PGII and G-17 level increased with age whereas PGI/PGII show ed a downw ard trend with age. For the Hp-positive group,the serum levels of PGI、PGII and G-17 were significantly higher than those of the Hp-negative group,while the PGI/PGII was significantly lower. Risk assessment of gastric disease were based on serum levels of PGI,PGII,G-17 and the anti-Hp-IgG : Group A included 354 people(63. 78%),Group B included 192 people(34. 59%),Group C included 9 people(1. 62%). Conclusion The serum level of PG and G-17 increased with age,as well as Hp infection. There were higher serum level of PG,abnormal G-17 and Hp infection rate in general population. We should provide stratified health management,and give active intervention and treatment.
引文
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[11]黄荣根,王春敏,黄飚.血清胃蛋白酶原检测用于健康体检的临床价值.中华全科医师杂志,2012,11(10):786-787.
[12]洪海鸥,张开光,常琳琳.体检人群胃泌素17检测及应用研究:中华医学会第六次全国健康管理学学术会议,中国北京,2014.
[13]Knekt P,Teppo L,Aromaa A,et al.Helicobacter pylori,Ig A and Ig G antibodies,serum pepsinogen I and the risk of gastric cancer:Changes in the risk with extended follow-up period.Int J Cancer,2006,119(3):702-705.
[14]Ricci C,Vakil N,Rugge M,et al.Serological markers for gastric atrophy in asymptomatic patients infected with Helicobacter pylori.Am J Gastroenterol,2004,99(10):1910-1915.
[15]黄荣根,宋晓华,王春敏,等.健康体检人群幽门螺杆菌感染程度与血清胃蛋白酶原水平的关系.标记免疫分析与临床,2013,20(4):203-206.
[16]车虎森,何雪琴,马荣光,等,胃疾病中血清胃蛋白酶原含量测定的应用价值.河北医药,2016,38(9):1388-1390.
[17]朱琦,熊华,张尧,等.Hp相关性胃部疾病患者Hp根除后血清胃泌素及胃蛋白酶原水平变化及临床意义.中国医学前沿杂志:电子版,2016,8(2):35-38.
[18]Coda S,Lee S Y,Gotoda T.Endoscopic mucosal resection and endoscopic submucosal dissection as treatments for early gastrointestinal cancers in Western countries.Gut Liver,2007,1(1):12-21.
[19]Park D I,Rhee P L,Kim J E,et al.Risk factors suggesting malignant transformation of gastric adenoma:univariate and multivariate analysis.Endoscopy,2001,33(6):501-506.
[20]Choi K D,Jung H Y,Lee G H,et al.Application of metal hemoclips for closure of endoscopic mucosal resection-induced ulcers of the stomach to prevent delayed bleeding.Surgical Endoscopy,2008,22(8):1882-1886.
[2]Sun L,Tu H,Liu J,et al.A comprehensive evaluation of fasting serum gastrin-17 as a predictor of diseased stomach in Chinese population.Scand J Gastroenterol,2014,49(10):1164-1172.
[3]Nakajima S.Gastric cancer screening in Japan,now and tomorrow.Nihon Rinsho,2012,70(10):1686-1693.
[4]席晓燕.上海体检人群胃蛋白酶原水平及与幽门螺杆菌感染的相关性.江苏预防医学,2015,26(1):32-34.
[5]Hmitsushima W.Predicting the development of gastric cancer from combining Helicobacter pylori antibodies and serum pepsinogen status:A prospective endoscopic cohort study.2005,54(6):764-768.
[6]张艺,张珏,严子禾,等.胃蛋白酶原、胰蛋白酶原-2、CEA、CA50、CA242在胃癌诊断中的应用价值分析.现代预防医学,2010,37(6):1116-1118.
[7]杨莉,孙明军,徐倩,等.血清胃蛋白酶原、促胃液素-17在慢性胃窦部萎缩性胃炎诊断中的价值.中华消化杂志,2014,34(7):478-480.
[8]李晓庆,郑奎城,林曙光,等.福建省沿海地区居民PG、G-17及H.pylori抗体血清流行病学调查.现代预防医学,2014,41(9):1543-1546.
[9]黄荣根,王春敏,黄飚,等.体检人群胃蛋白酶原水平分析及异常结果处理对策.标记免疫分析与临床,2012,19(2):71-74.
[10]林蔚,陈泽恒.3560例健康体检人群血清胃蛋白酶原检测结果分析.吉林医学,2015(14):3040-3041.
[11]黄荣根,王春敏,黄飚.血清胃蛋白酶原检测用于健康体检的临床价值.中华全科医师杂志,2012,11(10):786-787.
[12]洪海鸥,张开光,常琳琳.体检人群胃泌素17检测及应用研究:中华医学会第六次全国健康管理学学术会议,中国北京,2014.
[13]Knekt P,Teppo L,Aromaa A,et al.Helicobacter pylori,Ig A and Ig G antibodies,serum pepsinogen I and the risk of gastric cancer:Changes in the risk with extended follow-up period.Int J Cancer,2006,119(3):702-705.
[14]Ricci C,Vakil N,Rugge M,et al.Serological markers for gastric atrophy in asymptomatic patients infected with Helicobacter pylori.Am J Gastroenterol,2004,99(10):1910-1915.
[15]黄荣根,宋晓华,王春敏,等.健康体检人群幽门螺杆菌感染程度与血清胃蛋白酶原水平的关系.标记免疫分析与临床,2013,20(4):203-206.
[16]车虎森,何雪琴,马荣光,等,胃疾病中血清胃蛋白酶原含量测定的应用价值.河北医药,2016,38(9):1388-1390.
[17]朱琦,熊华,张尧,等.Hp相关性胃部疾病患者Hp根除后血清胃泌素及胃蛋白酶原水平变化及临床意义.中国医学前沿杂志:电子版,2016,8(2):35-38.
[18]Coda S,Lee S Y,Gotoda T.Endoscopic mucosal resection and endoscopic submucosal dissection as treatments for early gastrointestinal cancers in Western countries.Gut Liver,2007,1(1):12-21.
[19]Park D I,Rhee P L,Kim J E,et al.Risk factors suggesting malignant transformation of gastric adenoma:univariate and multivariate analysis.Endoscopy,2001,33(6):501-506.
[20]Choi K D,Jung H Y,Lee G H,et al.Application of metal hemoclips for closure of endoscopic mucosal resection-induced ulcers of the stomach to prevent delayed bleeding.Surgical Endoscopy,2008,22(8):1882-1886.