穴位贴敷联合化瘀复明汤治疗糖尿病视网膜病变临床研究
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摘要
目的:观察穴位贴敷联合化瘀复明汤治疗糖尿病视网膜病变的临床疗效。方法:选取86例糖尿病视网膜病变患者为研究对象,随机分为对照组与观察组各43例。2组均给予糖尿病基础治疗,对照组给予羟苯磺酸钙胶囊口服,观察组在对照组基础上增加穴位贴敷联合化瘀复明汤口服。连续治疗2个月后对2组临床疗效、视力恢复情况、视网膜中央动脉血流动力学指标、不良反应发生率进行统计,并进行组间比较。结果:观察组总有效率93.02%,高于对照组的76.74%,差异有统计学意义(P <0.05)。治疗后,2组视力及平均光敏感度均较治疗前升高(P <0.05),视野损害评分及黄斑厚度均较治疗前降低(P <0.05);观察组视力及平均光敏感度均高于对照组(P <0.05),视野损害评分及黄斑厚度均低于对照组(P <0.05)。治疗后,2组视网膜中央动脉血流动力学参数[收缩期峰值流速(PSV)、舒张末期流速(EDV)]均较治疗前提升(P <0.05),阻力指数(RI)均较治疗前降低(P <0.05);观察组PSV、EDV快于对照组(P <0.05),RI低于对照组(P <0.05)。观察组不良反应发生率18.60%,对照组不良反应发生率9.30%,2组比较,差异无统计学意义(P> 0.05)。结论:穴位贴敷联合化瘀复明汤治疗糖尿病视网膜病变,能有效改善患者的症状、视力水平和视网膜中央动脉血流动力学指标。
Objective:To observe the clinical effect of point application combined with Huayu Fuming tang in the treatment of diabetic retinopathy. Methods:A total of 86 patients with diabetic retinopathy were selected as subjects,divided into the control group and the observation group,43 case in each group. The two groups were given basic treatment for diabetes;the control group was treated with Calcium Dobesilate capsules orally, and the observation group was additionally given point application combined with Huayu Fuming tang orally based on the treatment of the control group. After two-month treatment,the clinical effect, the vision recovery, the hemodynamic parameters of central retinal artery and the incidence of adverse reactions in the two groups were statistically analyzed and compared between the two groups. Results: The total effective rate in the observation group was 93.02%,higher than that in the control group(76.74%),the difference being significant(P <0.05). After treatment, the vision and average light sensitivity in both groups were increased when compared with those before treatment(P < 0.05),and the score of visual field damage and the thickness of macula were decreased when compared with those before treatment(P < 0.05). The vision and average light sensitivity in the observation group were higher than those in the control group(P < 0.05),and the score of visual field damage and the thickness of macula were lower than those in the control group(P < 0.05). After treatment,the hemodynamic parameters of central retinal artery including peak systolic velocity(PSV) and end diastolic velocity(EDV) in both groups were increased when compared with those before treatment(P < 0.05),and the resistance index(RI) was decreased when compared with that before treatment(P < 0.05). The PSV and EDV in the observation group were faster than those in the control group(P < 0.05),and RI was lower than that in the control group(P <0.05). The incidence of adverse reactions was 18.60% in the observation group and 9.30% in the control group,there beingno significant difference between the two groups(P > 0.05). Conclusion:The therapy of point application combined with Huayu Fuming tang in the treatment of diabetic retinopathy can effectively improve the symptoms, vision and hemodynamic parameters of central retinal artery of patients.
Objective:To observe the clinical effect of point application combined with Huayu Fuming tang in the treatment of diabetic retinopathy. Methods:A total of 86 patients with diabetic retinopathy were selected as subjects,divided into the control group and the observation group,43 case in each group. The two groups were given basic treatment for diabetes;the control group was treated with Calcium Dobesilate capsules orally, and the observation group was additionally given point application combined with Huayu Fuming tang orally based on the treatment of the control group. After two-month treatment,the clinical effect, the vision recovery, the hemodynamic parameters of central retinal artery and the incidence of adverse reactions in the two groups were statistically analyzed and compared between the two groups. Results: The total effective rate in the observation group was 93.02%,higher than that in the control group(76.74%),the difference being significant(P <0.05). After treatment, the vision and average light sensitivity in both groups were increased when compared with those before treatment(P < 0.05),and the score of visual field damage and the thickness of macula were decreased when compared with those before treatment(P < 0.05). The vision and average light sensitivity in the observation group were higher than those in the control group(P < 0.05),and the score of visual field damage and the thickness of macula were lower than those in the control group(P < 0.05). After treatment,the hemodynamic parameters of central retinal artery including peak systolic velocity(PSV) and end diastolic velocity(EDV) in both groups were increased when compared with those before treatment(P < 0.05),and the resistance index(RI) was decreased when compared with that before treatment(P < 0.05). The PSV and EDV in the observation group were faster than those in the control group(P < 0.05),and RI was lower than that in the control group(P <0.05). The incidence of adverse reactions was 18.60% in the observation group and 9.30% in the control group,there beingno significant difference between the two groups(P > 0.05). Conclusion:The therapy of point application combined with Huayu Fuming tang in the treatment of diabetic retinopathy can effectively improve the symptoms, vision and hemodynamic parameters of central retinal artery of patients.
引文
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[4]戴淑香.耳穴贴压联合中药离子导入治疗糖尿病视网膜病变(气虚血瘀型)的临床观察[J].中华临床医师杂志(电子版),2016,23(7):113-114.
[5]周秀芹.羟苯磺酸钙胶囊在糖尿病视网膜病变患者中的应用[J].当代医学,2011,17(4):146.
[6]庄枫.2型糖尿病视网膜病变的“血瘀”病机辨识及其相关因素临床研究[D].南京:南京中医药大学,2016.
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[2]中华医学会眼科学会眼底病学组.我国糖尿病视网膜病变临床诊疗指南(2014年)[J].中华眼科杂志,2014,50(11):851-865.
[3]赵建浩.中医眼科学[M].北京:科学出版社,2000:156-159.
[4]戴淑香.耳穴贴压联合中药离子导入治疗糖尿病视网膜病变(气虚血瘀型)的临床观察[J].中华临床医师杂志(电子版),2016,23(7):113-114.
[5]周秀芹.羟苯磺酸钙胶囊在糖尿病视网膜病变患者中的应用[J].当代医学,2011,17(4):146.
[6]庄枫.2型糖尿病视网膜病变的“血瘀”病机辨识及其相关因素临床研究[D].南京:南京中医药大学,2016.
[7]牟洪林.中医治疗糖尿病眼病[M].天津:天津科技翻译出版有限公司,2013:128.