老年人牙周炎与慢性肾脏病相互促进的机制研究
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摘要
随着牙周医学的发展,关于牙周炎对全身健康影响的证据越来越多。牙周炎是牙菌斑微生物感染引发的慢性炎症性疾病,其致病微生物及毒性产物通过血液播散、引发宿主免疫应答等可能加剧了慢性肾病的发展,同时因患者患有慢性肾病,全身各项指标有所变化,进一步加剧了牙周疾病的发展。本文就慢性牙周炎与慢性肾病之间的关系作一综述。
With the development of periodontal medicine,there are more and more evidences about periodontitis affectedon general health.Periodontitis is a chronic inflammatory disease caused by dental plaque microorganisms' infection.Pathogenic microorganisms and toxic products may exacerbate the development of chronic kidney disease through blood distribution and triggering host immune responses.At thesame time,Physical indicators of patients withchronic kidney diseaseaggravatethe development of periodontal.This article reviews the relationship between periodontal disease and chronic kidney disease.
With the development of periodontal medicine,there are more and more evidences about periodontitis affectedon general health.Periodontitis is a chronic inflammatory disease caused by dental plaque microorganisms' infection.Pathogenic microorganisms and toxic products may exacerbate the development of chronic kidney disease through blood distribution and triggering host immune responses.At thesame time,Physical indicators of patients withchronic kidney diseaseaggravatethe development of periodontal.This article reviews the relationship between periodontal disease and chronic kidney disease.
引文
[1]宋佳,包穆蓉,潘亚萍,等.牙周健康自我评估在牙周炎流行病学调查中的应用[J].中华口腔医学杂志,2014,49(1):27-31.
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[4]魏习,胡波,彭海洋,等.血液透析患者龋病和牙周健康状况的系统评价[J].华西口腔医学杂志,2017,35(2):155-161.
[5]Kshirsagar AV,Moss KL,Eiter J R,et a1.Periodontal disease is associated with renal insuffi ciency in the Atheroscierosis Risk in Communities(ARIC)study[J].Am J Kidney Dis 2005 Apr:45(4):650-7.
[6]Fisher M A,Taylor T W,Shelton B J.Periodontal disease and other nontraditional risk factors for CKD[J].American journal of Kidney Diseases the official journal of Nation Kidney Foundation,2008,51(1):45.
[7]房付春.牙周炎对终末期肾脏病患者系统炎症、营养状况及脂质代谢水平的影响[D].广东:南方医科大学,2012.
[8]刘克瑾.慢性牙周炎严重程度的危险因素及与慢性肾脏疾病的相关性研究[D].广东:南方医科大学,2010.
[9]张鹏涛,钟良军.慢性牙周炎和慢性肾脏病与微炎症状态相关性研究进展[J].中华口腔医学研究杂志(电子版),2010,4(3):59-61.
[10]Chun YH,Chun KR,Olguin D.Biological foundation for periodontitis as apotential risk factor for atherosclerosis[J].J Periodontal Res,2005;40:87-95.
[11]Hung HC,Willett W,Merchant A.Oral health and peripheral arterialDisease[J].Circulation,2003;107:1152-7.
[12]Panichi V,Maggiore U,Taccola D,et al.Interleukin-6 is a stronger predictor of total and cardiovascular mortality than C-reactive protein in haemodialysis patients[J].Nephrol Dial Transplant,2004,19(5):1154-1160.
[13]Wang CH,Li SH,Weisel RD.C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle[J].Circulation,2003;107:1783-90.
[14]张东,李晶,秦猛.老年牙周病与心血管疾病互为诱因的机制探讨[J].中国老年学杂志,2016,36(10),2553-2555.
[15]ChenLP,ChiangCK,ChanCP,et a1.Does periodontitis refl ect inflammation and malnutrition status in hemodialysis patients?[J].Am J Kidney Dis,2006,47(5):815-822
[16]Vaziri ND,Pahl MV,Crum A,et al.Effect of uremia onstructure and function of immune system[J].J Ren Nutr,2012,22(1):149-156.
[17]王勤涛.牙周病学[M].2版.北京:人民卫生出版社,2011:72-78.
[18]Damm DD,Neville BW,McKenna S,et al.Macrognathia of renal osteodystrophy in dialysis patients[J].Oral SurgOralMed Oral Pathol Oral RadiolEndod,1997,83(4):489-495.
[19]Sakallio?lu EE,Lutfi o?lu M,Ozkaya O,et a1.Fluid dynamics of gingiva and gingival health in children with end stage renalfailure[J].Arch Oral Biol,2007,52(12):1194-1199.
[2]刘聪,王婷,张天夫,等.牙周病与慢性肾病相关性的Meta分析[J].中国实验诊断学,2016,20(12):2087-2090.
[3]Levey AS,Eckardt K U,Tsukampto Y,et a1.Defi niotion and classification of chronic kidney disease:A position of on statement from kidney disease:Improving Global Outcomes(KDIGO)[J].Kidney International,2005,67(6):2089.
[4]魏习,胡波,彭海洋,等.血液透析患者龋病和牙周健康状况的系统评价[J].华西口腔医学杂志,2017,35(2):155-161.
[5]Kshirsagar AV,Moss KL,Eiter J R,et a1.Periodontal disease is associated with renal insuffi ciency in the Atheroscierosis Risk in Communities(ARIC)study[J].Am J Kidney Dis 2005 Apr:45(4):650-7.
[6]Fisher M A,Taylor T W,Shelton B J.Periodontal disease and other nontraditional risk factors for CKD[J].American journal of Kidney Diseases the official journal of Nation Kidney Foundation,2008,51(1):45.
[7]房付春.牙周炎对终末期肾脏病患者系统炎症、营养状况及脂质代谢水平的影响[D].广东:南方医科大学,2012.
[8]刘克瑾.慢性牙周炎严重程度的危险因素及与慢性肾脏疾病的相关性研究[D].广东:南方医科大学,2010.
[9]张鹏涛,钟良军.慢性牙周炎和慢性肾脏病与微炎症状态相关性研究进展[J].中华口腔医学研究杂志(电子版),2010,4(3):59-61.
[10]Chun YH,Chun KR,Olguin D.Biological foundation for periodontitis as apotential risk factor for atherosclerosis[J].J Periodontal Res,2005;40:87-95.
[11]Hung HC,Willett W,Merchant A.Oral health and peripheral arterialDisease[J].Circulation,2003;107:1152-7.
[12]Panichi V,Maggiore U,Taccola D,et al.Interleukin-6 is a stronger predictor of total and cardiovascular mortality than C-reactive protein in haemodialysis patients[J].Nephrol Dial Transplant,2004,19(5):1154-1160.
[13]Wang CH,Li SH,Weisel RD.C-reactive protein upregulates angiotensin type 1 receptors in vascular smooth muscle[J].Circulation,2003;107:1783-90.
[14]张东,李晶,秦猛.老年牙周病与心血管疾病互为诱因的机制探讨[J].中国老年学杂志,2016,36(10),2553-2555.
[15]ChenLP,ChiangCK,ChanCP,et a1.Does periodontitis refl ect inflammation and malnutrition status in hemodialysis patients?[J].Am J Kidney Dis,2006,47(5):815-822
[16]Vaziri ND,Pahl MV,Crum A,et al.Effect of uremia onstructure and function of immune system[J].J Ren Nutr,2012,22(1):149-156.
[17]王勤涛.牙周病学[M].2版.北京:人民卫生出版社,2011:72-78.
[18]Damm DD,Neville BW,McKenna S,et al.Macrognathia of renal osteodystrophy in dialysis patients[J].Oral SurgOralMed Oral Pathol Oral RadiolEndod,1997,83(4):489-495.
[19]Sakallio?lu EE,Lutfi o?lu M,Ozkaya O,et a1.Fluid dynamics of gingiva and gingival health in children with end stage renalfailure[J].Arch Oral Biol,2007,52(12):1194-1199.