正常妊娠中晚期胎儿甲状腺体积的超声检测及分析
|
摘要
目的利用三维超声检测妊娠中、晚期胎儿甲状腺的体积大小与孕周的关系,以超声辅助判定胎儿甲状腺的生长发育水平。方法选取进行产前检查的正常妊娠22~36周的健康孕妇100例,超声检测胎儿一般发育状况的同时应用三维超声计算机辅助分析(3DUS-VOCAL)技术检测胎儿甲状腺体积的大小,并评估胎儿甲状腺体积与孕周的相关性。结果妊娠中期与妊娠晚期胎儿的甲状腺体积差异有统计学意义,P<0.01。胎儿甲状腺体积随孕周的增加而增大,两者呈正相关关系,体积=-1.29+0.08GA(r=0.873,P<0.01)。结论三维超声检测妊娠中、晚期胎儿甲状腺体积大小有助于评估胎儿甲状腺的发育情况及早期诊断胎儿甲状腺异常,亦可随访判断作为宫内治疗是否有效的依据。
Objective Using three-dimensional ultrasound to evaluate the relationship between gestational age and fetal thyroid volume in normal second and third trimesters of pregnancy to help determine fetal thyroid growth and development. Methods Study objects included healthy pregnant women( n = 100),who had normal prenatal examination between 22 to 36 weeks of gestation. Ultrasound was performed to determine fetal general development situation and to detect fetal thyroid volume by using 3 DUS-VOCAL technology. Results There was a significant differences in thyroid volume( P < 0. 01). Fetal thyroid volume increased in association with the increase of gestational age during second and third trimesters of pregnancy,volume =-1. 29 + 0. 08 GA( r = 0. 873,P < 0. 01). Conclusion Three-dimensional ultrasonic testing of fetal thyroid volume during second and third trimesters of pregnancy helps evaluation of fetal thyroid development,early diagnosis of fetal thyroid abnormalities,as well as judgment of intrauterine treatment effect during follow-up.
Objective Using three-dimensional ultrasound to evaluate the relationship between gestational age and fetal thyroid volume in normal second and third trimesters of pregnancy to help determine fetal thyroid growth and development. Methods Study objects included healthy pregnant women( n = 100),who had normal prenatal examination between 22 to 36 weeks of gestation. Ultrasound was performed to determine fetal general development situation and to detect fetal thyroid volume by using 3 DUS-VOCAL technology. Results There was a significant differences in thyroid volume( P < 0. 01). Fetal thyroid volume increased in association with the increase of gestational age during second and third trimesters of pregnancy,volume =-1. 29 + 0. 08 GA( r = 0. 873,P < 0. 01). Conclusion Three-dimensional ultrasonic testing of fetal thyroid volume during second and third trimesters of pregnancy helps evaluation of fetal thyroid development,early diagnosis of fetal thyroid abnormalities,as well as judgment of intrauterine treatment effect during follow-up.
引文
[1]吴红花.2011年美国甲状腺学会“妊娠和产后甲状腺疾病诊断与治疗指南"摘编[J].中华围产医学杂志,2013,16(2):107-110.
[2]Fan JX,Yang S,Qian W,et al.Comparison of the reference intervals used for the evaluation of maternal thyroid function during pregnancy using sequential and nonsequential methods[J].Chin Med J(Engl),2016,129(7):785-791.
[3]陈倩.妊娠合并甲状腺功能亢进症对胎儿及新生儿的影响[J].中国实用妇科与产科杂志,2013,29(6):410-412.
[4]Luton D,Le Gac I,Vuillard E,et al.Management of Graves’disease during pregnancy:The key role of fetal thyroid gland monitoring[J].Clin Endocrinol Metab,2005,90(11):6093-6098.
[5]李敏,李丽雅,吕国荣.三维超声检测胎儿甲状腺体积[J].中国医学影像技术,2013,29(1):158-160.
[6]Lisandra SB,Rodrigo R,Andreia DS,et al.Nomograms of fetal thyroid measurements estimated by-dimensional sonography[J].Clin Utrasound,2008,36(4):193-199.
[7]凌乐文,吕国荣,苏珊珊,等.三维超声检测胎儿肺体积及其在常见胎儿肺病变随访中的应用[J].中国医学影像技术,2012,28(4):739-742.
[8]Virginie R,Mireille C,Anne-Marie B.Experience with Intraamniotic Thyroxine Treatment in Nonimmune Fetal Goitrous Hypothyroidism in 12 Cases[J].Clin Endocrinol Metab,2009,94(10):3731-3739.
[9]焦亚楼,高敏,张圣.妊娠期代谢性疾病对妊娠结局的影响[J].河北医药,2016,38(7):1072-1073.
[2]Fan JX,Yang S,Qian W,et al.Comparison of the reference intervals used for the evaluation of maternal thyroid function during pregnancy using sequential and nonsequential methods[J].Chin Med J(Engl),2016,129(7):785-791.
[3]陈倩.妊娠合并甲状腺功能亢进症对胎儿及新生儿的影响[J].中国实用妇科与产科杂志,2013,29(6):410-412.
[4]Luton D,Le Gac I,Vuillard E,et al.Management of Graves’disease during pregnancy:The key role of fetal thyroid gland monitoring[J].Clin Endocrinol Metab,2005,90(11):6093-6098.
[5]李敏,李丽雅,吕国荣.三维超声检测胎儿甲状腺体积[J].中国医学影像技术,2013,29(1):158-160.
[6]Lisandra SB,Rodrigo R,Andreia DS,et al.Nomograms of fetal thyroid measurements estimated by-dimensional sonography[J].Clin Utrasound,2008,36(4):193-199.
[7]凌乐文,吕国荣,苏珊珊,等.三维超声检测胎儿肺体积及其在常见胎儿肺病变随访中的应用[J].中国医学影像技术,2012,28(4):739-742.
[8]Virginie R,Mireille C,Anne-Marie B.Experience with Intraamniotic Thyroxine Treatment in Nonimmune Fetal Goitrous Hypothyroidism in 12 Cases[J].Clin Endocrinol Metab,2009,94(10):3731-3739.
[9]焦亚楼,高敏,张圣.妊娠期代谢性疾病对妊娠结局的影响[J].河北医药,2016,38(7):1072-1073.