五海瘿瘤丸联合微波消融术治疗乳房良性肿瘤临床研究
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摘要
目的探讨五海瘿瘤丸联合微波消融治疗乳房良性肿瘤的临床效果。方法选择我院2018年6月～2019年3月拟行乳腺微波消融术患者60例,随机分为对照组及观察组,各30例。对照组单纯采用微波消融术治疗,观察组在对照组基础上给予五海瘿瘤丸口服治疗,观察两组术后第3天不良反应发生情况、术后3个月临床疗效、中医临床症状积分情况及术后半年复发情况。结果术后第3天观察组不良反应发生率为11.63%,低于对照组的33.34%,差异具有统计学意义(P<0.05);观察组术后3个月的临床疗效为83.53%,高于对照组的47.37%,差异具有统计学意义(P<0.05);观察组中医临床症状积分改善率为64.36%,高于对照组的20.46%,差异具有统计学意义(P<0.05);观察组术后半年复发率为13.38%,低于对照组的40.56%,差异具有统计学意义(P<0.05)。结论五海瘿瘤丸联合微波消融治疗乳房良性肿瘤疗效显著,安全性高,复发率低,应用效果较好。
Objective To investigate the clinical effect of Wuhai Yingliu Pills combined with microwave ablation in the treatment of benign breast tumors. Methods 60 patients with breast microwave ablation from June 2018 to March 2019 were randomly divided into control group and observation group, 30 cases each. The control group was treated with microwave ablation alone. The observation group was given Wuhai Yingliu Pills on the basis of the control group. The adverse reactions occurred on the 3 rd day after operation, the clinical efficacy after 3 months, and the clinical symptom scores of TCM were observed. The situation and recurrence will be finding after half a year. Results On the third day after operation, the incidence of adverse reactions was 11.63%, lower than that of the control group which was 33.34%,the difference was statistically significant( P<0.05). The clinical effect of the observation group was 83.53% after 3 months, higher than the control group which was 47.37%,the difference was statistically significant( P<0.05);The improvement rate of clinical symptom scores in the observation group was 64.36%, higher than that in the control group which was 20.46%, the difference was statistically significant(P<0.05); The observation group recurrence rate was 13.38% in the group after operation, lower than that in the control group which was 40.56%,the difference was statistically significant(P <0.05). Conclusion Wuhai Yingliu Pills combined with microwave ablation is effective in the treatment of benign breast tumors with high safety, low recurrence rate and good application effect.
Objective To investigate the clinical effect of Wuhai Yingliu Pills combined with microwave ablation in the treatment of benign breast tumors. Methods 60 patients with breast microwave ablation from June 2018 to March 2019 were randomly divided into control group and observation group, 30 cases each. The control group was treated with microwave ablation alone. The observation group was given Wuhai Yingliu Pills on the basis of the control group. The adverse reactions occurred on the 3 rd day after operation, the clinical efficacy after 3 months, and the clinical symptom scores of TCM were observed. The situation and recurrence will be finding after half a year. Results On the third day after operation, the incidence of adverse reactions was 11.63%, lower than that of the control group which was 33.34%,the difference was statistically significant( P<0.05). The clinical effect of the observation group was 83.53% after 3 months, higher than the control group which was 47.37%,the difference was statistically significant( P<0.05);The improvement rate of clinical symptom scores in the observation group was 64.36%, higher than that in the control group which was 20.46%, the difference was statistically significant(P<0.05); The observation group recurrence rate was 13.38% in the group after operation, lower than that in the control group which was 40.56%,the difference was statistically significant(P <0.05). Conclusion Wuhai Yingliu Pills combined with microwave ablation is effective in the treatment of benign breast tumors with high safety, low recurrence rate and good application effect.
引文
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[2]中华人民共和国卫生部.中药新药临床研究指导原则[M].北京:中国中医药科技出版社,2002:228-229.
[3]王波,黄韵蓓,邓强.中医药外治烧烫伤的研究进展[J].中西医结合心血管电子杂志,2014,2(8):174.
[4]杨胜群,熊茜,邹俊波,等.中药在烧烫伤治疗中的应用及作用机制研究进展[J].中南药学,2015,13(11):1182-1186
[5]沈桢,阎皓.射频消融与微波消融治疗原发性小肝癌安全性、有效性及对免疫功能影响的对比研究[J].现代中西医结合杂志,2016,25(33):3659-3662.
[6]王龙琦,陈坚,刘绪舜.微波消融术与传统开放手术在良性甲状腺结节治疗中对机体创伤影响的比较[J].中国微创外科杂志,2016,16(3):236-240.
[7]吴元肇,曾勇,郑克思,等.夏枯草口服液对雌激素受体阳性乳腺癌细胞凋亡的影响[J].上海中医药大学学报,2016(2):78-81.
[8]叶晓丹.海带褐藻糖胶的提取及分离纯化及其生物活性的研究[D].福建师范大学,2016.