胱抑素C与同型半胱氨酸在糖尿病周围神经病变中的研究进展
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摘要
胱抑素C(CysC)属半胱氨酸类,可抑制半胱氨酸酶活性。同型半胱氨酸(Hcy)为一种α氨基酸,是蛋氨酸转甲基后生成的中间代谢产物。CysC与Hcy呈正相关,可通过氧化应激、促炎性反应、干扰凝血平衡等损伤微血管,并与微血管病变存在独立关联。糖尿病周围神经病变(DPN)与糖尿病微血管病变之间存在相关性,诸多学者也尝试通过循证医学研究揭示Hcy、CysC与DPN的关系,力争为DPN找到更多血清学依据,为其诊断、治疗以及预后监测提供可靠指标。
Cystatin C( CysC) is a member of cysteine category and can inhibit cysteine enzyme activity. Homocysteine( Hcy) is an α amino acid,which is an intermediate metabolite produced after methionine is converted to methyl. Studies have shown that CysC and Hcy have a positive correlation. Previous studies have found that CysC and Hcy can damage microvasculature through oxidative stress,pro-inflammatory reaction and interference with coagulation balance. CysC and Hcy have an independent correlation with microvascular lesions. There is a correlation between diabetic peripheral neuropathy( DPN) and diabetic microangiopathy. Many scholars have also tried to reveal the relationship between Hcy,CysC and DPN through evidence-based medicine research,and strive to find more serological evidence for DPN and provide reliable indicators for its diagnosis,treatment and prognosis monitoring.
Cystatin C( CysC) is a member of cysteine category and can inhibit cysteine enzyme activity. Homocysteine( Hcy) is an α amino acid,which is an intermediate metabolite produced after methionine is converted to methyl. Studies have shown that CysC and Hcy have a positive correlation. Previous studies have found that CysC and Hcy can damage microvasculature through oxidative stress,pro-inflammatory reaction and interference with coagulation balance. CysC and Hcy have an independent correlation with microvascular lesions. There is a correlation between diabetic peripheral neuropathy( DPN) and diabetic microangiopathy. Many scholars have also tried to reveal the relationship between Hcy,CysC and DPN through evidence-based medicine research,and strive to find more serological evidence for DPN and provide reliable indicators for its diagnosis,treatment and prognosis monitoring.
引文
[1]Tesfaye S,Selvarajah D. Advances in the epidemiology,pathogenesis and management of diabetic peripheral neuropathy[J].Diabetes Metab Res Rev,2012,28 Suppl 1:8-14.
[2]Charles M,Ejskjaer N,Witte DR,et al. Prevalence of neuropathy and peripheral arterial disease and the impact of treatment in people with screen-detected type 2 diabetes:The ADDITIONDenmark study[J]. Diabetes Care,2011,34(10):2244-2249.
[3]Zheng C,Ou W,Shen H,et al. Combined therapy of diabetic peripheral neuropathy with breviscapine and mecobalamin:A systematic review and a meta-analysis of Chinese studies[J]. Biomed Res Int,2015,2015:680756.
[4]赵志刚.糖尿病周围神经病变的临床筛查研究[C]//中华医学会糖尿病分会.中华医学会糖尿病学分会.第十六次全国学术会议论文集,北京,2012.北京:中华医学会杂志社,2012:2.
[5]Ennis SL,Galea MP,O'Neal DN,et al. Peripheral neuropathy in the hands of people with diabetes mellitus[J]. Diabetes Res Clin Pract,2016,119:23-31.
[6]Uccioli L,Izzo V,Meloni M,et al. Non-healing foot ulcers in diabetic patients:General and local interfering conditions and management options with advanced wound dressings[J]. J Wound Care,2015,24(4 Suppl):35-42.
[7]Ashjazadeh N,Fathi M,Shariat A. Evaluation of Homocysteine Level as a Risk Factor among Patients with Ischemic Stroke and Its Subtypes[J]. Iran J Med Sci,2013,38(3):233-239.
[8]de Luis DA,Fernandez N,Arranz ML,et al. Total homocysteine levels relation with chronic complications of diabetes,body composition,and other cardiovascular risk factors in a population of patients with diabetes mellitus type 2[J]. J Diabetes Complications,2005,19(1):42-46.
[9]Li S,Tang X,Peng L,et al. A head-to-head comparison of homocysteine and cystatin C as pre-procedure predictors for contrastinduced nephropathy in patients undergoing coronary computed tomography angiography[J]. Clin Chim Acta,2015,444:86-91.
[10]周明锴,程倚萌.急性脑梗死患者血清同型半胱氨酸与胱抑素C水平相关性分析[J].中国实用神经疾病杂志,2013,16(5):24-25.
[11]Fu Z,Yang X,Shen M,et al. Prognostic ability of cystatin C and homocysteine plasma levels for long-term outcomes in very old acute myocardial infarction patients[J]. Clin Interv Aging,2018,13:1201-1209.
[12]Lee SH,Park SA,Ko SH,et al. Insulin resistance and inflammation may have an additional role in the link between cystatin C and cardiovascular disease in type 2 diabetes mellitus patients[J]. Metabolism,2010,59(2):241-246.
[13]聂伟明,彭易清,朱进成. Hcy与Cys C联合检测在2型糖尿病并发症中的应用价值[J].国际检验医学杂志,2017,38(24):3474-3476.
[14]秦淑国,胡恒贵,邵从军,等. FA、Vit B6、Hcy和Cys C与糖尿病肾病病变程度的相关性分析[J].检验医学与临床,2018,15(16):2371-2373.
[15]Chowdhury SR.血清胱抑素、C反应蛋白和同型半胱氨酸作为生物标志物在2型糖尿病视网膜病变中的作用[D].济南:山东大学,2016.
[16]袁娟.糖尿病周围神经病变患者血浆Hcy和Cys-C水平变化及意义[J].中国实验诊断学,2015,19(12):2119-2121.
[17]陈德鹏.血浆同型半胱氨酸和胱抑素C与糖尿病周围神经病变的相关性研究[J].中国糖尿病杂志,2014,22(12):1071-1074.
[18]Bruce SG,Young TK. Prevalence and risk factors for neuropathy in a Canadian First Nation community[J]. Diabetes Care,2008,31(9):1837-1841.
[19]Wang T,Wang Q,Wang Z,et al. Diagnostic value of the combined measurement of serum hcy,serum cys C,and urinary microalbumin in type 2 diabetes mellitus with early complicating diabetic nephropathy[J]. ISRN Endocrinol,2013,2013:407452.
[20]Zheng LQ,Zhang HL,Guan ZH,et al. Elevated serum homocysteine level in the development of diabetic peripheral neuropathy[J]. Genet Mol Res,2015,14(4):15365-15375.
[21]Leishear K,Ferrucci L,Lauretani F,et al. Vitamin B12 and homocysteine levels and 6-year change in peripheral nerve function and neurological signs[J]. J Gerontol A Biol Sci Med Sci,2012,67(5):537-543.
[22]陈福莲,陈澎,王萌. 2型糖尿病患者血浆同型半胱氨酸与神经传导异常的关系[J].中国医师进修杂志,2012,35(10):64-65,70.
[23]罗宇.血清同型半胱氨酸水平与糖尿病周围神经病变病情的相关性研究[J].中国社区医师(医学专业),2013,15(3):185.
[24]González R,Pedro T,Martinez-Hervas S,et al. Plasma homocysteine levels are independently associated with the severity of peripheral polyneuropathy in type 2 diabetic subjects[J]. J Peripher Nerv Syst,2012,17(2):191-196.
[25]彭少林,沙永红,张美彪,等.糖尿病周围神经病变患者血清C肽与同型半胱氨酸、胱抑素C的相关性研究[J].社区医学杂志,2018,16(7):57-59.
[26]董燕燕,陈光亮.高同型半胱氨酸血症危害及致病机制研究进展[J].中国药理学通报,2014,30(9):1205-1208.
[27]Marsillach J,Suzuki SM,Richter RJ,et al. Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase[J]. PLo S One,2014,9(10):e110054.
[28]Sato Y,Ouchi K,Funase Y,et al. Relationship between metformin use,vitamin B12deficiency,hyperhomocysteinemia and vascular complications in patients with type 2 diabetes[J]. Endocr J,2013,60(12):1275-1280.
[29]晏丕军,张志红,徐勇,等. 2型糖尿病患者血清胱抑素C水平与振动感觉阈值的关系[J].中南大学学报(医学版),2016,41(1):58-64.
[30]Barbarash OL,Bykova IS,Kashtalap VV,et al. Serum neutrophil gelatinase-associated lipocalin has an advantage over serum cystatin C and glomerular filtration rate in prediction of adverse cardiovascular outcome in patients with ST-segment elevation myocardial infarction[J]. BMC Cardiovasc Disord,2017,17(1):81.
[31]闫萌萌,刘素筠,卓小群.胱抑素C与2型糖尿病视网膜病变的相关性研究[J].中国药物与临床,2015,5(1):128-129.
[32]Kasai H,Tsuji Y,Hiraki Y,et al. Population pharmacokinetics of teicoplanin in hospitalized elderly patients using cystatin C as an indicator of renal function[J]. J Infect Chemother,2018,24(4):284-291.
[33]Karlberg C,Falk C,Green A,et al. Proliferative retinopathy predicts nephropathy:A 25-year follow-up study of type 1 diabetic patients[J]. Acta Diabetol,2012,49(4):263-268.
[34]Chung JO,Cho DH,Chung DJ,et al. Serum Cystatin C Levels are Positively Associated with Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes[J]. Exp Clin Endocrinol Diabetes,2015,123(10):627-631.
[35]Ai L,Hu Y,Zhang X,et al. High cystatin C levels predict undesirable outcome for diabetic foot ulcerations[J]. Wound Repair Regen,2016,24(3):560-567.
[36]赵蔚菁,李连喜,刘风静,等.血清胱抑素C与2型糖尿病并发症的相关性研究[J].中国临床医学,2013,20(6):768-771.
[37]Hu Y,Liu F,Shen J,et al. Association between serum cystatin C and diabetic peripheral neuropathy:A cross-sectional study of a Chinese type 2 diabetic population[J]. Eur J Endocrinol,2014,171(5):641-648.
[38]罗璇,韦少恒.血清标志物与糖尿病周围神经病变的相关性[J].检验医学与临床,2017,14(14):2091-2093.
[39]陈兰英,郑芬萍,李红. 2型糖尿病周围神经病变患者血清胱抑素C水平及其临床意义[J].中国糖尿病杂志,2014,22(8):700-703.
[40]Tsai HT,Wang PH,Tee YT,et al. Imbalanced serum concentration between cathepsin B and cystatin C in patients with pelvic inflammatory disease[J]. Fertil Steril,2009,91(2):549-555.
[41]Eriksson P,Deguchi H,Samneg?rd A,et al. Human evidence that the cystatin C gene is implicated in focal progression of coronary artery disease[J]. Arterioscler Thromb Vasc Biol,2004,24(3):551-557.
[2]Charles M,Ejskjaer N,Witte DR,et al. Prevalence of neuropathy and peripheral arterial disease and the impact of treatment in people with screen-detected type 2 diabetes:The ADDITIONDenmark study[J]. Diabetes Care,2011,34(10):2244-2249.
[3]Zheng C,Ou W,Shen H,et al. Combined therapy of diabetic peripheral neuropathy with breviscapine and mecobalamin:A systematic review and a meta-analysis of Chinese studies[J]. Biomed Res Int,2015,2015:680756.
[4]赵志刚.糖尿病周围神经病变的临床筛查研究[C]//中华医学会糖尿病分会.中华医学会糖尿病学分会.第十六次全国学术会议论文集,北京,2012.北京:中华医学会杂志社,2012:2.
[5]Ennis SL,Galea MP,O'Neal DN,et al. Peripheral neuropathy in the hands of people with diabetes mellitus[J]. Diabetes Res Clin Pract,2016,119:23-31.
[6]Uccioli L,Izzo V,Meloni M,et al. Non-healing foot ulcers in diabetic patients:General and local interfering conditions and management options with advanced wound dressings[J]. J Wound Care,2015,24(4 Suppl):35-42.
[7]Ashjazadeh N,Fathi M,Shariat A. Evaluation of Homocysteine Level as a Risk Factor among Patients with Ischemic Stroke and Its Subtypes[J]. Iran J Med Sci,2013,38(3):233-239.
[8]de Luis DA,Fernandez N,Arranz ML,et al. Total homocysteine levels relation with chronic complications of diabetes,body composition,and other cardiovascular risk factors in a population of patients with diabetes mellitus type 2[J]. J Diabetes Complications,2005,19(1):42-46.
[9]Li S,Tang X,Peng L,et al. A head-to-head comparison of homocysteine and cystatin C as pre-procedure predictors for contrastinduced nephropathy in patients undergoing coronary computed tomography angiography[J]. Clin Chim Acta,2015,444:86-91.
[10]周明锴,程倚萌.急性脑梗死患者血清同型半胱氨酸与胱抑素C水平相关性分析[J].中国实用神经疾病杂志,2013,16(5):24-25.
[11]Fu Z,Yang X,Shen M,et al. Prognostic ability of cystatin C and homocysteine plasma levels for long-term outcomes in very old acute myocardial infarction patients[J]. Clin Interv Aging,2018,13:1201-1209.
[12]Lee SH,Park SA,Ko SH,et al. Insulin resistance and inflammation may have an additional role in the link between cystatin C and cardiovascular disease in type 2 diabetes mellitus patients[J]. Metabolism,2010,59(2):241-246.
[13]聂伟明,彭易清,朱进成. Hcy与Cys C联合检测在2型糖尿病并发症中的应用价值[J].国际检验医学杂志,2017,38(24):3474-3476.
[14]秦淑国,胡恒贵,邵从军,等. FA、Vit B6、Hcy和Cys C与糖尿病肾病病变程度的相关性分析[J].检验医学与临床,2018,15(16):2371-2373.
[15]Chowdhury SR.血清胱抑素、C反应蛋白和同型半胱氨酸作为生物标志物在2型糖尿病视网膜病变中的作用[D].济南:山东大学,2016.
[16]袁娟.糖尿病周围神经病变患者血浆Hcy和Cys-C水平变化及意义[J].中国实验诊断学,2015,19(12):2119-2121.
[17]陈德鹏.血浆同型半胱氨酸和胱抑素C与糖尿病周围神经病变的相关性研究[J].中国糖尿病杂志,2014,22(12):1071-1074.
[18]Bruce SG,Young TK. Prevalence and risk factors for neuropathy in a Canadian First Nation community[J]. Diabetes Care,2008,31(9):1837-1841.
[19]Wang T,Wang Q,Wang Z,et al. Diagnostic value of the combined measurement of serum hcy,serum cys C,and urinary microalbumin in type 2 diabetes mellitus with early complicating diabetic nephropathy[J]. ISRN Endocrinol,2013,2013:407452.
[20]Zheng LQ,Zhang HL,Guan ZH,et al. Elevated serum homocysteine level in the development of diabetic peripheral neuropathy[J]. Genet Mol Res,2015,14(4):15365-15375.
[21]Leishear K,Ferrucci L,Lauretani F,et al. Vitamin B12 and homocysteine levels and 6-year change in peripheral nerve function and neurological signs[J]. J Gerontol A Biol Sci Med Sci,2012,67(5):537-543.
[22]陈福莲,陈澎,王萌. 2型糖尿病患者血浆同型半胱氨酸与神经传导异常的关系[J].中国医师进修杂志,2012,35(10):64-65,70.
[23]罗宇.血清同型半胱氨酸水平与糖尿病周围神经病变病情的相关性研究[J].中国社区医师(医学专业),2013,15(3):185.
[24]González R,Pedro T,Martinez-Hervas S,et al. Plasma homocysteine levels are independently associated with the severity of peripheral polyneuropathy in type 2 diabetic subjects[J]. J Peripher Nerv Syst,2012,17(2):191-196.
[25]彭少林,沙永红,张美彪,等.糖尿病周围神经病变患者血清C肽与同型半胱氨酸、胱抑素C的相关性研究[J].社区医学杂志,2018,16(7):57-59.
[26]董燕燕,陈光亮.高同型半胱氨酸血症危害及致病机制研究进展[J].中国药理学通报,2014,30(9):1205-1208.
[27]Marsillach J,Suzuki SM,Richter RJ,et al. Human valacyclovir hydrolase/biphenyl hydrolase-like protein is a highly efficient homocysteine thiolactonase[J]. PLo S One,2014,9(10):e110054.
[28]Sato Y,Ouchi K,Funase Y,et al. Relationship between metformin use,vitamin B12deficiency,hyperhomocysteinemia and vascular complications in patients with type 2 diabetes[J]. Endocr J,2013,60(12):1275-1280.
[29]晏丕军,张志红,徐勇,等. 2型糖尿病患者血清胱抑素C水平与振动感觉阈值的关系[J].中南大学学报(医学版),2016,41(1):58-64.
[30]Barbarash OL,Bykova IS,Kashtalap VV,et al. Serum neutrophil gelatinase-associated lipocalin has an advantage over serum cystatin C and glomerular filtration rate in prediction of adverse cardiovascular outcome in patients with ST-segment elevation myocardial infarction[J]. BMC Cardiovasc Disord,2017,17(1):81.
[31]闫萌萌,刘素筠,卓小群.胱抑素C与2型糖尿病视网膜病变的相关性研究[J].中国药物与临床,2015,5(1):128-129.
[32]Kasai H,Tsuji Y,Hiraki Y,et al. Population pharmacokinetics of teicoplanin in hospitalized elderly patients using cystatin C as an indicator of renal function[J]. J Infect Chemother,2018,24(4):284-291.
[33]Karlberg C,Falk C,Green A,et al. Proliferative retinopathy predicts nephropathy:A 25-year follow-up study of type 1 diabetic patients[J]. Acta Diabetol,2012,49(4):263-268.
[34]Chung JO,Cho DH,Chung DJ,et al. Serum Cystatin C Levels are Positively Associated with Cardiovascular Autonomic Neuropathy in Patients with Type 2 Diabetes[J]. Exp Clin Endocrinol Diabetes,2015,123(10):627-631.
[35]Ai L,Hu Y,Zhang X,et al. High cystatin C levels predict undesirable outcome for diabetic foot ulcerations[J]. Wound Repair Regen,2016,24(3):560-567.
[36]赵蔚菁,李连喜,刘风静,等.血清胱抑素C与2型糖尿病并发症的相关性研究[J].中国临床医学,2013,20(6):768-771.
[37]Hu Y,Liu F,Shen J,et al. Association between serum cystatin C and diabetic peripheral neuropathy:A cross-sectional study of a Chinese type 2 diabetic population[J]. Eur J Endocrinol,2014,171(5):641-648.
[38]罗璇,韦少恒.血清标志物与糖尿病周围神经病变的相关性[J].检验医学与临床,2017,14(14):2091-2093.
[39]陈兰英,郑芬萍,李红. 2型糖尿病周围神经病变患者血清胱抑素C水平及其临床意义[J].中国糖尿病杂志,2014,22(8):700-703.
[40]Tsai HT,Wang PH,Tee YT,et al. Imbalanced serum concentration between cathepsin B and cystatin C in patients with pelvic inflammatory disease[J]. Fertil Steril,2009,91(2):549-555.
[41]Eriksson P,Deguchi H,Samneg?rd A,et al. Human evidence that the cystatin C gene is implicated in focal progression of coronary artery disease[J]. Arterioscler Thromb Vasc Biol,2004,24(3):551-557.