胃部疾病诊断中血清胃蛋白酶原检测的临床意义
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摘要
目的探究胃部疾病诊断中血清胃蛋白酶原检测的临床意义。方法选择2016年1月~2017年6月在我院接受治疗的胃部疾病患者,经病理检查及胃镜检查确诊胃癌患者43例(胃癌组),胃良性病变53例(胃良性病变组),选择同期在我院接受健康体检的正常志愿者45例作为对照组,抽血检验胃蛋白酶原(PGⅠ血清浓度、PGⅡ血清浓度,PGⅠ/PGⅡ比值),分析检测结果。结果胃癌组患者PGⅠ血清浓度显著低于为胃良性病变组(P<0.05);胃良性病变组PGⅡ血清浓度显著高于胃癌组(P<0.05);胃癌组检测血清PGI阳性率、PGⅠ/PGⅡ比值阳性率均显著高于良性病变组及对照组(P<0.05);胃癌组联合检测PGⅠ血清浓度、PGⅠ/PGⅡ比值阳性率显著高于胃良性病变组、对照组,数据差异具有统计学意义,P<0.05。结论胃部疾病诊断中检测血清胃蛋白酶原能够获得良好的临床价值。
Objective To explore the clinical significance of the detection of serum pepsinogen in the diagnosis of gastric disease. Methods From January 2016 to June 2017, the patients with gastric diseases who treated in our hospital were selected, 43 cases by pathological examination and gastroscopy confirmed gastric cancer(gastric cancer group), 53 cases of benign lesions(benign disease group), the same period in our hospital of normal health examination were selected as control group(45 cases), the blood pepsinogen(PGI serum concentration, serum PGⅡ concentration, PGI/PGII ratio) were inspected, the test results was analyzed. Results The serum concentration of PGⅠin patients of gastric cancer was significantly lower than that in gastric benign lesion group(P < 0.05). Serum PGⅡ concentration of benign gastric disease group was significantly higher than that in gastric cancer group(P < 0.05). The serum PGⅠ positive rate, ratio of PGⅠ/PGⅡ positive rate of gastric cancer group were significantly higher than those of the benign group and control group(P < 0.05).Serum PGI concentration, ratio of PGⅠ/PGⅡ positive rate of combined detection were significantly higher than those in benign gastric disease group and control group, difference with statistical significance(P < 0.05). Conclusion The detection of serum pepsinogen in the diagnosis of gastric disease can be of good clinical value.
Objective To explore the clinical significance of the detection of serum pepsinogen in the diagnosis of gastric disease. Methods From January 2016 to June 2017, the patients with gastric diseases who treated in our hospital were selected, 43 cases by pathological examination and gastroscopy confirmed gastric cancer(gastric cancer group), 53 cases of benign lesions(benign disease group), the same period in our hospital of normal health examination were selected as control group(45 cases), the blood pepsinogen(PGI serum concentration, serum PGⅡ concentration, PGI/PGII ratio) were inspected, the test results was analyzed. Results The serum concentration of PGⅠin patients of gastric cancer was significantly lower than that in gastric benign lesion group(P < 0.05). Serum PGⅡ concentration of benign gastric disease group was significantly higher than that in gastric cancer group(P < 0.05). The serum PGⅠ positive rate, ratio of PGⅠ/PGⅡ positive rate of gastric cancer group were significantly higher than those of the benign group and control group(P < 0.05).Serum PGI concentration, ratio of PGⅠ/PGⅡ positive rate of combined detection were significantly higher than those in benign gastric disease group and control group, difference with statistical significance(P < 0.05). Conclusion The detection of serum pepsinogen in the diagnosis of gastric disease can be of good clinical value.
引文
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[7]王雪萍,徐耀华.阿莫西林联合铋剂对慢性萎缩性胃炎患者血清胃泌素-17及胃蛋白酶原水平影响研究[J].中国生化药物杂志,2016,36(3):64-66.
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[9]唐光定,江伟河,黄海深.胃功能四项在胃部疾病和胃癌早期筛查中的应用研究[J].临床医学,2016,36(6):15-17.
[10]陈卿奇,羊文芳,吴素江,等.血清胃蛋白酶原及胃泌素-17水平与胃癌的相关性研究[J].重庆医学,2016,45(35):4938-4941,4944.
[11]韦志娟,张晓云.血清胃功能检测在早期胃癌筛查中的临床应用研究[J].国际检验医学杂志,2017,38(16):2240-2242.
[12]葛俊亮,陶绍能,阮昊,等.血清胃蛋白酶原在良恶性胃部疾病诊断中的临床应用[J].皖南医学院学报,2017,36,20(5):440-442.
[13]钱磊,陈为军.血清胃蛋白酶原在胃癌早期诊断中的应用意义及价值评析[J].中国实验诊断学,2016(2):243-245.
[14]刘烈辉,李捷壮.血清胃蛋白酶原联合高危人群胃镜检查幽门螺杆菌感染相关胃癌的价值[J].中国老年学杂志,2015,35(12):3392-3393.
[15]程桐花,朱桢祥.血清胃蛋白酶原和幽门螺杆菌Ig G抗体检测在胃癌及其癌前疾病筛查中的意义研究[J].安徽医药,2015,19(12):2354-2355,2356.
[2]孙鹏,毛朝明,蒋茜,等.胃部疾病患者组织和血清中白细胞介素23和胃蛋白酶原1的变化及临床意义[J].细胞与分子免疫学杂志,21016,32(4):523-526.
[3]陈湘林,朱净.胃蛋白酶原I联合胃蛋白酶原II检测在胃病中的临床应用价值分析[J].医学综述,2016,22(10):2006-2008.
[4]房国忠,吴红,杨琛.联合检测血清胃蛋白酶原和胸苷激酶1在胃部疾病诊断中的意义[J].现代检验医学杂志,2016,31(2):124-126.
[5]车虎森,何雪琴,马荣光,等.胃疾病中血清胃蛋白酶原含量测定的应用价值[J].河北医药,2016,38(9):1388-1390.
[6]黄荣根,颜兆寰,张梦千,等.健康体检人群胃部疾病相关血清学标志物含量分析及异常结果干预策略[J].标记免疫分析与临床,2017,24(2):154-158.
[7]王雪萍,徐耀华.阿莫西林联合铋剂对慢性萎缩性胃炎患者血清胃泌素-17及胃蛋白酶原水平影响研究[J].中国生化药物杂志,2016,36(3):64-66.
[8]宫月华.胃黏膜“血清学活检”指标的生理功能及调控[J].胃肠病学和肝病学杂志,2015,24(2):126-129.
[9]唐光定,江伟河,黄海深.胃功能四项在胃部疾病和胃癌早期筛查中的应用研究[J].临床医学,2016,36(6):15-17.
[10]陈卿奇,羊文芳,吴素江,等.血清胃蛋白酶原及胃泌素-17水平与胃癌的相关性研究[J].重庆医学,2016,45(35):4938-4941,4944.
[11]韦志娟,张晓云.血清胃功能检测在早期胃癌筛查中的临床应用研究[J].国际检验医学杂志,2017,38(16):2240-2242.
[12]葛俊亮,陶绍能,阮昊,等.血清胃蛋白酶原在良恶性胃部疾病诊断中的临床应用[J].皖南医学院学报,2017,36,20(5):440-442.
[13]钱磊,陈为军.血清胃蛋白酶原在胃癌早期诊断中的应用意义及价值评析[J].中国实验诊断学,2016(2):243-245.
[14]刘烈辉,李捷壮.血清胃蛋白酶原联合高危人群胃镜检查幽门螺杆菌感染相关胃癌的价值[J].中国老年学杂志,2015,35(12):3392-3393.
[15]程桐花,朱桢祥.血清胃蛋白酶原和幽门螺杆菌Ig G抗体检测在胃癌及其癌前疾病筛查中的意义研究[J].安徽医药,2015,19(12):2354-2355,2356.