FOXP1与Livin基因表达对淋巴瘤病理特征及临床预后评价价值
|
摘要
目的探讨叉头框蛋白P1(FOXP1)与Livin基因表达对淋巴瘤临床病理特征及预后的评价价值。方法选择2013-08至2015-08间在我院肿瘤科住院治疗的弥漫性大B细胞淋巴瘤患者80例为观察组,40例反应性淋巴结增生患者为对照组,观察并分析两组FOXP1与Livin表达情况。分析淋巴瘤患者FOXP1、Livin表达与临床病理特征的关系。结果观察组FOXP1及Livin高表达的比例分别为77.5%、60.0%,均显著高于对照组比例20.0%、5.0%,差异具有统计学意义(P<0.05)。淋巴瘤患者中,高中危+高危IPI、原发部位(节内)、Non-GCB者FOXP1高表达比例分别为92.3%、86.2%、86.7%,比例更高,差异具有统计学意义(P<0.05),存在B症状、高中危+高危IPI、Non-GCB者Livin高表达的比例分别为81.2%、80.8%、73.3%,比例更高,差异具有统计学意义(P<0.05)。结论弥漫性大B细胞淋巴瘤内FOXP1及Livin表达水平与其临床特征、病理类型存在密切关系。
Objective To explore the significance of FOXP1 and Livin expressions in the evaluation of clinicopathological characteristics and prognosis of lymphoma. Methods Eighty patients with diffuse large B cell lymphoma treated at our hospital between August 2013 and August 2015 were selected as observation group,with 40 cases of reactive lymph node hyperplasia patients as control group. The expressions of FOXP1 and Livin in the two groups were observed and analyzed. The relationships between the expressions of FOXP1 and Livin in patients with lymphoma and the clinicopathological features were analyzed. Results The percentage of high expressions of FOXP1 and Livin in the observation group was 77. 5% and 60% respectively,which was significantly higher than that in the control group( 20%,5%),and the difference was statistically significant( P < 0. 05). Among the high-risk IPI and non-GCB patients of lymphoma or those with primary lymphoma,high expression rates of FOXP1 were 92. 3%,86. 2%,86. 7% respectively,the proportion was higher,and the difference was statistically significant( P < 0. 05). In the presence of B-symptom,the expression rates of Livin were 81. 2%,80. 8%,73. 3% respectively,the proportion was higher,and the difference was of statistic significance( P <0. 05). Conclusions The expression level of FOXP1 and Livin in patients with diffuse large B cell lymphoma is closely related to its clinical features and pathological types.
Objective To explore the significance of FOXP1 and Livin expressions in the evaluation of clinicopathological characteristics and prognosis of lymphoma. Methods Eighty patients with diffuse large B cell lymphoma treated at our hospital between August 2013 and August 2015 were selected as observation group,with 40 cases of reactive lymph node hyperplasia patients as control group. The expressions of FOXP1 and Livin in the two groups were observed and analyzed. The relationships between the expressions of FOXP1 and Livin in patients with lymphoma and the clinicopathological features were analyzed. Results The percentage of high expressions of FOXP1 and Livin in the observation group was 77. 5% and 60% respectively,which was significantly higher than that in the control group( 20%,5%),and the difference was statistically significant( P < 0. 05). Among the high-risk IPI and non-GCB patients of lymphoma or those with primary lymphoma,high expression rates of FOXP1 were 92. 3%,86. 2%,86. 7% respectively,the proportion was higher,and the difference was statistically significant( P < 0. 05). In the presence of B-symptom,the expression rates of Livin were 81. 2%,80. 8%,73. 3% respectively,the proportion was higher,and the difference was of statistic significance( P <0. 05). Conclusions The expression level of FOXP1 and Livin in patients with diffuse large B cell lymphoma is closely related to its clinical features and pathological types.
引文
[1]陈敏,杨桂芳.弥漫大B细胞淋巴瘤两种亚型中多药耐药蛋白的表达差异及临床意义[J].武汉大学学报(医学版),2016,37(2):232-235.
[2]Chuan He,Zhigang Liu,Jie Ji,et al.Prognostic value of survivin in patients with non-Hodgkin’s lymphoma:a meta-analysis[J].Int J Clin Exp Med,2015,8(4):5847-5854.
[3]齐彦,廖斌,杨丽英,等.非霍奇金淋巴瘤中MCM2、Cx43、Skp2蛋白的表达[J].现代肿瘤医学,2016,24(6):958-961.
[4]Bo-Young Oh,Ryung-Ah Lee,Kwang Ho Kim.siRNA targeting Livin decreases tumor in a xenograft model for colon cancer[J].World J Gastroenterol,2011,17(20):2563-2571.
[5]王健超,张文燕,丁文双,等.异常表达CD56的弥漫性大B细胞淋巴瘤临床病理观察[J].中华病理学杂志,2016,10(2):78-82.
[6]范小红,孟亚红,邹健等.乙肝表面抗原阳性的非霍奇金淋巴瘤患者化疗前后T淋巴细胞亚群的变化[J].现代中西医结合杂志,2016,25(9):920-922.
[7]李贻阳,牛绍清,温戈,等.基于GELOX方案诱导化疗的Ⅰ-Ⅱ期结外鼻型K/T细胞淋巴瘤根治性放疗的预后分析[J].中华放射肿瘤学杂志,2016,25(2):140-145.
[8]张亚楠.FOXP1蛋白在弥漫性大B细胞淋巴瘤中的表达及预后意义[J].重庆医学,2015,44(17):2368-2370.
[9]朱丹,王瑛坚.原发性卵巢上皮性恶性肿瘤中Livin和Fas的表达及相关性分析[J].中国实验诊断学,2014,18(8):1312-1314.
[10]陈廷玉,卢春凤,关宝生,等.宫颈癌中Livin和COX-2蛋白的表达及相关性研究[J].解剖学研究,2015,37(5):398-400.
[11]胡成如,王靖华,耿怀成,等.叉头框转录蛋白1在弥漫性大B细胞淋巴瘤中的表达及预后意义[J].临床肿瘤学杂志,2012,17(4):339-342.
[12]沈琳,陈波斌,陈字,等.原发性中枢神经系统淋巴瘤FOXPl和Cyclin E的表达及其意义[J].中华血液学杂志,2012,33(8):648-652.
[13]I Abd-Elrahman,V Deutsch,M Pick,et al.Differential regulation of the apoptotic machinery during megakaryocyte differentiation and platelet production by inhibitor of apoptosis protein Livin[J].Cell Death Dis,2013,4(11):e937.
[14]李蓉,潘湘涛,陆晔,等.Livin和Smac蛋白在非霍奇金淋巴瘤中的表达及其临床意义[J].白血病.淋巴瘤,2010,11(8):494-496.
[15]李文琦,李晓林.Livin和Survivin基因在成人急性淋巴细胞白血病中的表达及临床意义[J].中国实验血液学杂志,2011,19(4):921-925.
[2]Chuan He,Zhigang Liu,Jie Ji,et al.Prognostic value of survivin in patients with non-Hodgkin’s lymphoma:a meta-analysis[J].Int J Clin Exp Med,2015,8(4):5847-5854.
[3]齐彦,廖斌,杨丽英,等.非霍奇金淋巴瘤中MCM2、Cx43、Skp2蛋白的表达[J].现代肿瘤医学,2016,24(6):958-961.
[4]Bo-Young Oh,Ryung-Ah Lee,Kwang Ho Kim.siRNA targeting Livin decreases tumor in a xenograft model for colon cancer[J].World J Gastroenterol,2011,17(20):2563-2571.
[5]王健超,张文燕,丁文双,等.异常表达CD56的弥漫性大B细胞淋巴瘤临床病理观察[J].中华病理学杂志,2016,10(2):78-82.
[6]范小红,孟亚红,邹健等.乙肝表面抗原阳性的非霍奇金淋巴瘤患者化疗前后T淋巴细胞亚群的变化[J].现代中西医结合杂志,2016,25(9):920-922.
[7]李贻阳,牛绍清,温戈,等.基于GELOX方案诱导化疗的Ⅰ-Ⅱ期结外鼻型K/T细胞淋巴瘤根治性放疗的预后分析[J].中华放射肿瘤学杂志,2016,25(2):140-145.
[8]张亚楠.FOXP1蛋白在弥漫性大B细胞淋巴瘤中的表达及预后意义[J].重庆医学,2015,44(17):2368-2370.
[9]朱丹,王瑛坚.原发性卵巢上皮性恶性肿瘤中Livin和Fas的表达及相关性分析[J].中国实验诊断学,2014,18(8):1312-1314.
[10]陈廷玉,卢春凤,关宝生,等.宫颈癌中Livin和COX-2蛋白的表达及相关性研究[J].解剖学研究,2015,37(5):398-400.
[11]胡成如,王靖华,耿怀成,等.叉头框转录蛋白1在弥漫性大B细胞淋巴瘤中的表达及预后意义[J].临床肿瘤学杂志,2012,17(4):339-342.
[12]沈琳,陈波斌,陈字,等.原发性中枢神经系统淋巴瘤FOXPl和Cyclin E的表达及其意义[J].中华血液学杂志,2012,33(8):648-652.
[13]I Abd-Elrahman,V Deutsch,M Pick,et al.Differential regulation of the apoptotic machinery during megakaryocyte differentiation and platelet production by inhibitor of apoptosis protein Livin[J].Cell Death Dis,2013,4(11):e937.
[14]李蓉,潘湘涛,陆晔,等.Livin和Smac蛋白在非霍奇金淋巴瘤中的表达及其临床意义[J].白血病.淋巴瘤,2010,11(8):494-496.
[15]李文琦,李晓林.Livin和Survivin基因在成人急性淋巴细胞白血病中的表达及临床意义[J].中国实验血液学杂志,2011,19(4):921-925.