血清INHB、IGF-1、VEGF、E2在多囊卵巢综合征患者中的表达及临床意义
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摘要
目的探讨血清抑制素B(INHB)、类胰岛素样生长因子1(IGF-1)、血管内皮生长因子(VEGF)及雌二醇(E2)在多囊卵巢综合征(PCOS)患者中的表达及临床意义。方法选择2015年4月至2016年5月该院接诊的45例PCOS患者作为观察组,另选择同期因男方因素不孕而进行体检的健康女性45例作为对照组。分析血清INHB、IGF-1、VEGF、E2在PCOS中的表达意义及诊断价值。结果观察组患者血清INHB、IGF-1、VEGF、E2水平均高于对照组,差异均有统计学意义(P<0.05);INHB、IGF-1、VEGF、E2诊断PCOS的受试者工作特征曲线(ROC曲线)曲线下面积(AUC)分别为0.935、0.988、0.992、0.759,诊断PCOS的灵敏度分别为80.93%、81.18%、79.12%、79.07%,特异度分别为73.05%、75.17%、77.49%、78.59%。结论血清INHB、IGF-1、VEGF、E2在PCOS患者中呈高表达,可作为诊断PCOS的重要指标。
Objective To study the expression and significance of serum inhibin B(INHB),insulin-like growth factor-1(IGF-1),vascular endothelial growth factor(VEGF)and estradiol(E2)in patients with polycystic ovary syndrome(PCOS).Methods A total of 45 patients with PCOS in the hospital from April 2015 to May 2016,were selected as observation group.In addition,45 healthy women who underwent physical examination due to male infertility were selected as control group.The significance and diagnostic value of serum INHB,IGF-1,VEGF and E2 in PCOS were analyzed.Results The levels of serum INHB,IGF-1,VEGF and E2 in observation group were significantly higher than those of control group(P<0.05).The receiver operating characteristic curve(ROC curve)analysis showed that the AUC of INHB,IGF-1,VEGF and E2 were 0.935,0.988,0.992 and 0.759,respectively.The sensitivity of PCOS were 80.93%,81.18%,79.12% and79.07%,while the specificity of PCOS were 73.05%,75.17%,77.49% and 78.59%,respectively.Conclusion Serum INHB,IGF-1,VEGF and E2 are highly expressed in patients with PCOS,which can be used as an important indicators in the diagnosis of PCOS.
Objective To study the expression and significance of serum inhibin B(INHB),insulin-like growth factor-1(IGF-1),vascular endothelial growth factor(VEGF)and estradiol(E2)in patients with polycystic ovary syndrome(PCOS).Methods A total of 45 patients with PCOS in the hospital from April 2015 to May 2016,were selected as observation group.In addition,45 healthy women who underwent physical examination due to male infertility were selected as control group.The significance and diagnostic value of serum INHB,IGF-1,VEGF and E2 in PCOS were analyzed.Results The levels of serum INHB,IGF-1,VEGF and E2 in observation group were significantly higher than those of control group(P<0.05).The receiver operating characteristic curve(ROC curve)analysis showed that the AUC of INHB,IGF-1,VEGF and E2 were 0.935,0.988,0.992 and 0.759,respectively.The sensitivity of PCOS were 80.93%,81.18%,79.12% and79.07%,while the specificity of PCOS were 73.05%,75.17%,77.49% and 78.59%,respectively.Conclusion Serum INHB,IGF-1,VEGF and E2 are highly expressed in patients with PCOS,which can be used as an important indicators in the diagnosis of PCOS.
引文
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[10]刘小惠,吴小华.抑制素B在两性生殖生理和病理中的研究进展[J].生殖与避孕,2016,36(9):737-744.
[11]刘小惠,吴小华.胰岛素样生长因子-1与促排卵结局及抑制素B、血管内皮生长因子的相关研究[J].生殖医学杂志,2018,27(2):123-129.
[12]李凤巧.IGF-1、IGFBP-1的检测对PCOS不孕的表达[J].世界最新医学信息文摘,2015,15(22):134-135.
[13]刘梅梅,丁慧,尹晓静,等.多囊卵巢综合征患者血清血管内皮生长因子、内皮抑素水平及对卵巢间质血流的影响研究[J].中国全科医学,2017,20(4):448-453.
[14]刘小惠,吴小华.血管内皮生长因子在女性生殖生理和病理中的研究进展[J].现代妇产科进展,2017,26(3):231-234.
[15]VITAL-REYES V S,LOPEZ-ALARCN M G,INDAICAZA P,et al.Subtle metabolic alterations in adolescents with obesity and polycystic ovarian syndrome[J].Gac Med Mex,2017,153(Suppl 2):S34-41.
[16]TESSARO I,MODINA S,LODDE V,et al.Ultra-low doses of follicle stimulating hormone and progesterone attenuate the severity of polycystic ovary syndrome features in a hyperandrogenized mouse model[J].J Reprod Infertil,2017,18(3):288-297.
[2]陈晓红,徐彩生,刘璇芝.胰岛素抵抗对多囊卵巢综合征患者血清性激素水平的影响[J].山东医药,2015,55(14):50-51.
[3] NAJI M,ALEYASIN A,NEKOONAM S,et al.Differential expression of miR-93and miR-21in granulosa cells and follicular fluid of polycystic ovary syndrome associating with different phenotypes[J].Sci Rep,2017,7(1):14671.
[4]宋梦玲,王飞苗,李彩艳,等.血清及卵泡液中肝素结合性表皮生长因子水平与多囊卵巢综合征关系的研究[J].实用妇产科杂志,2015,31(7):508-511.
[5]艾风连,徐玉萍,赵林海,等.多囊卵巢综合征患者促甲状腺素浓度与性激素、胰岛素抵抗及血脂关系的分析[J].生殖与避孕,2015,35(7):463-467.
[6]李莹,聂明月,方颖,等.多囊卵巢综合征患者控制性超促排卵过程AMH和INHB浓度变化的临床研究[J].首都医科大学学报,2014,35(4):402-406.
[7]应露,应晓莹,施丽,等.中药瓜石汤联合来曲唑对多囊卵巢综合征不孕患者LH、FSH及E2的影响[J].中国生化药物杂志,2016,36(3):113-115.
[8] ZHENG Q,LI Y,ZHANG D,et al.ANP promotes proliferation and inhibits apoptosis of ovarian granulosa cells by NPRA/PGRMC1/EGFR complex and improves ovary functions of PCOS rats[J].Cell Death Dis,2017,8(10):e3145.
[9]杨琪,夏天,李爽,等.血清抑制素B对女性生殖功能的临床诊断价值[J].中国妇产科临床杂志,2016,17(2):187-189.
[10]刘小惠,吴小华.抑制素B在两性生殖生理和病理中的研究进展[J].生殖与避孕,2016,36(9):737-744.
[11]刘小惠,吴小华.胰岛素样生长因子-1与促排卵结局及抑制素B、血管内皮生长因子的相关研究[J].生殖医学杂志,2018,27(2):123-129.
[12]李凤巧.IGF-1、IGFBP-1的检测对PCOS不孕的表达[J].世界最新医学信息文摘,2015,15(22):134-135.
[13]刘梅梅,丁慧,尹晓静,等.多囊卵巢综合征患者血清血管内皮生长因子、内皮抑素水平及对卵巢间质血流的影响研究[J].中国全科医学,2017,20(4):448-453.
[14]刘小惠,吴小华.血管内皮生长因子在女性生殖生理和病理中的研究进展[J].现代妇产科进展,2017,26(3):231-234.
[15]VITAL-REYES V S,LOPEZ-ALARCN M G,INDAICAZA P,et al.Subtle metabolic alterations in adolescents with obesity and polycystic ovarian syndrome[J].Gac Med Mex,2017,153(Suppl 2):S34-41.
[16]TESSARO I,MODINA S,LODDE V,et al.Ultra-low doses of follicle stimulating hormone and progesterone attenuate the severity of polycystic ovary syndrome features in a hyperandrogenized mouse model[J].J Reprod Infertil,2017,18(3):288-297.